Pituitary tumor transforming gene binding factor (PBF): a novel modulator of iodide uptake and target for Src phosphorylation in breast cancer

2015 ◽  
Author(s):  
Vikki Poole ◽  
Alice Fletcher ◽  
Bhavika Modasia ◽  
Neil Sharma ◽  
Rebecca Thompson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pituitary Tumor ◽  
Iodide Uptake ◽  
Pituitary Tumor Transforming Gene ◽  
Binding Factor ◽  
Transforming Gene

scholarly journals Pituitary Tumor Transforming Gene Binding Factor: A New Gene in Breast Cancer

2010 ◽  
Vol 70 (9) ◽  
pp. 3739-3749 ◽  
Author(s):  
Rachel J. Watkins ◽  
Martin L. Read ◽  
Vicki E. Smith ◽  
Neil Sharma ◽  
Gary M. Reynolds ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Pituitary Tumor ◽  
Pituitary Tumor Transforming Gene ◽  
Binding Factor ◽  
New Gene ◽  
Transforming Gene

scholarly journals Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients

2020 ◽  
Vol 17 (18) ◽  
pp. 3112-3124
Author(s):  
Chung-Che Wu ◽  
Titus Ime Ekanem ◽  
Nam Nhut Phan ◽  
Do Thi Thuy Loan ◽  
Sz-Ying Hou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Pituitary Tumor ◽  
Breast Cancer Patients ◽  
Pituitary Tumor Transforming Gene ◽  
Gene Signatures ◽  
Clinical Breast ◽  
Transforming Gene

scholarly journals The first reported mutations in the pituitary tumor-transforming gene binding factor

2014 ◽  
Author(s):  
Waraporn Imruetaicharoenchoke ◽  
Martin Read ◽  
Joel Smith ◽  
Vicki Smith ◽  
Bhavika Modasia ◽  
...  
Keyword(s):  
Pituitary Tumor ◽  
Pituitary Tumor Transforming Gene ◽  
Binding Factor ◽  
Transforming Gene

Pituitary tumor-transforming gene and its binding factor in endocrine cancer

2010 ◽  
Vol 12 ◽  
Author(s):  
Vicki E. Smith ◽  
Jayne A. Franklyn ◽  
Christopher J. McCabe
Keyword(s):  
Pituitary Tumor ◽  
Current Knowledge ◽  
Cellular Transformation ◽  
Ovarian Carcinomas ◽  
Pituitary Tumor Transforming Gene ◽  
Multifunctional Protein ◽  
Binding Factor ◽  
Transforming Gene

The pituitary tumor-transforming gene (PTTG1) encodes a multifunctional protein (PTTG) that is overexpressed in numerous tumours, including pituitary, thyroid, breast and ovarian carcinomas. PTTG induces cellular transformation in vitro and tumourigenesis in vivo, and several mechanisms by which PTTG contributes to tumourigenesis have been investigated. Also known as the human securin, PTTG is involved in cell cycle regulation, controlling the segregation of sister chromatids during mitosis. This review outlines current information regarding PTTG structure, expression, regulation and function in the pathogenesis of neoplasia. Recent progress concerning the use of PTTG as a prognostic marker or therapeutic target will be considered. In addition, the PTTG binding factor (PBF), identified through its interaction with PTTG, has also been established as a proto-oncogene that is upregulated in several cancers. Current knowledge regarding PBF is outlined and its role both independently and alongside PTTG in endocrine and related cancers is discussed.

Characterising the functional significance of the first reported mutations in the pituitary tumor-transforming gene binding factor

2015 ◽  
Author(s):  
Waraporn Imruetaicharoenchoke ◽  
Rachel Watkins ◽  
Bhavika Modasia ◽  
Vikki Poole ◽  
Alice Fletcher ◽  
...  
Keyword(s):  
Pituitary Tumor ◽  
Functional Significance ◽  
Pituitary Tumor Transforming Gene ◽  
Binding Factor ◽  
Transforming Gene

scholarly journals Pituitary Tumor-Transforming Gene 1 Is Expressed in Primary Ductal Breast Carcinoma, Lymph Node Infiltration, and Distant Metastases

2013 ◽  
Vol 35 ◽  
pp. 267-272 ◽  
Author(s):  
Fabio Grizzi ◽  
Sonia Di Biccari ◽  
Barbara Fiamengo ◽  
Sanja Štifter ◽  
Piergiuseppe Colombo
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Breast Carcinoma ◽  
Cancer Cells ◽  
Pituitary Tumor ◽  
Breast Cancer Cells ◽  
Distant Metastases ◽  
Pituitary Tumor Transforming Gene ◽  
Ductal Breast Carcinoma ◽  
Transforming Gene

Despite the advances that have been made in the fields of molecular and cell biology, there is still considerable debate explaining how the breast cancer cells progress through carcinogenesis and acquire their metastatic ability. The lack of preventive methods and effective therapies underlines the pressing need to identify new biomarkers that can aid early diagnosis and may be targets for effective therapeutic strategies. In this study we explore the pituitary tumor-transforming gene 1 (PTTG1) expression in primary ductal breast carcinoma, lymph node infiltration, and distant metastases. Three human cell lines, 184B5 derived from normal mammary epithelium, HCC70 from a primary ductal carcinoma, and MDA-MB-361 from a breast metastasis, were used for quantifying PTTG1 mRNA expression. The PTTG1 immunohistochemical expression was carried out on specimens taken from eight patients with invasive ductal breast cancer who underwent surgical treatment and followup for five years retrospectively selected. The study demonstrated that PTTG1 is expressed gradually in primary ductal breast carcinoma, lymph node infiltration, and distant metastases. Our findings suggest that the immunohistochemical evaluation of PTTG1 expression might be a powerful biomarker of recognition and quantification of the breast cancer cells in routine pathological specimens and a potential target for developing an effective immunotherapeutic strategy for primary and metastatic breast cancer.

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