Investigation of urinary neutral steroid profiles as a diagnostic tool in Cushing's syndrome and adrenocortical tumors

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S61-S62
Author(s):  
J. HOMOKI ◽  
W. R. HOLL
Keyword(s):  
Cushing’S Syndrome ◽  
Diagnostic Tool ◽  
Cushing's Syndrome ◽  
Adrenocortical Tumors ◽  
Neutral Steroid ◽  
Steroid Profiles

The diagnostical importance of steroid profiles of biological fluids of patients with Cushing’s syndrome

2015 ◽  
Vol 61 (4) ◽  
pp. 4-8 ◽  
Author(s):  
Z R Shafigullina ◽  
L I Velikanova ◽  
N V Vorohobina ◽  
A A Lisicyn ◽  
E A Kuhianidze ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Steroid Hormones ◽  
Diagnostic Criteria ◽  
Cushing’S Syndrome ◽  
Biological Fluids ◽  
Cushing's Syndrome ◽  
Gas Chromatography Mass Spectrometry ◽  
Adrenocortical Adenoma ◽  
Steroid Profiles

Steroid profiles of 49 patients having Cushing’s syndrome were investigated. Differential diagnostic criteria of Cushing’s syndrome with adrenocortical adenoma and adrenocarcinoma and features of steroid hormones metabolism were established by combination of classical tests and steroid profiles investigation using HPLC and gas chromatography - mass-spectrometry. The adrenocarcinoma was diagnosed for 22,4% of patients having Cushing’s syndrome and the main biochemical criteria were the increasing of 11-deoxycortisol in blood (>20 ng/ml), the excretion of 18-OH-corticosterone and metabolites of glucocorticoids and pregnenes, 8,2% of patients having Cushing’s syndrome had additionally increased androgens metabolites excretion.

Cushing's syndrome induced by hypersecretion of cortisol from only one of bilateral adrenocortical tumors

Metabolism ◽  
1992 ◽  
Vol 41 (3) ◽  
pp. 260-263 ◽  
Author(s):  
Sumio Kato ◽  
Rumi Masunaga ◽  
Tetsuya Kawabe ◽  
Akio Nagasaka ◽  
Takako Miyamoto ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Adrenocortical Tumors

ALDOSTERON, CORTISOL UND CORTISON IM HARN UND IN OPERATIV ENTFERNTEN NEBENNIEREN BEI PATIENTEN MIT CUSHING-SYNDROM

1962 ◽  
Vol 41 (4) ◽  
pp. 531-545 ◽  
Author(s):  
F. H. Franken ◽  
H. Zimmermann
Keyword(s):  
Cushing’S Syndrome ◽  
Normal Level ◽  
Diagnostic Tool ◽  
Normal Limit ◽  
Cushing's Syndrome ◽  
Upper Limit ◽  
Valuable Diagnostic Tool ◽  
Adrenocortical Hyperplasia ◽  
Cortisol Excretion

ABSTRACT Few studies on the excretion of cortisol and cortisone in urine with simultaneous estimations of aldosterone have been performed in cases of Cushing's Syndrome. Using the methods of Neher & Wettstein (1956) for the determination of cortisol, cortisone and aldosterone, studies were made on 8 patients with Cushing's Syndrome and adrenocortical hyperplasia. The excretion of aldosterone was normal in 5 cases and increased in 3 cases. The increase in excretion of cortisol was much greater than that of cortisone, while the excretion of 17-OHCS though frequently increased, was not very large. In 5 cases cortisol, cortisone, aldosterone and the 17-OHCS were determined in urine after the administration of ACTH. In these experiments the excretion of cortisol and cortisone was much higher than that of 17-OHCS. In one case, the amount of cortisol was found to be almost 200 times the upper normal limit. The excretion of aldosterone was slightly elevated in one case but showed considerable increases in 2 cases. 2 patients were given SU 4885 for several days. After this treatment the excretion of aldosterone was considerably decreased (<0.5 μg), cortisol and cortisone could, however, still be measured in small quantities. One of the 2 patients showed a new increase of cortisol excretion amounting to 10 times the upper limit during the fourth day of administration of SU 4885. A considerable elevation of 17-OHCS in the urine was also found. One of the patients was given dexamethasone, which brought about a decrease in cortisol, cortisone and 17-OHCS in the urine, the aldosterone content remaining at a normal level. In addition cortisol, cortisone, corticosterone and aldosterone were determined by the method of Neher (1958), in the adrenals of 6 patients following operation. Taking the few corresponding studies on normal adrenals as a standard our results expressed in percentage showed an increased cortisol content. According to our experiments the estimation of cortisol in urine is a more valuable diagnostic tool in Cushing's Syndrome than that of 17-OHCS. Furthermore the excretion of both cortisol and aldosterone is not constant. The production of both hormones can be stimulated by ACTH.

