scholarly journals The Genome Sequence of the Eastern Woodchuck (Marmota monax) – A Preclinical Animal Model for Chronic Hepatitis B

2019 ◽  
Vol 9 (12) ◽  
pp. 3943-3952 ◽  
Author(s):  
Tyler S. Alioto ◽  
Fernando Cruz ◽  
Jèssica Gómez-Garrido ◽  
Miriam Triyatni ◽  
Marta Gut ◽  
...  
Keyword(s):  
Animal Model ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Genome Sequence ◽  
Preclinical Animal Model ◽  
Marmota Monax

The Establishment and Application of Three Kinds of the SCID Mouse-Based Improved Animal Models in the Research of AIDS, Chronic Hepatitis B and C

2013 ◽  
Vol 749 ◽  
pp. 433-438
Author(s):  
Dong Liang Xie ◽  
Jun Yao He ◽  
Yan Ling Wu ◽  
Wen Zhang ◽  
Yoshimasa Tanaka
Keyword(s):  
Animal Model ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Mouse Models ◽  
Scid Mouse ◽  
Severe Combined Immunodeficiency ◽  
Small Animal ◽  
Small Animal Model ◽  
Difficult Challenge

The SCID mouse (severe combined immunodeficiency mouse) has been used as a small animal model in the analysis of human pathophysiology and preclinical experiment for many years. As the most difficult challenge faced in the research of AIDS, chronic hepatitis B and chronic hepatitis C is the lack of appropriate small animal model, researchers have always attempted to develop a series of mouse models based on the improvements of the SCID mouse. This review focuses on the developments and applications of such SCID mouse models in three types of the above chronic infectious diseases.

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