Prevention and Therapy of Serous Otitis Media by Oral Decongestant: A Double-Blind Study in Pediatric Practice

PEDIATRICS ◽  
1978 ◽  
Vol 61 (5) ◽  
pp. 679-684 ◽  
Author(s):  
Ardis L. Olson ◽  
Suzanne W. Klein ◽  
Evan Charney ◽  
James B. MacWhinney ◽  
Thomas K. McInerny ◽  
...  
Keyword(s):  
Otitis Media ◽  
Clinical Evaluation ◽  
Acute Otitis Media ◽  
Blind Study ◽  
Double Blind Study ◽  
Pediatric Practice ◽  
Double Blind ◽  
Treatment Groups ◽  
Serous Otitis Media ◽  
Prevention And Therapy

We studied the efficacy of (1) preventing the development of serous otitis media (SOM) by using an oral decongestant in children with acute otitis media and (2) treating SOM with an oral decongestant. In a randomized double-blind study, 190 children were treated for acute otitis media with antibiotics and either pseudoephedrine hydrochloride (Sudafed) or placebo. They were evaluated two weeks later by tympanometry and (independently) by clinical evaluation and pneumotoscopy. There were no significant differences between the two groups, except that males developed SOM significantly more often than did females. Use of decongestant and placebo was continued in 78 patients with SOM for up to four more weeks. Again, there were no significant differences between the treatment groups except that patients with an allergic history did significantly worse using a decongestant. Overall there was no benefit from pseudoephedrine in either the prevention or treatment of SOM.

A Comparative Clinical Trial of Diflunisal and Ibuprofen in the Control of Pain in Osteoarthritis

1979 ◽  
Vol 7 (4) ◽  
pp. 272-276 ◽  
Author(s):  
J G M Keet
Keyword(s):  
Clinical Trial ◽  
Blind Study ◽  
Double Blind Study ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Comparative Clinical Trial ◽  
Treatment Groups ◽  
Ambulatory Patients ◽  
Efficacy Parameters ◽  
Osteoarthritis Of Hip

A randomized double-blind study in ambulatory patients with osteoarthritis of hip and/or knee was conducted, comparing the efficacy and safety of diflunisal 500 mg daily with ibuprofen 1200 mg daily, over a period of 8 weeks. Thirty-five patients participated in the study. The results revealed no significant differences between the treatment groups with regard to the efficacy parameters.

Spectrophotometric Otoscope: A New Tool in the Diagnosis of Otitis Media

2007 ◽  
Vol 15 (4) ◽  
pp. 209-215 ◽  
Author(s):  
Zeev Schmilovitch ◽  
Victor Alchanatis ◽  
Menashe Shachar ◽  
Yehud Holdstein
Keyword(s):  
Primary Care ◽  
Otitis Media ◽  
Primary Care Physicians ◽  
Acute Otitis Media ◽  
Care Physician ◽  
Public Healthcare ◽  
Least Squares Regression ◽  
Double Blind ◽  
Diagnostic Aid ◽  
Serous Otitis Media

Otitis media is one of the most common childhood ailments and, therefore, has a significant impact on public healthcare expenditure. The initial diagnosis is usually performed by a primary-care physician and is based upon otoscopy and symptomatology; the certainty of diagnosis of acute otitis media is only 58–73%. This study aimed to assess the efficacy of a spectrophotometer-based system in identifying otitis media by comparing the output from the system with the clinical diagnosis of an experienced otologist and, hence, to evaluate the system as a diagnostic aid to primary-care physicians. The study was prospective and double blind. An otologist examined 258 patients consecutively with an oto-microscope and all of the patients were simultaneously examined with a spectrometer-based data acquisition system incorporated in a standard otoscope. The otologist's diagnosis served as a “gold standard”. The acquired data were analysed by means of partial least squares regression. The system correctly differentiated acute otitis media from serous otitis media and normal ears with sensitivity of 93% and specificity of 88%. The sensitivity and specificity were 89 and 95%, respectively, in a subset of subjects aged 12 y or less. Spectrophotometry was found to be a highly accurate means of diagnosing acute otitis media. We consider that it will become an important diagnostic aid for primary care physicians.

Cyclacillin Versus Amoxicillin as Treatment for Acute Otitis Media

PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 196-199
Author(s):  
Samuel E. McLinn ◽  
Steven Serlin
Keyword(s):  
Otitis Media ◽  
Clinical Success ◽  
Acute Otitis Media ◽  
Double Blind Study ◽  
Cure Rate ◽  
Double Blind ◽  
Resistant Strains ◽  
Low Incidence ◽  
Pediatric Outpatients ◽  
Upper Gastrointestinal

A double-blind study of 240 pediatric outpatients with acute otitis media demonstrated that cyclacillin administered three times a day for ten days, is as effective as and better tolerated than a similar regimen of amoxicillin. Clinical success was achieved in 96% of the children treated with each drug, and the bacteriologic cure rate was 98% in each treatment group. Only three of the 119 children (2.5%) treated with cyclacillin had drug-related diarrhea, in contrast to 17/121 children (14%) treated with amoxicllin (P <.01). This greater tolerance for cyclacillin may be due to its more effective and rapid absorption in the upper gastrointestinal tract. The results are discussed in terms of the low incidence of resistant strains of Haemophilus influenzae and the advantages of cyclacillin as the first-line treatment for acute otitis media.

scholarly journals Clinical evaluation of Emorfazone for dento-oral inflammatory diseases - A comparative double blind study with aspirin.

1986 ◽  
Vol 32 (12) ◽  
pp. 2443-2460
Author(s):  
Masanobu OHNISHI ◽  
Tsuyoshi KAWAI ◽  
Yoshiyuki HATTORI ◽  
Shigeru YOSHIDA ◽  
Takanori HATTORI ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Inflammatory Diseases ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind
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