A Quantitative Comparison of Hemoglobin Concentration and BOLD Signal using Time-Resolved Near-Infrared Spectroscopy

In this paper, a time-domain fast gated near-infrared spectroscopy system is presented. The system is composed of a fiber-based laser providing two pulsed sources and two fast gated detectors. The system is characterized on phantoms and was tested in vivo, showing how the gating approach can improve the contrast and contrast-to-noise-ratio for detection of absorption perturbation inside a diffusive medium, regardless of source-detector separation.

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ERRATA

PEDIATRICS ◽

10.1542/peds.92.1.190 ◽

1993 ◽

Vol 92 (1) ◽

pp. 190-190

Keyword(s):

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Neurological Disorders ◽

Near Infrared ◽

Time Resolved

In the article, "A Report of the National Institute of Neurological Disorders and Stroke Workshop on Near Infrared Spectroscopy" by Hirtz (Pediatrics. 1993;91:414-417), on page 416, middle of the second paragraph, "The accuracy of time-resolved methods is 30% of saturation..." should read "The accuracy of time resolved methods is 3% of saturation ..."

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A “NIRS” death experience: a reduction in cortical oxygenation by time-resolved near-infrared spectroscopy preceding cardiac arrest

Journal of Clinical Monitoring and Computing ◽

10.1007/s10877-017-0061-8 ◽

2017 ◽

Vol 32 (4) ◽

pp. 683-686 ◽

Cited By ~ 2

Author(s):

C. Lanks ◽

C. B. Kim ◽

H. B. Rossiter

Keyword(s):

Cardiac Arrest ◽

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Time Resolved ◽

Death Experience ◽

Cortical Oxygenation

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Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets

Journal of Applied Physiology ◽

10.1152/japplphysiol.00830.2005 ◽

2006 ◽

Vol 100 (3) ◽

pp. 850-857 ◽

Cited By ~ 31

Author(s):

Kenneth M. Tichauer ◽

Derek W. Brown ◽

Jennifer Hadway ◽

Ting-Yim Lee ◽

Keith St. Lawrence

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Neonatal Intensive Care ◽

Near Infrared ◽

Hemoglobin Concentration ◽

Oxygen Extraction Fraction ◽

Newborn Piglets ◽

Hypoxia Ischemia

Impaired oxidative metabolism following hypoxia-ischemia (HI) is believed to be an early indicator of delayed brain injury. The cerebral metabolic rate of oxygen (CMRO2) can be measured by combining near-infrared spectroscopy (NIRS) measurements of cerebral blood flow (CBF) and cerebral deoxy-hemoglobin concentration. The ability of NIRS to measure changes in CMRO2 following HI was investigated in newborn piglets. Nine piglets were subjected to 30 min of HI by occluding both carotid arteries and reducing the fraction of inspired oxygen to 8%. An additional nine piglets served as sham-operated controls. Measurements of CBF, oxygen extraction fraction (OEF), and CMRO2 were obtained at baseline and at 6 h after the HI insult. Of the three parameters, only CMRO2 showed a persistent and significant change after HI. Five minutes after reoxygenation, there was a 28 ± 12% (mean ± SE) decrease in CMRO2, a 72 ± 50% increase in CBF, and a 56 ± 19% decrease in OEF compared with baseline ( P < 0.05). By 30 min postinsult and for the remainder of the study, there were no significant differences in CBF and OEF between control and insult groups, whereas CMRO2 remained depressed throughout the 6-h postinsult period. This study demonstrates that NIRS can measure decreases in CMRO2 caused by HI. The results highlight the potential for NIRS to be used in the neonatal intensive care unit to detect delayed brain damage.

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