Studies of the novel essential invadolysin metalloprotease in human blood

2021 ◽  
Author(s):  
Linda Feng ◽  
Margarete Heck
Keyword(s):  
Human Blood ◽  
The Novel

scholarly journals Separation of Biological Entities from Human Blood by Using Magnetic Nanocomposites Obtained from Zeolite Precursors

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1803
Author(s):  
Serena Esposito ◽  
Antonello Marocco ◽  
Gianfranco Dell’Agli ◽  
Barbara Bonelli ◽  
Franca Mannu ◽  
...  
Keyword(s):  
Human Blood ◽  
Chemical Properties ◽  
Industrial Process ◽  
High Sensitivity ◽  
Point Of View ◽  
The Novel ◽  
Magnetic Adsorbents ◽  
Physico Chemical ◽  
Magnetic Metal ◽  
Biological Entities

In this work, three novel magnetic metal–ceramic nanocomposites were obtained by thermally treating Fe-exchanged zeolites (either A or X) under reducing atmosphere at relatively mild temperatures (750–800 °C). The so-obtained materials were thoroughly characterized from the point of view of their physico-chemical properties and, then, used as magnetic adsorbents in the separation of the target gene factors V and RNASE and of the Staphylococcus aureus bacteria DNA from human blood. Such results were compared with those obtained by using a top ranking commercial separation system (namely, SiMAG-N-DNA by Chemicell). The results obtained by using the novel magnetic adsorbents were similar to (or even better than) those obtained by using the commercial system, both during manual and automated separations, provided that a proper protocol was adopted. Particularly, the novel magnetic adsorbents showed high sensitivity during tests performed with small volumes of blood. Finally, the feasible production of such magnetic adsorbents by an industrial process was envisaged as well.

The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity

2000 ◽  
Vol 43 (21) ◽  
pp. 3970-3980 ◽  
Author(s):  
David Bom ◽  
Dennis P. Curran ◽  
Stefan Kruszewski ◽  
Stephen G. Zimmer ◽  
J. Thompson Strode ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Human Blood ◽  
The Novel

Octavia Butler’s Vampiric Vision

2016 ◽  
Author(s):  
Timothy M. Robinson
Keyword(s):  
Science Fiction ◽  
Human Blood ◽  
Slave Narrative ◽  
The Novel ◽  
Black Girl ◽  
Tragic Mulatto

Octavia Butler’s Fledgling (2005) chronicles the story of Shori Matthews, a 53-year-old vampire who looks like a 10-year-old black girl. Shori awakens with amnesia and physical scarring as a result of an attack from unknown assailants. While healing, she is hunted by clandestine factions of white-skinned vampires called the Ina. Shori later discovers that she is a product of amalgamated Ina and human blood. This chapter argues that Shori is a tragic mulatto figure in the vein of characters in novels like Iola Leroy, Incidents in the Life of a Slave Girl,Our Nig, and Clotelle but written in the genre of science fiction and fantasy. The novel seems especially concerned with effects of familial and cultural devastation, trauma, miscegenation and xenophobia. While these are primary concerns of the slave narrative, these elements are also reflective of oppressive forces in modern societies that continue to play out master-slave relationships, often in concealed ways.

scholarly journals The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation

1990 ◽  
Vol 269 (3) ◽  
pp. 831-834 ◽  
Author(s):  
C Sultan ◽  
M Breton ◽  
G Mauco ◽  
P Grondin ◽  
M Plantavid ◽  
...  
Keyword(s):  
Growth Factor ◽  
Human Blood ◽  
Blood Platelets ◽  
Human Platelets ◽  
Time Dependent ◽  
Platelet Derived Growth Factor ◽  
Dependent Manner ◽  
The Novel ◽  
Activated Platelets ◽  
Human Blood Platelets

Radioactive PtdIns(3)P was detected in human platelets incubated with [32P]Pi, but remained unaffected by thrombin treatment. In contrast, [32P]PtdIns(3,4)P2 was absent from resting platelets, but was produced by thrombin-activated platelets in a dose- and time-dependent manner. [32P]PtdInsP3 was never found under these conditions. These changes are similar to those elicited in other cells by platelet-derived growth factor or the oncogene product pp60c-src.

