scholarly journals PROMPT: a prospective study to assess efficacy and safety of metyrapone in endogenous Cushing's syndrome

2018 ◽  
Author(s):  
Lynnette Nieman ◽  
Baris Akinci ◽  
Albert Beckers ◽  
Marek Bolanowski ◽  
Felicia Alexandra Hanzu ◽  
...  
Keyword(s):  
Prospective Study ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Efficacy And Safety ◽  
A Prospective Study

Cushing's syndrome: A prospective study of diagnostic methods

1973 ◽  
Vol 55 (5) ◽  
pp. 621-630 ◽  
Author(s):  
Richard L. Eddy ◽  
A.Lloyd Jones ◽  
Paul F. Gilliland ◽  
Jesse D. Ibarra ◽  
John Q. Thompson ◽  
...  
Keyword(s):  
Prospective Study ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Diagnostic Methods ◽  
A Prospective Study

Cushing's Syndrome and Depression—A Prospective Study of 26 Patients

1983 ◽  
Vol 142 (1) ◽  
pp. 16-19 ◽  
Author(s):  
William F. Kelly ◽  
Stuart A. Checkley ◽  
David A. Bender ◽  
Keith Mashiter
Keyword(s):  
Prospective Study ◽  
Cushing’S Syndrome ◽  
Rating Scale ◽  
Urinary Free Cortisol ◽  
Cushing's Syndrome ◽  
Depressive Illness ◽  
Pituitary Tumours ◽  
Free Cortisol ◽  
A Prospective Study ◽  
Hamilton Rating Scale

SummaryOf 26 patients with active Cushing's syndrome assessed before and at three and 12 months after treatment, 21 had pituitary-dependent disease. Median urinary free Cortisol values (per 24 hours) were 680, 180 and 200 nmol at zero, three and 12 months (normal <270 nmol), with significant improvement (P <0.001) at three and 12 months. Depression on the Hamilton rating scale was significantly less at three months (P <0.01) and at 12 months (P <0.001). We have already demonstrated that some patients with Cushing's syndrome have PSE diagnoses of depression and are more depressed than patients with other pituitary tumours. This is the firmest evidence to date that when Cushing's syndrome occurs it commonly causes depressive illness.

scholarly journals Treatment of Diabetic Foot Infections: A Prospective Study Highlighting the Efficacy and Safety of Moxifloxacin

2018 ◽  
Vol 8 (2-3) ◽  
pp. 32-36 ◽  
Author(s):  
Bikha Ram Devrajani ◽  
Samar Raza ◽  
Rubina Khushik ◽  
Syed Zulfiquar Ali Shah ◽  
Sanam Mari ◽  
...  
Keyword(s):  
Prospective Study ◽  
Diabetic Foot ◽  
Efficacy And Safety ◽  
Diabetic Foot Infections ◽  
A Prospective Study

Efficacy and Safety of Deferasirox in β-Thalassemia Major Patients in Iran: A Prospective Study from a Single referral Center in Iran

2014 ◽  
Vol 31 (1) ◽  
pp. 76-86 ◽  
Author(s):  
Samin Alavi ◽  
Maryam Ebadi ◽  
Farid Ghazizadeh ◽  
Mohammad Taghi Arzanian ◽  
Bibishahin Shamsian ◽  
...  
Keyword(s):  
Prospective Study ◽  
Thalassemia Major ◽  
Efficacy And Safety ◽  
Referral Center ◽  
A Prospective Study

scholarly journals Aberrant cortisol regulations in bilateral macronodular adrenal hyperplasia: a frequent finding in a prospective study of 32 patients with overt or subclinical Cushing's syndrome

2010 ◽  
Vol 163 (1) ◽  
pp. 129-138 ◽  
Author(s):  
Rossella Libé ◽  
Joël Coste ◽  
Laurence Guignat ◽  
Frédérique Tissier ◽  
Hervé Lefebvre ◽  
...  
Keyword(s):  
Functional Status ◽  
Cushing’S Syndrome ◽  
Hormone Receptors ◽  
Cushing's Syndrome ◽  
Receptor Expression ◽  
Adrenal Hyperplasia ◽  
Cortisol Responses ◽  
A Prospective Study ◽  
Underlying Pathophysiology

ContextACTH-independent macronodular adrenal hyperplasia (AIMAH) is a rare and heterogeneous condition characterized by abnormal steroid production. Cortisol secretion can be regulated by aberrant hormone receptors.ObjectiveA large series of patients with AIMAH were evaluated to provide information on the prevalence and profile of aberrant regulations, in relation with the functional status.Design and patientsThirty-two consecutive patients with AIMAH were prospectively studied: 10 had a Cushing's syndrome (CS), and 22 had a subclinical CS (SCS).MethodsA baseline endocrine evaluation was followed by an in vivo protocol in search of aberrant cortisol responses (seven provocative tests). An acute inhibition test with the somatostatin analog octreotide was also performed.ResultsAt least one aberrant cortisol response was identified in 28 of 32 (87%) patients. The overall prevalence of aberrant responses was independent of the functional status. Responses to the upright posture and to metoclopramide were frequently observed (67 and 56% respectively). A glucagon response was frequently observed in the SCS group (58%). A cortisol inhibition by octreotide was specifically found in the three CS patients who positively responded to the mixed meal, and was observed also in 12 of 13 (92%) patients with SCS.ConclusionsCortisol responses indicative of aberrant receptor expression were highly prevalent in AIMAH. Thorough phenotyping of AIMAH may help uncover the underlying pathophysiology.

Efficacy and safety of prescription omega-3-acid ethyl esters for the prevention of recurrent symptomatic atrial fibrillation: A prospective study

2009 ◽  
Vol 158 (2) ◽  
pp. 163-169.e3 ◽  
Author(s):  
Craig M. Pratt ◽  
James A. Reiffel ◽  
Kenneth A. Ellenbogen ◽  
Gerald V. Naccarelli ◽  
Peter R. Kowey
Keyword(s):  
Atrial Fibrillation ◽  
Prospective Study ◽  
Ethyl Esters ◽  
Efficacy And Safety ◽  
Omega 3 ◽  
A Prospective Study
Sign in / Sign up

Export Citation Format

Share Document