Letter To The Editor

Dr. Liebman writes as follows: Dr. Guntheroth's excellent comments are worth noting. Obviously, there are no data from our paper or anybody else's that give evidence that the renin-angiotensin system did not begin the chain of events ending in hypertension. Furthermore, the control theory-feedback mechanism concept for hypertension as expressed by Dr. Guyton indicate that renin levels should be normal at this time. However, other than the fact that it makes sense that the renin-angiotensin system started it all, what evidence is there that it did indeed start it all.

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Letter to the Editor: Brain renin–angiotensin system and liver-directed siRNA targeted to angiotensinogen

Clinical Science ◽

10.1042/cs20210163 ◽

2021 ◽

Vol 135 (7) ◽

pp. 907-910

Author(s):

Carlos M. Ferrario ◽

Leanne Groban ◽

Hao Wang ◽

Sarfaraz Ahmad

Keyword(s):

Renin Angiotensin System ◽

Angiotensin System ◽

Renin Angiotensin ◽

Letter To The Editor

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Reply to Letter to the Editor: “Don’t judge too RAShly: the multifaceted role of the renin-angiotensin system and its therapeutic potential in COVID-19”

AJP Lung Cellular and Molecular Physiology ◽

10.1152/ajplung.00133.2020 ◽

2020 ◽

Vol 318 (5) ◽

pp. L1029-L1030

Author(s):

Zaid A. Abassi ◽

Karl Skorecki ◽

Samuel N. Heyman ◽

Safa Kinaneh ◽

Zaher Armaly

Keyword(s):

Therapeutic Potential ◽

Renin Angiotensin System ◽

Angiotensin System ◽

Renin Angiotensin ◽

Letter To The Editor

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Letter to the Editor: “Insulin Resistance, the Renin-Angiotensin System, and Associated Renal Injury: Is Insulin Resistance the Culprit?”

Renal Failure ◽

10.1080/08860220601039536 ◽

2007 ◽

Vol 29 (1) ◽

pp. 113-114

Author(s):

Mohamed H. Ahmed

Keyword(s):

Insulin Resistance ◽

Renal Injury ◽

Renin Angiotensin System ◽

Angiotensin System ◽

Renin Angiotensin ◽

Letter To The Editor

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Novel expression and regulation of the renin-angiotensin system in metanephric organ culture

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.2000.279.2.r522 ◽

2000 ◽

Vol 279 (2) ◽

pp. R522-R530 ◽

Cited By ~ 13

Author(s):

Victoria F. Norwood ◽

Marjorie Garmey ◽

Jeffrey Wolford ◽

Robert M. Carey ◽

R. Ariel Gomez

Keyword(s):

Organ Culture ◽

Renin Angiotensin System ◽

Feedback Mechanism ◽

Renin Activity ◽

Ang Ii ◽

Isolated Cells ◽

Angiotensin System ◽

Renin Angiotensin ◽

Renin Mrna ◽

Positive Feedback Mechanism

To evaluate the presence and regulation of the renin-angiotensin system (RAS) in metanephric organ culture, embryonic day 14 (E14) rat metanephroi were cultured for 6 days. mRNAs for renin and both ANG II receptors (AT1 and AT2) are expressed at E14, and all three genes continue to be expressed in culture. Renin mRNA is localized to developing tubules and ureteral branches in the cultured explants. At E14, renin immunostaining is found in isolated cells scattered within the mesenchyme. As differentiation progresses, renin localizes to the ureteric epithelium, developing tubules and glomeruli. E14 metanephroi contain ANG II, and peptide production persists in culture. Renin activity is present at E14 (6.13 ± 0.61 pg ANG I · kidney−1 · h−1) and in cultured explants (28.84 ± 1.13 pg ANG I · kidney−1 · h−1). Renin activity in explants is increased by ANG II treatment (70.1 ± 6.36 vs. 40.97 ± 1.94 pg ANG I · kidney−1 · h−1 in control). This increase is prevented by AT1 blockade, whereas AT2 antagonism has no effect. These studies document an operational local RAS and a previously undescribed positive-feedback mechanism for renin generation in avascular, cultured developing metanephroi. This novel expression pattern and regulatory mechanism highlight the unique ability of developing renal cells to express an active RAS.

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