scholarly journals The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis

2013 ◽  
Vol 168 (3) ◽  
pp. 343-349 ◽  
Author(s):  
Ju-Han Lee ◽  
Younghye Kim ◽  
Jung-Woo Choi ◽  
Young-Sik Kim
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Hashimoto’S Thyroiditis ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Effect Sizes ◽  
Hashimoto's Thyroiditis ◽  
Papillary Thyroid ◽  
Clinicopathologic Characteristics ◽  
Clinicopathologic Parameters

ObjectiveNo consensus exists on the association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT). To resolve this controversy, this study aimed to evaluate the relationship between the two conditions using a meta-analysis.MethodsWe searched relevant published studies using citation databases including PubMed, Embase, and ISI Web of Science. The effect sizes of clinicopathologic parameters were calculated by odds ratio (OR), weighted mean difference, or hazard ratio (HR). The effect sizes were combined using a random-effects model.ResultsThirty-eight eligible studies including 10 648 PTC cases were selected. Histologically proven HT was identified in 2471 (23.2%) PTCs. HT was more frequently observed in PTCs than in benign thyroid diseases and other carcinomas (OR=2.8 and 2.4;P<0.001). PTCs with coexisting HT were significantly related to female patients (OR=2.7;P<0.001), multifocal involvement (OR=1.5;P=0.010), no extrathyroidal extension (OR=1.3;P=0.002), and no lymph node metastasis (OR=1.3;P=0.041). Moreover, PTCs with HT were significantly associated with long recurrence-free survival (HR=0.6;P=0.001).ConclusionsOur meta-analysis showed that PTC is significantly associated with pathologically confirmed HT. PTC patients with HT have favorable clinicopathologic characteristics compared with PTCs without HT. However, patients with HT need to be carefully monitored for the development of PTC.

scholarly journals A meta-analysis of Hashimoto’s thyroiditis and papillary thyroid carcinoma risk

Oncotarget ◽  
2017 ◽  
Vol 8 (37) ◽  
pp. 62414-62424 ◽  
Author(s):  
Xingjian Lai ◽  
Yu Xia ◽  
Bo Zhang ◽  
Jianchu Li ◽  
Yuxin Jiang
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Hashimoto’S Thyroiditis ◽  
Meta Analysis ◽  
Hashimoto's Thyroiditis ◽  
Papillary Thyroid ◽  
Carcinoma Risk

scholarly journals The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Min-kyung Yeo ◽  
Ja Seong Bae ◽  
Sohee Lee ◽  
Min-Hee Kim ◽  
Dong-Jun Lim ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Hashimoto’S Thyroiditis ◽  
Extrathyroidal Extension ◽  
Hashimoto's Thyroiditis ◽  
Molecular Characteristics ◽  
Papillary Thyroid ◽  
Clinicopathologic Characteristics ◽  
Node Metastasis ◽  
Molecular Features

Background. The Warthin-like variant of papillary thyroid (WLPTC) is a rare subtype of papillary thyroid carcinoma (PTC) resembling Warthin tumors of the salivary glands. Due to its rarity, the clinicopathologic and molecular features of WLPTC remain unclear.Methods. Of the 2,139 patients who underwent surgical treatment for PTC from 2012 to 2013, 40 patients with WLPTC were identified and compared to 200 consecutive patients with classic PTC.BRAFmutation was tested with pyrosequencing.Results. There were no significant differences in age, predilection for women, multifocality, extrathyroidal extension, or lymph node metastasis between WLPTC and classic PTC. However, WLPTCs were more commonly associated with Hashimoto’s thyroiditis than classic PTCs (93% versus 36%, resp.,P< 0.001) and showed significantly lower rate ofBRAFmutation when compared to classic PTCs (65% versus 84%, resp.,P= 0.007). In classic PTC, the frequency ofBRAFmutations was negatively correlated with coexisting Hashimoto’s thyroiditis. When we compared WLPTC and classic PTC in the patients with coexisting Hashimoto’s thyroiditis, there were no significant differences in clinicopathologic characteristics or theBRAFmutational rate between the two groups.Conclusions. Patients with WLPTC have similar demographic, clinical, pathologic, and molecular characteristics to those with classic PTC coexisting with Hashimoto’s thyroiditis.

scholarly journals Papillary Thyroid Carcinoma Arising in Children and Adolescent Hashimoto’s Thyroiditis: Ultrasonographic and Pathologic Findings

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Sun Hye Jeong ◽  
Hyun Sook Hong ◽  
Eun Hye Lee ◽  
Jeong Ja Kwak
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Gland ◽  
Thyroid Carcinoma ◽  
Lymph Node Metastases ◽  
Hashimoto’S Thyroiditis ◽  
Extrathyroidal Extension ◽  
Hashimoto's Thyroiditis ◽  
Papillary Thyroid ◽  
Node Metastases

Objectives. We compared the ultrasonography and pathology features of papillary thyroid carcinoma (PTC) in pediatric and adolescents with Hashimoto’s thyroiditis (HT) with those of non-HT patients.Materials and Methods. Eleven patients who were surgically confirmed to have pediatric or adolescent PTC from 2006 to 2014 were included in this study. We retrospectively analyzed the preoperative ultrasonography and pathology features of PTC arising in HT and non-HT patients.Results. On ultrasonography, thyroid gland was lobulated and enlarged, with many scattered microcalcifications in four of five HT patients. Four of six non-HT patients had suspicious masses with calcifications. The diffuse sclerosing variant of PTC (DSVPTC) was found in three of five HT patients, but none in non-HT patients. Macroscopic or microscopic extrathyroidal extension was evident in all of the HT patients and four of the non-HT patients. Neck lymph node metastases were in all HT patients and five of non-HT patients.Conclusions. Three of five PTCs in pediatric and adolescent HT patients were DSVPTC, whereas all PTCs of the non-HT patients were classic type. On ultrasonography, thyroid gland was diffusely enlarged with scattered microcalcifications in four of five HT patients. All five HT cases had aggressive disease, including extrathyroidal extension and cervical lymph node metastases.

scholarly journals Report of a case of papillary thyroid carcinoma in association with Hashimoto's thyroiditis

2015 ◽  
Vol 56 (6) ◽  
pp. 433 ◽  
Author(s):  
ChukwudiOnyeaghana Okani ◽  
Benjamin Otene ◽  
Terhemba Nyaga ◽  
Joseph Ngbea ◽  
Agaba Eke ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Papillary Thyroid
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