scholarly journals Pituitary tumor transforming gene binding factor (PBF) is required for androgen-induced prostate cancer proliferation and invasion

Neoplasma ◽  
2019 ◽  
Vol 66 (03) ◽  
pp. 327-335
Author(s):  
S. Q. HUANG ◽  
B. WANG ◽  
Q. J. LIAO ◽  
C. X. SHEN ◽  
W. B. LI
Keyword(s):  
Prostate Cancer ◽  
Pituitary Tumor ◽  
Cancer Proliferation ◽  
Pituitary Tumor Transforming Gene ◽  
Binding Factor ◽  
Transforming Gene ◽  
Proliferation And Invasion

Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13

Tumor Biology ◽  
2015 ◽  
Vol 37 (12) ◽  
pp. 15495-15500 ◽  
Author(s):  
Yun-Hua Lin ◽  
Yong Tian ◽  
Jun-Sheng Wang ◽  
Yong-Guang Jiang ◽  
Yong Luo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Pituitary Tumor ◽  
Prostate Cancer Cells ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene

scholarly journals The first reported mutations in the pituitary tumor-transforming gene binding factor

2014 ◽  
Author(s):  
Waraporn Imruetaicharoenchoke ◽  
Martin Read ◽  
Joel Smith ◽  
Vicki Smith ◽  
Bhavika Modasia ◽  
...  
Keyword(s):  
Pituitary Tumor ◽  
Pituitary Tumor Transforming Gene ◽  
Binding Factor ◽  
Transforming Gene

Pituitary tumor-transforming gene and its binding factor in endocrine cancer

2010 ◽  
Vol 12 ◽  
Author(s):  
Vicki E. Smith ◽  
Jayne A. Franklyn ◽  
Christopher J. McCabe
Keyword(s):  
Pituitary Tumor ◽  
Current Knowledge ◽  
Cellular Transformation ◽  
Ovarian Carcinomas ◽  
Pituitary Tumor Transforming Gene ◽  
Multifunctional Protein ◽  
Binding Factor ◽  
Transforming Gene

The pituitary tumor-transforming gene (PTTG1) encodes a multifunctional protein (PTTG) that is overexpressed in numerous tumours, including pituitary, thyroid, breast and ovarian carcinomas. PTTG induces cellular transformation in vitro and tumourigenesis in vivo, and several mechanisms by which PTTG contributes to tumourigenesis have been investigated. Also known as the human securin, PTTG is involved in cell cycle regulation, controlling the segregation of sister chromatids during mitosis. This review outlines current information regarding PTTG structure, expression, regulation and function in the pathogenesis of neoplasia. Recent progress concerning the use of PTTG as a prognostic marker or therapeutic target will be considered. In addition, the PTTG binding factor (PBF), identified through its interaction with PTTG, has also been established as a proto-oncogene that is upregulated in several cancers. Current knowledge regarding PBF is outlined and its role both independently and alongside PTTG in endocrine and related cancers is discussed.

Characterising the functional significance of the first reported mutations in the pituitary tumor-transforming gene binding factor

2015 ◽  
Author(s):  
Waraporn Imruetaicharoenchoke ◽  
Rachel Watkins ◽  
Bhavika Modasia ◽  
Vikki Poole ◽  
Alice Fletcher ◽  
...  
Keyword(s):  
Pituitary Tumor ◽  
Functional Significance ◽  
Pituitary Tumor Transforming Gene ◽  
Binding Factor ◽  
Transforming Gene
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