scholarly journals Why it is difficult to treat and prevent drug-resistant hypertension and elevated pulse pressure: the unrecognized roles of ionized hypomagnesemia, nitric oxide, ceramides, platelet-activating factor and epigenesis

2020 ◽  
Vol 5 (2) ◽  
pp. 53-58
Author(s):  
Burton M Altura ◽  
Asefa Gebrewold ◽  
Anthony Carella ◽  
Aimin Zhang ◽  
Wenyan Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulse Pressure ◽  
Resistant Hypertension ◽  
Platelet Activating Factor ◽  
Drug Resistant

scholarly journals Baroreflex Activation Therapy for the Treatment of Drug-Resistant Hypertension: New Developments

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Teba Alnima ◽  
Peter W. de Leeuw ◽  
Abraham A. Kroon
Keyword(s):  
Resistant Hypertension ◽  
First Generation ◽  
Systolic Heart Failure ◽  
Drug Resistant ◽  
New Developments ◽  
Baroreflex Activation Therapy ◽  
Beneficial Effects ◽  
The Past ◽  
Carotid Baroreflex ◽  
Activation Therapy

In the past few years, novel accomplishments have been obtained in carotid baroreflex activation therapy (BAT) for the treatment of resistant hypertension. In addition, this field is still evolving with promising results in the reduction of blood pressure and heart rate. This overview addresses the latest developments in BAT for the treatment of drug-resistant hypertension. Although not totally understood considering the working mechanisms of BAT, it appeared to be possible to achieve at least as much efficacy of single-sided as bilateral stimulation. Therefore unlike the first-generation Rheos system, the second-generation Barostimneooperates by unilateral baroreflex activation, using a completely different carotid electrode. Also significant improvements in several cardiac parameters have been shown by BAT in hypertensive patients, which set the basis for further research to evaluate BAT as a therapy for systolic heart failure. Yet important uncertainties need to be clarified to guarantee beneficial effects; hence not all participants seem to respond to BAT.

scholarly journals Rational combination therapy in resistant arterial hypertension

2011 ◽  
Vol 17 (4) ◽  
pp. 384-390
Author(s):  
I. V. Emelianov ◽  
A. O. Konradi
Keyword(s):  
Combination Therapy ◽  
Arterial Hypertension ◽  
Resistant Hypertension ◽  
Drug Resistant ◽  
Therapeutic Approaches ◽  
Rational Combination ◽  
Resistant Arterial Hypertension

The article reviews therapy in drug-resistant hypertension. Current therapeutic approaches to treatment and rational combination therapy are discussed.

Case 16.16

2014 ◽  
pp. 789-789
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Blood Pressure ◽  
Thoracic Aorta ◽  
Resistant Hypertension ◽  
Lower Extremities ◽  
Filling Defect ◽  
Drug Resistant ◽  
Upper And Lower Extremities

82-year-old woman with drug-resistant hypertension and a blood pressure discrepancy between upper and lower extremities MIP image from 3D CE MRA of the thoracic aorta (Figure 16.16.1) shows an irregular filling defect in the distal thoracic aorta, which causes significant narrowing of the aorta. Coronal oblique reformatted image from the 3D CE MRA (...

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