BODY CELL MASS DURING LONG-TERM TREATMENT WITH CORTISONE AND ANABOLIC STEROIDS IN ASTHMATIC SUBJECTS

1967 ◽  
Vol 55 (2) ◽  
pp. 222-239 ◽  
Author(s):  
Björn Lindholm

ABSTRACT Thirty-six patients (17 males and 19 females) with severe bronchial asthma were treated for more than two years with cortisone and norandrolone. The patients were followed by repeated estimations of the body cell mass (BCM) using total exchangeable potassium (Ke) as a parameter of cell mass. In ten of the female patients, determinations of total body water (TBW) were also performed at the end of anabolic treatment. BCM increased significantly in both male (3.3 kg) and female (4.5 kg) patients. The relative increase in BCM was more pronounced in the female (25%) than in the male patients (13%). After one year of anabolic therapy, no further increase in BCM was demonstrated in either sex. The male patients did not increase more than was seen in male patients on cortisone only and previously reported. The average body weight was unchanged during the study, indicating a decrease in body fat. In the female patients, the final relative body cell mass was higher than in normal women and similar to that of normal men. TBW also increased in proportion to Ke and at the end of treatment the quotient TBW/B.W. was not different from that of normal men. The regression of Ke on TBW was normal. The significance of these findings are discussed. During treatment, one woman developed radiological signs of osteoporosis and two males showed progression of bone atrophy, which was diagnosed before the study.

2000 ◽  
pp. 18-32 ◽  
Author(s):  
Richard N. Pierson ◽  
Jack Wang
Keyword(s):  
The Body ◽  

1963 ◽  
Vol 43 (9) ◽  
pp. 695-695
Author(s):  
H. D. Bouman
Keyword(s):  
The Body ◽  

Author(s):  
Marilia Firmino De Castro Ribeiro ◽  
Juliana Megumi Nisio dos Reis ◽  
Ana Paula Bazanelli

Os parâmetros não tradicionais derivados da bioimpedância elétrica (BIA) como reatância, ângulo de fase e massa celular estão cada vez sendo mais utilizados na prática clínica para auxiliar no diagnóstico nutricional dos pacientes com doença renal crônica e, consequentemente, no prognóstico clínico dessa população. O presente estudo teve por objetivo avaliar a relação dos parâmetros derivados da BIA com o estado nutricional de pacientes em hemodiálise. Estudo transversal, realizado com trinta pacientes adultos de uma clínica de Nefrologia localizada na região metropolitana de São Paulo. Foi utilizada a BIA para avaliar esses parâmetros, assim como para avaliar a composição corporal. A amostra foi constituída por homens e mulheres com média de idade de aproximadamente 56 anos. O ângulo de fase dos pacientes foi de 5,9±1,6 graus e apresentou uma correlação negativa com idade (r= -0,69, p< 0,001) e água corporal extracelular (r= -0,93 p< 0,001). A média de reatância foi de 50,9±16,08 ohms e apresentou correlação negativa com a água extracelular (r= -0,82, p<0,001) e positiva com a massa celular (r=0,51, p<0,004). Em relação ao percentual de massa celular, a média foi de 36,8± 6,1%, sendo que a mesma apresentou uma correlação negativa com a idade (r= -0,66, p< 0,001), gordura corporal (r= -0,73, p< 0,001), água corporal extracelular (r= -0,82, p<0,001).Conclui-se que os parâmetros não tradicionais derivados da BIA apresentaram boa associação com o estado nutricional dos pacientes, podendo dessa forma, serem aliados importantes para obtenção do melhor diagnóstico nutricional e, consequentemente, do prognóstico dos mesmos durante o tratamento dialítico.Palavras-chave: Bioimpedância Elétrica. Estado Nutricional. Diálise.AbstractNon-traditional parameters derived from bioelectrical impedance analysis (BIA) as reactance, phase angle and cell mass are increasingly being used in clinical practice to improve the nutritionalstatus of chronic kidney disease patients andthe clinical outcomes in this population. The present study aimed to evaluate the relationship of parameters derived from the BIA with nutritional status of hemodialysis patients. It was a cross-sectional study with 30 adultspatients of a nephrology clinic in the metropolitan region of São Paulo. BIA was used to evaluate as well as to assess the body composition. The mean age of the patients was approximately 56 years. The phase angle of the patients was 5.9 ± 1.6 degrees and it was negatively correlated with age (r = -0.69, p <0.001) andwith extracellular body water (r = -0.93 p <0.001). The mean reactance was 50.9 ± 16.08 ohms and it showed a negative correlation with the extracellular water (r = -0.82, p <0.001) and positively with the body cell mass (r = 0.51, p <0.004). Regarding to the percentage of body cell mass, the mean was 36.8 ± 6.1%, and it presented a negative correlation with age (r = -0.66, p <0.001), body fat (r = -0.73, p <0.001) and with body water extracellular (r = -0.82, p <0.001). The present study concluded that non-traditional parameters derived from BIA showed a good association with the nutritional status of hemodialysis patients. It is important for getting the best nutritional diagnosis and consequently the prognosis of these patientsduring the dialysis treatment.Keywords: Bioelectrical Impedance. Nutritional Status. Dialysis.


1974 ◽  
Vol 20 (9) ◽  
pp. 1155-1158 ◽  
Author(s):  
James March ◽  
William J Turner ◽  
Josette Shanley ◽  
John Field

Abstract The urinary excretion of D-glucaric acid reflects the activity of hepatic enzymes that hydroxylate and detoxify many substances foreign to the body. We measured it in 38 healthy unmedicated males (ages, 3 to 90 years; weights 11.8 to 136 kg) and in 15 females (ages, 10 to 80). The males, regardless of age or weight, excreted 56.1 ± 15.7 (SD) nmol of D-glucaric acid per milligram of creatinine. A "standard man" would excrete 98 µmol of this compound per day, in agreement with observations by other workers. We infer that the normal hydroxylating activity of the liver is a direct function of body cell mass.


1967 ◽  
Vol 55 (2) ◽  
pp. 202-221 ◽  
Author(s):  
Björn Lindholm

ABSTRACT The body cell mass (BCM) was estimated from determinations of the total exchangeable potassium (Ke) in 66 patients with severe bronchial asthma requiring long-term treatment with daily doses of glucocorticoids equivalent to 25–75 mg of cortisone. Thirty subjects had been treated with cortisone for more than six years (2–12 years) prior to the present study. The remaining thirty-six patients were studied at the beginning of the cortisone treatment period. Twenty-two patients from both groups were followed during more than two years of daily cortisone therapy by repeated, paired Ke-determinations. Ke was determined by the isotope dilution technique. In all, 297 such determinations were performed by oral administration of 42K, allowing the isotope to equilibrate for 45 hours. The initial body content of Ke in male and female subjects with or without several years of previous cortisone therapy did not differ from normal subjects, when related to body weight and age. A statistical analysis revealed a significant increase in the total exchangeable potassium of both male and female subjects during treatment with cortisone. None of the patients showed significantly decreasing Ke-values during the longitudinal study. Body weight showed a covariation with Ke but did not, on an average, increase significantly with time. Cortisone induced osteoporosis was found in twelve subjects. Taken as a group, these subjects showed normal values of Ke, when related to body weight and age. Apparently, bone atrophy can develop during cortisone treatment without concomitant atrophy of the BCM.


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