A novel modulator of cellular invasion and metastasis in endocrine cancer

2015 ◽  
Author(s):  
Rachel Watkins ◽  
Waraporn Imruetaicharoenchoke ◽  
Neil Sharma ◽  
Erica Gentillin ◽  
Emy Bosseboeuf ◽  
...  
Keyword(s):  
Invasion And Metastasis ◽  
Cellular Invasion

MicroRNA-183 functions as the tumor suppressor via inhibiting cellular invasion and metastasis by targeting MMP-9 in cervical cancer

2016 ◽  
Vol 141 (1) ◽  
pp. 166-174 ◽  
Author(s):  
Dongmei Fan ◽  
Ying Wang ◽  
Pengwei Qi ◽  
Yawei Chen ◽  
Po Xu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Invasion And Metastasis ◽  
Cellular Invasion

GPER‐regulated lncRNA‐Glu promotes glutamate secretion to enhance cellular invasion and metastasis in triple‐negative breast cancer

2020 ◽  
Vol 34 (3) ◽  
pp. 4557-4572 ◽  
Author(s):  
Jiali Yin ◽  
Gang Tu ◽  
Meixi Peng ◽  
Huan Zeng ◽  
Xueying Wan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Invasion And Metastasis ◽  
Cellular Invasion

26. A novel modulator of cellular invasion and metastasis

2015 ◽  
Vol 41 (10) ◽  
pp. S87
Author(s):  
N. Sharma ◽  
W. Imruetaicharoenchoke ◽  
R.J. Watkins ◽  
E. Gentillin ◽  
E. Bosseboeuf ◽  
...  
Keyword(s):  
Invasion And Metastasis ◽  
Cellular Invasion

Metalloproteinase domain structure, cellular invasion and metastasis

1994 ◽  
Vol 22 (1) ◽  
pp. 55-57 ◽  
Author(s):  
Mark I. Cockett ◽  
Mary L. Birch ◽  
Gillian Murphy ◽  
Ian R. Hart ◽  
Andrew J. P. Docherty
Keyword(s):  
Domain Structure ◽  
Invasion And Metastasis ◽  
Cellular Invasion

Morphological Characteristics of the Stroma in Malignat Epithelial Neoplasms with Short Review of Skin Squamous Cell Carcinoma

2014 ◽  
Vol 68 (1) ◽  
pp. 8-15
Author(s):  
Lena Kakasheva-Mazhenkovska ◽  
Vesna Janevska ◽  
Gordana Petrushevska ◽  
Liljana Spasevska ◽  
Neli Basheska
Keyword(s):  
Immune Cells ◽  
Complex Structure ◽  
Tumor Development ◽  
Morphological Characteristics ◽  
Basal Membrane ◽  
Short Review ◽  
Invasion And Metastasis ◽  
Genetic Changes ◽  
Cancer Associated Fibroblast ◽  
Skin Squamous Cell Carcinoma

Abstract The stroma of the neoplasm is a highly complex structure built by: specialized mesenchymal cells typical for each tissue surroundings, cancer associated fibroblast/myofibroblast, congenital or acquired immune cells, vascular network with endothelial cells and pericytes, mastocytes, macrophages, leukocytes and adipocytes, all together incorporated in the extracellular matrix. Each neoplasm produces its own unique microenvironment where the tumor grows and modifies. Although most of the cells of the host in the stroma have compulsory tumor suppressor ability, the stroma is changing during the malignant process and it even promotes growth, invasion and metastasis. Genetic changes that occur during the development of the cancer, which are guided by the malignant cells lead to changes in the stroma of the host that will overtake it and adjust it to their own needs. In the early stages of the tumor development and invasion, the basal membrane is degraded and the stroma becomes active and contains an increased number of fibroblasts, inflammatory infiltrate and newly composed capillaries which come into direct contact with the tumor cells. These changes lead to cancer invasion.

Sign in / Sign up

Export Citation Format

Share Document