In vitro pharmacokinetic study of the novel anticancer agent E7070: red blood cell and plasma protein binding in human blood

2003 ◽  
Vol 14 (6) ◽  
pp. 405-410 ◽  
Author(s):  
H. J. G. D. van den Bongard ◽  
D. Pluim ◽  
R. C. A. M. van Waardenburg ◽  
M. Ravic ◽  
J. H. Beijnen ◽  
...  
Keyword(s):  
Blood Cell ◽  
Protein Binding ◽  
Plasma Protein Binding ◽  
Human Blood ◽  
Pharmacokinetic Study ◽  
Red Blood Cell ◽  
Anticancer Agent ◽  
The Novel ◽  
Blood Cell And Plasma

scholarly journals The peptidylglycine alpha-amidating monooxygenase, PAM, is differentially expressed in viral co-infections.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Microarray Data ◽  
Human Blood ◽  
Influenza A ◽  
Influenza Season ◽  
The Novel ◽  
Human Coronavirus ◽  
Transcriptional Changes ◽  
One Year ◽  
Novel Coronavirus

Co-infection is defined by the infection of a host or cell by more than one pathogen (1, 2). Infections from the novel coronavirus severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 (3), have resulted in the death of more than 200,000 Americans (4) and over 1,000,000 people worldwide (5) in less than one year. An upcoming influenza season raises the prospect of potential complications arising from co-infections involving SARS-CoV-2 (6). We mined published microarray data (7) to discover transcriptional features of viral co-infection in the blood of human patients. We identified the peptidylglycine alpha-amidating monooxygenase, PAM, as among the genes whose expression was most different in the blood of patients with a variety of viral co-infections, including co-infection of human coronavirus OC43 and influenza A. Transcriptional changes in PAM appeared to be specific to co-infection settings. PAM may be of relevance to fundamental transcriptional biology underlying viral co-infections of human blood.

scholarly journals Anticoagulative and anticomplementary activity of endogenous inhibitor preparation from hepatopancreas of red king crab (paralithosed camtschaticus) towards human blood

2012 ◽  
Vol 58 (2) ◽  
pp. 176-188
Author(s):  
M.V. Balashova ◽  
L.V. Lyutova ◽  
Yu.A. Rudenskaya ◽  
V.A. Isayev ◽  
S.S. Andina ◽  
...  
Keyword(s):  
Human Blood ◽  
Competitive Inhibition ◽  
Cysteine Proteases ◽  
Human Blood Plasma ◽  
Red King Crab ◽  
The Novel ◽  
C1 Inhibitor ◽  
King Crab ◽  
Combined Action ◽  
Suicide Mechanism

Serpins (SERine Protease INhibitors) - is large and diverse group of proteins with similar structures, which can inhibit both serine and cysteine proteases by an irreversible suicide mechanism. A novel serpin from hepatopancreas of Red King Crab (Paralithosed camtschaticus) was obtained and was studied its effect on the process of human blood plasma clotting. The investigated serpin shows a noticeable anticoagulative activity, which increases dramatically in the combined action with heparine. Though the inhibitor has almost no effect on thrombin, it inhibits C1s (C1-esterase). We studied the action of the serpin from P. camtschaticus on C1s via its competitive inhibition by C1 inhibitor and the novel enzyme. The calculated inhibition constant of the serpin from P. camtschaticus towards C1s is 2,02±0,71 М. Unlike C1 inhibitor, the novel serpin from P. camtschaticus doesn`t suppress fibrinolysis and at the same time prevents blood clotting. These features may be of interest for medical purposes.

Study of mesoporous magnesium carbonate in contact with whole human blood

RSC Advances ◽  
2016 ◽  
Vol 6 (58) ◽  
pp. 52810-52816 ◽  
Author(s):  
S. Frykstrand ◽  
J. Forsgren ◽  
O. Cheung ◽  
P. Zhang ◽  
J. Hong ◽  
...  
Keyword(s):  
Human Blood ◽  
Whole Blood ◽  
Magnesium Carbonate ◽  
The Novel

The novel mesoporous magnesium carbonate Upsalite showed anticoagulant properties when incubated with whole blood, an effect most probably due to Ca2+uptake.

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