Partial Splenic Embolization for Hypersplenism in Cirrhotic Patients. A Case Series

2014 ◽  
Vol 23 (2) ◽  
pp. 215-218 ◽  
Author(s):  
Secil Omer ◽  
Octavian Zara ◽  
Claudia Iacobescu ◽  
Ion Dina
Keyword(s):  
Liver Cirrhosis ◽  
Portal Hypertension ◽  
Interventional Procedure ◽  
Case Series ◽  
Favourable Outcome ◽  
High Morbidity ◽  
Severe Thrombocytopenia ◽  
Partial Splenic Embolization ◽  
Splenic Embolization ◽  
Prognosis Of Liver Cirrhosis

The prognosis of liver cirrhosis depends on the presence of its major complications as well as on other factors such as hypersplenism with thrombocytopenia. Partial splenic embolization is an effective interventional procedure performed in liver cirrhosis complicated with portal hypertension to improve the low platelet count. This technique represents an efficient alternative to splenectomy, which has major drawbacks and is associated with a high morbidity. We report a series of patients with liver cirrhosis and portal hypertension who presented with severe thrombocytopenia and were treated with partial splenic embolization eventually having a favourable outcome.

scholarly journals Partial Splenic Embolization as a Bridge to Total Knee Replacement for a Patient with Severe Thrombocytopenia due to Cirrhosis and Splenic Sequestration

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Adrianne Netterville ◽  
Ronald Lands
Keyword(s):  
Portal Hypertension ◽  
Orthopedic Surgery ◽  
Elderly Woman ◽  
Severe Thrombocytopenia ◽  
Partial Splenic Embolization ◽  
Splenic Sequestration ◽  
Remarkable Improvement ◽  
Splenic Embolization ◽  
Total Knee ◽  
Over 40 Years

Medical splenectomy by embolization was originally used to attenuate bleeding from varices in a man with cirrhosis and portal hypertension. Despite the procedure being described over 40 years ago with remarkable improvement in its safety profile and clinical outcomes since, it is still used with variable frequency because of concerns that the risk is high and the results are transient. We present the case of an elderly woman with cirrhosis, portal hypertension, and splenic sequestration who completed partial splenic embolization (PSE) with a durable hematologic response that served as a bridge which allowed her to have orthopedic surgery. A discussion with literature review follows.

scholarly journals Sustained viral response (SVR) in type C liver cirrhosis patients undergoing peginterferon α-2b/ribavirin combination therapy after partial splenic embolization

Kanzo ◽  
2011 ◽  
Vol 52 (1) ◽  
pp. 26-35
Author(s):  
Keisuke Shiina ◽  
Atsushi Naganuma ◽  
Tomofumi Takakusaki ◽  
Masashi Namikawa ◽  
Hiroki Tahara ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Combination Therapy ◽  
Sustained Viral Response ◽  
Partial Splenic Embolization ◽  
Viral Response ◽  
Splenic Embolization ◽  
Type C ◽  
Peginterferon Α

Partial splenic embolization in patients with liver cirrhosis and hepatocellular carcinoma: Effects on portal hemodynamics

1994 ◽  
Vol 1 (2) ◽  
pp. 172-175 ◽  
Author(s):  
Kazuhiro Yamashiro ◽  
Mitsuhiro Mukaiya ◽  
Hiromichi Kimura ◽  
Tadashi Katsuramaki ◽  
Kazuaki Sasaki ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Partial Splenic Embolization ◽  
Portal Hemodynamics ◽  
Splenic Embolization

631 THE EFFECT OF PARTIAL SPLENIC EMBOLIZATION FOR THROMBOCYTOPENIA IN LIVER CIRRHOSIS PATIENTS

2012 ◽  
Vol 56 ◽  
pp. S250 ◽  
Author(s):  
B.I. Kim ◽  
Y.K. Cho ◽  
H.J. Kim ◽  
J.H. Park ◽  
D.I. Park ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Partial Splenic Embolization ◽  
Splenic Embolization

scholarly journals Partial Splenic Embolization with Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma Accompanied by Thrombocytopenia

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Yoshihiko Ooka ◽  
Tetsuhiro Chiba ◽  
Sadahisa Ogasawara ◽  
Tenyu Motoyama ◽  
Eiichiro Suzuki ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Failure ◽  
Transarterial Chemoembolization ◽  
Systemic Chemotherapy ◽  
Serum Levels ◽  
Severe Thrombocytopenia ◽  
Partial Splenic Embolization ◽  
Long Term Effects ◽  
Platelet Counts ◽  
Splenic Embolization

Background. Thrombocytopenia often makes the introduction of systemic treatment difficult in patients with cirrhosis and hepatocellular carcinoma (HCC). We retrospectively evaluated the long-term effects of partial splenic embolization (PSE) with transarterial chemoembolization (TACE) in patients with HCC patients accompanied by thrombocytopenia.Patients and Methods. Twenty-one patients with HCC complicated by severe thrombocytopenia (platelet count, <5.0 × 104/mm3) were treated with PSE and TACE. Both the safety and platelet-increasing effect was evaluated in these patients.Results. Seventeen of 21 patients (81.0%) showed increased platelet counts to ≥5.0 × 104/mm3. Subsequently, 13 patients (61.9%) successfully received systemic chemotherapy. Platelet counts and serum levels of total bilirubin, as well as neutrophil counts, improved significantly one month after treatment. However, serum levels of albumin and hemoglobin decreased significantly one month after treatment. Severe adverse events, including acute liver failure and portal vein thrombus, were observed in two patients.Conclusion. PSE with selective TACE made it possible for patients with HCC and severe thrombocytopenia to receive systemic chemotherapy. Although PSE with TACE was safe and tolerable for most patients, the extent of PSE with TACE in a wide area of the liver may increase the risk for fatal liver failure.

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