Relationship between steroid hormones and metabolic profile in women with polycystic ovary syndrome

2017 ◽  
Author(s):  
Zora Lazurova ◽  
Jana Figurova ◽  
Simona Ujhazi ◽  
Jana Mašlankova ◽  
Silvia Toporcerova ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Steroid Hormones ◽  
Metabolic Profile ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Global methylation pattern and endocrine-metabolic profile during early infancy and puberty in sons born to women with polycystic ovary syndrome (PCOS)

2017 ◽  
Author(s):  
Teresa Sir-Petermann ◽  
Nicolas Crisosto ◽  
Barbara Echiburu ◽  
Manuel Maliqueo ◽  
Francisco Perez-Bravo ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Metabolic Profile ◽  
Polycystic Ovary ◽  
Methylation Pattern ◽  
Early Infancy ◽  
Ovary Syndrome ◽  
Global Methylation

scholarly journals Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Zora Lazúrová ◽  
Jana Figurová ◽  
Beáta Hubková ◽  
Jana Mašlanková ◽  
Ivica Lazúrová
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Bisphenol A ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Suppressive Effect ◽  
Human Reproduction ◽  
Control Group ◽  
Ovary Syndrome ◽  
Ovarian Steroidogenesis ◽  
The Relationship

Abstract Objectives There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. Aim of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Second aim was to assess the relationship of U-BPA to ovarian steroidogenesis in the group with PCOS. Methods Eighty six Caucasian women (age 28.5 ± 5.1 years) diagnosed with PCOS and 32 controls of age 24.9 ± 4.4 years were included in the study. Fasting blood samples were analyzed for biochemical parameters and steroid hormones. U-BPA was measured in the morning urine sample using high pressure liquid chromatography. Results PCOS women had significantly higher U-BPA as compared with control group (p=0.0001). Those with high levels of U-BPA (U-BPA ≥2.14 ug/g creatinine) demonstrated higher serum insulin (p=0.029) and HOMA IR (p=0.037), lower serum estrone (p=0.05), estradiol (p=0.0126), FSH (p=0.0056), and FAI (p=0.0088), as compared with low-BPA group (U- BPA <2.14 ug/g creatinine). In PCOS women, U-BPA positively correlated with age (p=0.0026; R2=0.17), negatively with estradiol (p=0.0001, R2=0.5), testosterone (p=0.0078, R2=0.15), free-testosterone (p=0.0094, R2=0.12) and FAI (p=0.0003, R2=0.32), respectively. Conclusions PCOS women have significantly higher U-BPA concentrations than healthy controls. U-BPA positively correlates with age and negatively with ovarian steroid hormones suggesting a possible suppressive effect of bisphenol A on ovarian steroidogenesis.

scholarly journals Irregular cycles and steroid hormones in polycystic ovary syndrome

2005 ◽  
Vol 20 (9) ◽  
pp. 2402-2408 ◽  
Author(s):  
Suhail A.R. Doi ◽  
Mona Al-Zaid ◽  
Philip A. Towers ◽  
Christopher J. Scott ◽  
Kamal A.S. Al-Shoumer
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Steroid Hormones ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Phenotype and metabolic profile of South Asian women with polycystic ovary syndrome (PCOS): results of a large database from a specialist Endocrine Clinic

2010 ◽  
Vol 26 (1) ◽  
pp. 202-213 ◽  
Author(s):  
C. N. Wijeyaratne ◽  
R. d. A. Seneviratne ◽  
S. Dahanayake ◽  
V. Kumarapeli ◽  
E. Palipane ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
South Asian ◽  
Metabolic Profile ◽  
Polycystic Ovary ◽  
Asian Women ◽  
South Asian Women ◽  
Large Database ◽  
Ovary Syndrome

Dehydroepiandrosterone sulfate/free androgen index ratio predicts a favorable metabolic profile in patients with polycystic ovary syndrome

2018 ◽  
Vol 35 (2) ◽  
pp. 128-132 ◽  
Author(s):  
Ahmet Nadir ◽  
Sule Temizkan ◽  
Aysenur Ozderya ◽  
Osman Temizkan ◽  
Ekrem Orbay ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Metabolic Profile ◽  
Polycystic Ovary ◽  
Dehydroepiandrosterone Sulfate ◽  
Ovary Syndrome ◽  
Free Androgen Index ◽  
Index Ratio

scholarly journals Arterial hypertension and metabolic profile in patients with polycystic ovary syndrome

2013 ◽  
Vol 35 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Renata do Sacramento Monte de Oliveira ◽  
Renato Galvão Redorat ◽  
Gisele Hart Ziehe ◽  
Vera Aleta Mansur ◽  
Flávia Lúcia Conceição
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Arterial Hypertension ◽  
Metabolic Profile ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome

2014 ◽  
Vol 180 ◽  
pp. 56-60 ◽  
Author(s):  
S.A. Yilmaz ◽  
O.S. Kerimoglu ◽  
A.T. Pekin ◽  
F. Incesu ◽  
N.U. Dogan ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Metabolic Profile ◽  
Polycystic Ovary ◽  
Ovary Syndrome
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