Metastatic melanoma presenting as a malignant peripheral nerve sheath tumour

2021 ◽  
Vol 5 (1) ◽  
pp. 1-4
Author(s):  
David John Mackay Smith
Keyword(s):  
Peripheral Nerve ◽  
Metastatic Melanoma ◽  
Spindle Cell ◽  
Correct Diagnosis ◽  
Primary Cutaneous Melanoma ◽  
Tissue Mass ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
Spindle Cell Proliferation ◽  
Peripheral Nerve Sheath Tumour

This is a report of a metastatic melanoma presenting clinically as a soft tissue mass and histologically being diagnosed as a malignant peripheral nerve sheath tumour. In this case the metastatic melanoma was preceded by a primary cutaneous melanoma in a similar anatomical region. Histologically the tumour was characterised by a malignant-appearing Spindle cell proliferation, arranged in fascicules. There was no evidence of connection to a nerve, co-existent neurofibroma or stigmata of neurofibromatosis. This presentation is only infrequently mentioned in the literature and heterogeneity can make clinical and histological diagnosis of metastatic melanoma problematic. It can easily be misinterpreted without effective clinico-histological correlation, making a good working relationship between Clinician and Histopathologist essential for correct diagnosis.

Cutaneous Malignant Peripheral Nerve Sheath Tumour (Mpnst) of the Hand: A Review of Current Literature

1993 ◽  
Vol 18 (4) ◽  
pp. 478-481 ◽  
Author(s):  
M. S. E. COADY ◽  
S. POLACARZ ◽  
R. E. PAGE
Keyword(s):  
Peripheral Nerve ◽  
Upper Limb ◽  
Soft Tissues ◽  
Spindle Cell ◽  
Current Knowledge ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
Tumour Extension ◽  
Therapeutic Problem ◽  
Peripheral Nerve Sheath Tumour

Malignant peripheral nerve sheath tumours (MPNST) are spindle cell sarcomas normally situated in the deep soft tissues. Cutaneous MPNST is an uncommon variant, usually occurring in the head and neck. When it arises in the upper limb this tumour may pose a considerable diagnostic and therapeutic problem. We present a case of cutaneous MPNST arising in the hand. Tumour extension was exclusively perineural along three major nerve trunks from an interdigital origin. Current knowledge of the clinical behaviour of cutaneous MPNST is reviewed.

scholarly journals Spindle cell sarcomas, suggestive of peripheral nerve sheath tumours, arising in the tongues of two cats

2019 ◽  
Vol 5 (2) ◽  
pp. 205511691987525
Author(s):  
Melanie J Dobromylskyj ◽  
Fernando Martinez ◽  
Anna Lovell
Keyword(s):  
Peripheral Nerve ◽  
Immunohistochemical Staining ◽  
Spindle Cell ◽  
Nerve Sheath Tumour ◽  
Histological Features ◽  
Case Summary ◽  
Nerve Sheath ◽  
Histological Malignancy ◽  
Tip Of The Tongue ◽  
Peripheral Nerve Sheath Tumour

Case summary Two domestic shorthair cats, one an 11-year-old female neutered cat and the other a 13-year-old male neutered cat, presented with partly raised, well-demarcated masses at the rostral tip of the tongue. Histological examination and immunohistochemical staining were consistent with sarcomas, and were most suggestive of peripheral nerve sheath tumours. One tumour had histological features consistent with a malignant peripheral nerve sheath tumour (PNST). Relevance and novel information Feline PNSTs arising on the tongue are rarely described in the published literature, and, to our knowledge, a case of malignant PNST originating at this site has not been described to date. Therefore, this represents a new differential diagnosis for cats presenting with a lingual mass. Regardless of histological malignancy, in cats these tumours have the potential for local recurrence but appear very unlikely to metastasise.

scholarly journals The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Luting Zhou ◽  
Anran Wang ◽  
Guoli Yu ◽  
Jun Zhou ◽  
Haimin Xu ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Synovial Sarcoma ◽  
Clinical Significance ◽  
Spindle Cell ◽  
Dermatofibrosarcoma Protuberans ◽  
Dedifferentiated Liposarcoma ◽  
Spindle Cell Lipoma ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
Peripheral Nerve Sheath Tumour

