EFFECT OF TESTOSTERONE ON 3H-LABELLING OF THE RNA AND PROTEINS IN THE PROSTATE AND SEMINAL VESICLES OF IMMATURE RATS AFTER ADMINISTRATION OF 3H-URIDINE
6-Methylene-4-pregnene-3,20-dione, a potent irreversible inhibitor of rat prostate 5α-reductase in vitro, markedly inhibited the growth of the ventral prostate and seminal vesicles in immature rats when administered s.c. in a daily dose of 100 mg/kg body weight for 35 days. Kidney and testes weights were reduced, together with some reduction in body weight. In the mature rat treated with this steroid in a dose of 40 mg/kg body weight per day for 11 days, marked regression in ventral prostate and seminal vesicles was observed.
It is well known that epithelial hyperplasia (benign hypertrophy) is common in the aging prostate of dogs and man. In contrast, little evidence is available for abnormal epithelial cell growth in seminal vesicles of aging animals. Recently, enlarged seminal vesicles were reported in senescent mice, however, that enlargement resulted from increased storage of secretion in the lumen and occurred concomitant to epithelial hypoplasia in that species.The present study is concerned with electron microscopic observations of changes occurring in the pseudostratified epithelium of the seminal vescles of aging rats. Special attention is given to certain non-epithelial cells which have entered the epithelial layer.
ABSTRACT
The succinic, malic and isocitric dehydrogenases in the ovary of immature and mature, normal and serum gonadotrophin injected rats were examined. The Qo2 of these enzymes were markedly enhanced in the gonadotrophin injected rats of both age groups, except in the case of succinic dehydrogenase in the ovary of the immature rats, where a slight non-significant decrease was noted.
It is concluded that in the mature rat ovary, gonadotrophin administration stimulates the activity of all the examined dehydrogenases of the citric acid cycle, whereas in the immature rat ovary, at least the isocitric- and malic dehydrogenases are thus stimulated.
ABSTRACT
The uptake of intravenously administered tritiated oestradiol by the uterus and pituitary gland of untreated, as well as clomiphene pretreated immature rats was studied to elucidate the nature of the antioestrogenic action of clomiphene. The results indicate that this agent competes with the natural oestrogen for the receptor sites in the uterus and pituitary gland and prevents the entry of oestrogen to and probably displaces it from the receptor sites. The significance of these observations with respect to the ability of clomiphene for the induction of ovulation in anovulatory women is discussed.
ONE-FACTOR DISPERSING ANALYSIS OF SEMINAL VESICLES OF IMMATURE RATS OBTAINED UNDER CONDITIONS OF HYPERTHERMIA AND CORRECTOR APPLICATION EFFECT
