The -857C/T single-nucleotide polymorphism of TNF[alpha] gene is associated with bone mineral density in Greek peri- and postmenopausal women

2014 ◽  
Author(s):  
Anastasia Markatseli ◽  
Leandros Lazaros ◽  
Sofia Markoula ◽  
Stelios Tigas ◽  
Ioannis Georgiou ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Single Nucleotide Polymorphism ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Tnf Alpha ◽  
Nucleotide Polymorphism ◽  
Mineral Density ◽  
Single Nucleotide ◽  
Alpha Gene

Association of a single nucleotide polymorphism in the secreted frizzled-related protein 4 (sFRP4) gene with bone mineral density

2004 ◽  
Vol 4 (3) ◽  
pp. 175-180 ◽  
Author(s):  
Masayo Fujita ◽  
Tomohiko Urano ◽  
Masataka Shiraki ◽  
Mikio Momoeda ◽  
Osamu Tsutsumi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Single Nucleotide Polymorphism ◽  
Bone Mineral ◽  
Related Protein ◽  
Nucleotide Polymorphism ◽  
Mineral Density ◽  
Single Nucleotide

Association of a single nucleotide polymorphism in Wnt10bgene with bone mineral density

2007 ◽  
Vol 7 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Takahiko Usui ◽  
Tomohiko Urano ◽  
Masataka Shiraki ◽  
Yasuyoshi Ouchi ◽  
Satoshi Inoue
Keyword(s):  
Bone Mineral Density ◽  
Single Nucleotide Polymorphism ◽  
Bone Mineral ◽  
Nucleotide Polymorphism ◽  
Mineral Density ◽  
Single Nucleotide

scholarly journals Relationship Between GIP Receptor Gene Polymorphism rs10423928 and Bone Mineral Density in Postmenopausal Women in Shanghai

2020 ◽  
Author(s):  
Lizhi Zhang ◽  
Jinwei He ◽  
Xiang Sun ◽  
Dongyue Pang ◽  
Jingjing Hu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Receptor Gene ◽  
Nucleotide Polymorphism ◽  
Mineral Density ◽  
Single Nucleotide ◽  
Receptor Gene Polymorphism ◽  
Insulinotropic Peptide ◽  
The Relationship

Abstract Background: GIP (glucose-dependent insulinotropic peptide) has been found to affect bone metabolism. GIPR single nucleotide polymorphism (SNP) is related to its activity, but the relationship between GIPR SNP and osteoporosis in postmenopausal women is still unclear. The Aim of this study was to investigate the association between GIPR SNP and bone mineral density (BMD) in postmenopausal women in Shanghai.Methods: GIP SNP rs10423928 was detected in 884 postmenopausal women in Shanghai. The correlation between GIPR SNP and BMD was further assessed.Results: There was a statistical difference between the dominant model of this site rs10423928 and the bone mineral density of the femoral neck (P = 0.035) and the Wards triangle area (P = 0.033). Conclusions: The rs10423928 of GIPR is related to the BMD of postmenopausal women in Shanghai, China.

Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5?-flanking region (?5229G/A) with bone mineral density

2005 ◽  
Vol 23 (3) ◽  
pp. 226-230 ◽  
Author(s):  
Tomohiko Urano ◽  
Masataka Shiraki ◽  
Masayo Fujita ◽  
Takayuki Hosoi ◽  
Hajime Orimo ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Single Nucleotide Polymorphism ◽  
Bone Mineral ◽  
Nucleotide Polymorphism ◽  
Mineral Density ◽  
Single Nucleotide ◽  
Flanking Region

scholarly journals TNF-alpha gene polymorphism and plasma TNF-alpha levels are related to lumbar spine bone area in healthy female Caucasian adolescents

2002 ◽  
pp. 629-634 ◽  
Author(s):  
P Wennberg ◽  
P Nordstrom ◽  
R Lorentzon ◽  
UH Lerner ◽  
M Lorentzon
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Adolescent Girls ◽  
Tnf Alpha ◽  
Bone Area ◽  
Mineral Density ◽  
Allelic Variants ◽  
Alpha Gene

OBJECTIVE: The cytokine tumor necrosis factor alpha (TNF-alpha) is an important regulator of bone metabolism. Polymorphisms in the promoter region of the TNF-alpha gene at positions -308 and -863 have been identified. We investigated whether these polymorphisms and circulating TNF-alpha levels were related to bone mineral density and bone area in adolescent girls. DESIGN: Bone mineral density (BMD), bone area (BA), anthropometric characteristics and biochemical analyses were measured in adolescent girls and compared with regard to TNF-alpha genotype. METHODS: Allelic variants of the TNF-alpha gene in 97 girls, aged 16.9+/-1.2 years (mean+/-S.D.), were identified using polymerase chain reaction and the restriction endonucleases NcoI and TaiI. Bone mineral density and bone area of the femoral neck, lumbar spine and total body were measured using dual energy X-ray absorptiometry. RESULTS: Carriers of the rare -863 A allele (n=25) had higher body weight (P=0.03), lumbar spine BMD (P=0.02), and larger total BA (P=0.03), femoral neck area (P<0.05), and lumbar spine area (P=0.01). The independent predictors of BMD and BA were investigated using multiple regression. The TNF-alpha-863 genotypes (beta=0.18, P=0.03) and the TNF-alpha plasma levels (beta=0.19, P=0.04) independently predicted BA of the lumbar spine but not BA or BMD of any other measured sites. No statistically significant differences in body constitution parameters, biochemical parameters, bone density, or bone area at the measured skeletal sites were found when comparing the groups defined by the allelic variants at position -308 (P=0.17-0.84). CONCLUSIONS: We found the TNF-alpha-863 polymorphism and the TNF-alpha plasma levels to be independent predictors of lumbar spine area in healthy Caucasian adolescent females.

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