ACTH-Independent Cushing’s Syndrome: Adrenocortical Tumors

2010 ◽  
pp. 189-208
Author(s):  
Maria Candida Barisson Villares Fragoso ◽  
Sorahia Domenice ◽  
Ana Claudia Latronico ◽  
Berenice Bilharinho Mendonca
Keyword(s):  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Adrenocortical Tumors

Cushing's Syndrome in an Infant Secondary to Malignant Adrenocortical Tumors with Somatic Mutation of Beta-Catenin

2010 ◽  
Vol 13 (3) ◽  
pp. 238-242 ◽  
Author(s):  
Theerawut Pusantisampan ◽  
Surasak Sangkhathat ◽  
Kanita Kayasut ◽  
Samornmas Kanngurn ◽  
Somchit Jaruratanasirikul ◽  
...  
Keyword(s):  
Somatic Mutation ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Beta Catenin ◽  
Adrenocortical Tumors

scholarly journals SAT-162 Potential Diagnostic Use of a Steroid Profile in Patients with Poorly Controlled Diabetes Mellitus

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Kellie Fecteau ◽  
Luca Giori ◽  
Alex Esteller-Vico ◽  
Hugo Eiler
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Insulin Secretion ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Laboratory Evaluation ◽  
Beta Cell Proliferation ◽  
Steroid Profile ◽  
Steroid Profiles ◽  
17 Hydroxyprogesterone

Abstract Cushing’s syndrome may contribute to insulin resistance and impaired insulin secretion in patients with diabetes mellitus. The prevalence of Cushing’s syndrome in human patients with type II diabetes mellitus has been reported as high as 9.4% (1), and prevalence of diabetes mellitus as a complication of Cushing’s syndrome has been reported as high as 50% (2). In our laboratory, evaluation of steroid profiles (analysis of cortisol, progesterone, 17-hydroxyprogesterone, androstenedione, estradiol, testosterone, and aldosterone at baseline and post-ACTH) in 3,600 dogs over 2 years revealed 2% to 8% of dogs with diabetes mellitus had concurrent hyperadrenocorticism. These steroid profiles in dogs with uncontrolled diabetes mellitus, despite insulin therapy, implicated elevated estradiol, progesterone, and 17-hydroxyprogesterone concentrations, with or without elevated cortisol, as probable contributors to poor control of glycemia. It has been reported that high doses of estradiol can decrease expression of insulin receptors in target tissues (3) and progesterone can decrease GLUT 4 expression in target tissues and modulate beta cell proliferation in the pancreas (4), thereby contributing to insulin resistance and possibly insulin secretion. In human patients, decreasing cortisol concentration in Cushing’s syndrome improves the glycemic state in many, but not all gain normoglycemia (5). It is suspected, that for some human patients, cortisol is not the only steroid involved in hyperglycemia and a steroid profile may be a useful diagnostic tool for investigating other steroids contributing to insulin resistance. References: (1) Nieman, Endocrinol Metab Clin N Am. 2018; 47:259-273. (2) Giordano et al., Eur J Endocrinol. 2014; 170:311-319. (3) Gonzalez et al., Steroids. 2002; 67:993-1005. (4) Branisteanu et al., TRENDS Endocrinol Metab. 2003; 14:54-56. (5) Rogowicz-Frontczak et al., Endokrynol Pol. 2017; 68:334-342.

CUSHING'S SYNDROME DUE TO ADRENOCORTICAL CARCINOMA A COMPHRENSIVE CLINICAL AND BIOCHEMICAL STUDY OF PATIENTS TREATED BY SURGERY AND CHEMOTHERAPY

1979 ◽  
Vol 91 (2) ◽  
pp. 303-318 ◽  
Author(s):  
W. F. Kelly ◽  
A. J. Barnes ◽  
J. Cassar ◽  
M. White ◽  
K. Mashiter ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Biochemical Study ◽  
Serum Testosterone ◽  
Cushing's Syndrome ◽  
Surgical Removal ◽  
Steroid Profiles ◽  
New Finding ◽  
The Mean ◽  
Biochemical Remission ◽  
Short Time

ABSTRACT Four post-mencpausal women had Cushing's syndrome due to adrenal cortical carcinomas. Comprehensive analyses of blood and urinary steroids showed that although the steroid profiles differed between patients, the pattern in each patient remained almost constant as the disease progressed, or remitted due to therapy. Elevations of serum testosterone and oestradiol were commensurate with the extent of virilisation, and the urinary output of aldosterone was associated with the severity of hypertension. A new finding was that all had substantially increased urinary free deoxycorticosterone. Complete surgical removal of the primary tumours was impossible but when most of the tumour tissue was removed, full clinical and biochemical remissions were obtained for a short time in 2 patients. One patient obtained a clinical and biochemical remission from op'DDD. In another patient the drug caused reduction both in blood pressure and in urinary aldosterone excretion, but there were unpleasant side effects. A third patient could not tolerate op'DDD. Metyrapone therapy produced neither clinical nor biochemical improvement in 3 patients. The mean duration of survival was 17 months after the first symptoms and 10 months from the date of operation. Despite advances in drug therapy, adrenal cortical carcinoma remains a lethal disease. Biochemical screening of multiple steroids offers a means of early diagnosis and disease monitoring. Extensive surgical removal of the tumour offers the best chance of a clinical and biochemical remission.

Sign in / Sign up

Export Citation Format

Share Document