scholarly journals Atrioventricular conduction defect associated with severe hyponatremia

2018 ◽  
Vol 91 (3) ◽  
pp. 342-345
Author(s):  
Turgut Karabag ◽  
Belma Kalayci ◽  
Muhammet Rasit Sayin ◽  
Turgay Erten
Keyword(s):  
Elderly Patient ◽  
Heart Disease ◽  
Atrioventricular Block ◽  
The Elderly ◽  
Complete Atrioventricular Block ◽  
Severe Hyponatremia ◽  
Electrolyte Disorder ◽  
Conduction Defect ◽  
Sodium Replacement ◽  
Complete Atrioventricular

Hyponatremia is the most common electrolyte disorder among hospitalized patients and in the clinical setting. Patients with hyponatremia may develop a variety of symptoms, primarily neurological and gastrointestinal. Hyponatremia is more frequently encountered in patients with an underlying heart disease, particularly in the elderly. We hereby present a case of complete atrioventricular block in an elderly patient who had undergone aortic valve replacement and had been using thiazide. Complete atrioventricular block improved after sodium replacement therapy and no other cause of electrolyte disorder was documented. 

scholarly journals Transplacental Fetal Treatment Improves the Outcome of Prenatally Diagnosed Complete Atrioventricular Block Without Structural Heart Disease

Circulation ◽  
2004 ◽  
Vol 110 (12) ◽  
pp. 1542-1548 ◽  
Author(s):  
Edgar T. Jaeggi ◽  
Jean-Claude Fouron ◽  
Earl D. Silverman ◽  
Greg Ryan ◽  
Jeffrey Smallhorn ◽  
...  
Keyword(s):  
Heart Disease ◽  
Atrioventricular Block ◽  
Structural Heart Disease ◽  
Complete Atrioventricular Block ◽  
Complete Atrioventricular

Diagnosis, Management, and Long-Term Results of Patients with Congenital Complete Atrioventricular Block

PEDIATRICS ◽  
1982 ◽  
Vol 69 (6) ◽  
pp. 728-733
Author(s):  
William W. Pinsky ◽  
Paul C. Gillette ◽  
Arthur Garson ◽  
Dan G. McNamara
Keyword(s):  
Heart Disease ◽  
Atrioventricular Block ◽  
Long Term Results ◽  
Complete Atrioventricular Block ◽  
Transposition Of Great Arteries ◽  
Congenital Complete Atrioventricular Block ◽  
Bundle Of His ◽  
Complete Atrioventricular

Sixty-five patients with congenital complete atrioventricular block have been studied. The median age at time of diagnosis was 7 months with 26 infants being diagnosed prior to 1 month of age. Anatomic heart disease was present in 25/65 (39%) infants, with ventricular inversion/L-transposition of great arteries complex occurring in 20/25 infants (80%). The site of block was above the bundle of His in 11 of 18 (61%) patients studied, in the bundle of His in three of 18 (17%), and below the bundle of His in two of 18 (11%). Permanent pacemakers were implanted in 17 (26%). Ten patients (15%) have died. The highest risk was in patients with anatomic heart disease and patients diagnosed early in life.

scholarly journals A case of complete atrioventricular block with extremely high blood concentration of azelnidipine

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Naohito Ide ◽  
Ayaka Mochizuki ◽  
Yoshiyuki Kagawa ◽  
Masaharu Ito
Keyword(s):  
Adverse Effect ◽  
Atrioventricular Block ◽  
Medical Center ◽  
Extended Period ◽  
The Elderly ◽  
Cytochrome P450 Enzyme ◽  
Complete Atrioventricular Block ◽  
P450 Enzyme ◽  
Cyp3a4 Inhibitors ◽  
Complete Atrioventricular

Abstract Background Azelnidipine, a dihydropyridine calcium channel blocker (CCB), has less adverse effects (e.g. hot flushes and reflex tachycardia) compared to other dihydropyridine CCBs. Azelnidipine has been reported to reduce heart rate as opposed to inducing tachycardia. No evidence of bradycardia or complete atrioventricular block (CAVB) with azelnidipine treatment has been reported. Case presentation In the present study, a 92-year-old woman was diagnosed with CAVB while taking azelnidipine and simvastatin for an extended period of time, and referred to our medical center. It was thought that the CAVB may have been an adverse effect of azelnidipine treatment. Specifically, it was considered that in this patient, one of the causes might be the concomitant use of simvastatin inhibiting the metabolism of azelnidipine by cytochrome P450 enzyme 3A4. Consequently, it was suggested to the patient’s physician that the patient’s serum azelnidipine levels be measured and treatment with azelnidipine and simvastatin be discontinued. The patient’s serum concentration of azelnidipine at the time of her visit to our center was 63.4 ng/mL, higher than the normal acceptable level. There was no occurrence of CAVB for 4 weeks, to present, following discontinuation of azelnidipine and simvastatin treatment. Conclusions Azelnidipine has a different mechanism of action that other CCBs. In very rare cases, it may cause CAVB when combined with CYP3A4 inhibitors. If a patient taking azelnidipine is diagnosed with CAVB, physicians should suspect that the condition may be an adverse effect of azelnidipine and should consider discontinuing azelnidipine. And, in the elderly, it is necessary to avoid concomitant use of CYP3A4 inhibitors.

scholarly journals Severe Hyponatremia Leading to Complete Atrioventricular Block

2016 ◽  
Vol 129 (10) ◽  
pp. e243-e244 ◽  
Author(s):  
Jan Kottwitz ◽  
Deniz Akdis ◽  
Firat Duru ◽  
Bettina Heidecker
Keyword(s):  
Atrioventricular Block ◽  
Complete Atrioventricular Block ◽  
Severe Hyponatremia ◽  
Complete Atrioventricular

Complete Atrioventricular Block in an Elderly Patient Treated with Low-Dose Lacosamide

2018 ◽  
Vol 18 (6) ◽  
pp. 579-582 ◽  
Author(s):  
Célia Lachuer ◽  
Jennifer Corny ◽  
Yvonnick Bézie ◽  
Sadri Ferchichi ◽  
Bernard Durand-Gasselin
Keyword(s):  
Elderly Patient ◽  
Atrioventricular Block ◽  
Low Dose ◽  
Complete Atrioventricular Block ◽  
Complete Atrioventricular
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