Hormonal Treatment and Cardiovascular Risk Profile in Transgender Adolescents

2021 ◽  
pp. 64-72
Author(s):  
Maartje Klaver ◽  
Renée de Mutsert ◽  
Maria A.T.C. van der Loos ◽  
Chantal M. Wiepjes ◽  
Jos W.R. Twisk ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Hormonal Treatment ◽  
Risk Profile ◽  
Model Assessment ◽  
Obesity Prevalence ◽  
Cardiovascular Risk Profile ◽  
Homeostatic Model Assessment ◽  
Prevalence Of Obesity ◽  
Subsequent Addition

BACKGROUND AND OBJECTIVES The effects of endocrinological treatment on cardiovascular risk profile in transgender adolescents are unknown. In this retrospective cohort study, we aim to investigate these effects and assess obesity and dyslipidemia prevalence in transgender adolescents at 22 years compared with peers. METHODS Changes in BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, homeostatic model assessment for insulin resistance (HOMA-IR), and lipid values during treatment, along with the prevalence of obesity and dyslipidemia at 22 years, were recorded in 71 transwomen and 121 transmen who started gonadotropin-releasing hormone agonists in their adolescence (15 years), with a subsequent addition of sex hormones (17 years). RESULTS In transwomen, changes in BMI (+3.0; 95% confidence interval [CI] 1.6 to 4.4), SBP (–2 mmHg; 95% CI –7 to 3), DBP (+10 mmHg; 95% CI 7 to 14), glucose (0.0 mmol/L; 95% CI –0.2 to 0.2), HOMA-IR (+0.6; 95% CI –0.6 to 1.9), and lipid values were similar or more favorable compared with peers. The same was true for transmen regarding changes in BMI (+2.3; 95% CI 1.7 to 2.9), SBP (+7 mmHg; 95% CI 3 to 10), DBP (+7 mmHg; 95% CI 5 to 10), glucose (+0.1 mmol/L; 95% CI –0.1 to 0.3), HOMA-IR (–0.2; 95% CI –0.8 to 0.3), and lipid values. At age 22, obesity prevalence was 9.9% in transwomen, 6.6% in transmen, 2.2% in ciswomen, and 3.0% in cismen. CONCLUSIONS Generally, endocrinological treatment in transgender adolescents is safe regarding cardiovascular risk. Because obesity is more prevalent in transgender adolescents compared with peers, body weight management should be important during the medical trajectory.

scholarly journals Impact of the COVID‑19 pandemic on blood pressure control and cardiovascular risk profile in patients with hypertension

2021 ◽  
Vol 131 (10) ◽  
Author(s):  
Andrzej Januszewicz ◽  
Wiktoria Wojciechowska ◽  
Aleksander Prejbisz ◽  
Piotr Dobrowolski ◽  
Marek Rajzer ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Risk Profile ◽  
Cardiovascular Risk Profile

scholarly journals Hormonal treatment and cardiovascular risk profile in transgender adolescents

2020 ◽  
Author(s):  
Klaver M ◽  
de Mutsert R ◽  
van der Loos M ◽  
Wiepjes CM ◽  
Twisk JWR ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Hormonal Treatment ◽  
Risk Profile ◽  
Cardiovascular Risk Profile

scholarly journals Hormonal Treatment and Cardiovascular Risk Profile in Transgender Adolescents

PEDIATRICS ◽  
2020 ◽  
Vol 145 (3) ◽  
pp. e20190741 ◽  
Author(s):  
Maartje Klaver ◽  
Renée de Mutsert ◽  
Maria A.T.C. van der Loos ◽  
Chantal M. Wiepjes ◽  
Jos W.R. Twisk ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Hormonal Treatment ◽  
Risk Profile ◽  
Cardiovascular Risk Profile

scholarly journals Framingham Risk Stratification of Middle-Aged Migraineurs

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Gyula Bank ◽  
Krisztian Kapus ◽  
Janos Meszaros ◽  
Kornel Mak ◽  
Marietta Pohl ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
High Risk ◽  
Migraine With Aura ◽  
Risk Profile ◽  
Cardiovascular Risk Profile ◽  
Middle Aged ◽  
Moderate Risk ◽  
Diabetes Status ◽  
Very High

Introduction. Migraine is a common primary headache disorder involving about 10-15% of the whole population. Several epidemiological and prospective studies showed a link between migraine (especially migraine with aura) and cardio- and cerebrovascular events. Objectives. We prospectively analyzed the data of vascular event-free middle-aged patients with migraine who were referred to our Headache Clinic between 01/2014 and 01/2018. Framingham 10-year risk were calculated; covariates included in the analysis were age, total cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication use, current smoking, and diabetes status. Results. Total of 1037 patients were screened and 221 were selected, 161 were women (mean age 55.5±5.2 years) and 60 were men (mean age 56±6 years). 25 patients (11.3%) were labelled as having low risk, 162 patients (73.3%) had moderate risk, and 34 patients (15.4%) had high or very high risk. Blood pressure and lipid targets were reached in 73% and in 49% in the moderate risk and in 53% and 12% in the high risk/very high risk groups, respectively. Migraine with aura (MA) was associated significantly higher cardiovascular risk profile compared with migraine without aura (MO). About one-third of our nondiabetic patients had fasting blood glucose above the normal levels. 24 patients (mean age 60±4.9 years) were diabetic. Mean blood pressure was 149/85 Hgmm, mean choleterol was 5.11 mmol/l, and mean LDL was 2.93 mmol/l in this subgroup, respectively, which do not fall within the recommended targets. Conclusion. Our article draws attention to the higher cardiovascular risk profile of middle-aged migraineurs and highlights the deficiency of primary prevention. Pain physicians must be aware of the cardiovascular aspects of migraine and holistic approach is required instead of focusing only on pain and pain relief.

Sign in / Sign up

Export Citation Format

Share Document