The expression of TFE3 (transcription factor E3) in solitary fibrous tumours (SFTs) and their histologic mimickers was investigated, and the diagnostic value and clinical significance of TFE3 nuclear expression in SFTs were explored. Immunohistochemical analysis for TFE3 was performed on 50 cases of SFTs that were surgically resected. The controls were sample tissues from malignant peripheral nerve sheath tumour, synovial sarcoma, dedifferentiated liposarcoma, spindle cell lipoma, and dermatofibrosarcoma protuberans. The survival of patients with TFE3-positive and TFE3-negative expressions was assessed through the Kaplan-Meier analysis. In 44 of 50 (88%) SFTs, nuclear immunoreactivity for TFE3 was detected. The TFE3 expression was negative in all samples of synovial sarcoma, malignant peripheral nerve sheath tumour, dermatofibrosarcoma protuberans, and spindle cell lipoma and weakly positive in 2 of 10 cases of dedifferentiated liposarcoma. Fluorescence in situ hybridization (FISH) confirmed that the expression of the TFE3 protein is not caused by gene translocation. There was no statistical significance between the association of the TFE3 expression and SFT patient prognosis. Therefore, TFE3 is capable of enhancing the differential diagnosis of SFTs and their histologic mimickers and can be potentially used as a diagnostic marker. The findings also offer valuable insights into SFT diagnosis, aetiology, and associated molecular mechanisms.

scholarly journals Extradural Peripheral Nerve Sheath Tumour at T7 Level in a 2-Year-Old Dog

VCOT Open ◽  
2021 ◽  
Vol 04 (01) ◽  
pp. e41-e46
Author(s):  
Federica Aragosa ◽  
Chiara Caterino ◽  
Giovanni Della Valle ◽  
Ilaria D'Aquino ◽  
Dario Costanza ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Soft Tissue Mass ◽  
Resonance Imaging ◽  
Tissue Mass ◽  
Nerve Sheath Tumour ◽  
Free Interval ◽  
Nerve Sheath ◽  
Dorsal Laminectomy ◽  
Intervertebral Foramina ◽  
Peripheral Nerve Sheath Tumour

AbstractThe aim of this report is to describe an unusual localization of nerve sheath tumour (NST), clinical presentation, imaging, surgical management, and outcome in a 2-year-old dog. A 2-year-old female American Staffordshire Terrier presented with nonambulatory paraparesis, thoracolumbar hyperaesthesia, hindlimb hyperreflexia, and mild muscle atrophy. Computed tomography and magnetic resonance imaging revealed an extradural mass at T7-T8, without vertebral lesions. Surgical treatment consisted in resection of the soft tissue mass through dorsal laminectomy. The dog was ambulatory within 24 hours and free of recurrence at 18 months postoperatively. Histopathologic and features of immunohistochemistry were consistent with NST. The NST of this report was similar to those described before, but exhibited unusual characteristics, such as being extradural, without extension into intervertebral foramina, and being located in an atypical region (T7-T8). Moreover, survival time and relapse-free interval are greater than previously reported for similar cases.

scholarly journals MRI of malignant peripheral nerve sheath tumour in pericardial cavity

2018 ◽  
pp. bcr-2018-224481
Author(s):  
Ryoma Endo ◽  
Tomoko Tomioka ◽  
Ken Okada ◽  
Kanichi Inoue
Keyword(s):  
Peripheral Nerve ◽  
Nerve Sheath Tumour ◽  
Pericardial Cavity ◽  
Nerve Sheath ◽  
Peripheral Nerve Sheath Tumour

scholarly journals Malignant peripheral nerve sheath tumour of the tongue

2006 ◽  
Vol 42 (5) ◽  
pp. 210-212 ◽  
Author(s):  
Anacélia Mendes Fernandes ◽  
Aline Cristina Batista Rodrigues Johann ◽  
João Batista da Silveira-Júnior ◽  
Maria Cássia Ferreira de Aguiar ◽  
Maria Auxiliadora Vieira do Carmo ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
Peripheral Nerve Sheath Tumour
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