Successful Treatment of Juvenile Chronic Granulocytic Leukemia With Marrow Transplantation

PEDIATRICS ◽  
1979 ◽  
Vol 63 (1) ◽  
pp. 44-46
Author(s):  
Jean E. Sanders ◽  
C. Dean Buckner ◽  
Patricia Stewart ◽  
E. Donnall Thomas
Keyword(s):  
Bone Marrow ◽  
Maintenance Therapy ◽  
Total Body Irradiation ◽  
Marrow Transplantation ◽  
Marrow Transplant ◽  
Successful Outcome ◽  
Chronic Granulocytic Leukemia ◽  
Total Body ◽  
Granulocytic Leukemia ◽  
Disease Free

A 46-month-old boy with juvenile chronic granulocytic leukemia was treated intensively with hydroxyurea dimethyl myleran, cyclophosphamide, and total body irradiation. He then received a marrow transplant from an HL-A matched brother. Thirty-two months after the transplantation, he is hematologically normal and remains disease free on no-maintenance therapy. The successful outcome of this case suggests that a bone marrow transplant for any patient with a suitable histocompatible donor should be considered in the treatment of this disease.

Intensive chemotherapy, total body irradiation, and autologous marrow transplantation for chronic granulocytic leukemia-blast phase: report of four additional cases.

1984 ◽  
Vol 2 (5) ◽  
pp. 379-384 ◽  
Author(s):  
G L Phillips ◽  
G P Herzig
Keyword(s):  
Total Body Irradiation ◽  
Marrow Transplantation ◽  
Philadelphia Chromosome ◽  
Stable Phase ◽  
Intensive Chemotherapy ◽  
Blast Phase ◽  
Interesting Phenomenon ◽  
Chronic Granulocytic Leukemia ◽  
Total Body ◽  
Granulocytic Leukemia

Four patients with Philadelphia chromosome (Ph1)-positive chronic granulocytic leukemia (CGL) in blast phase received cyclophosphamide, total body irradiation, and autologous marrow transplants using cryopreserved marrow from the stable phase. Two patients fully reestablished stable-phase leukemia that lasted for 26 and six months; the first patient developed transient Ph1-negative hematopoiesis after transplantation. Three patients eventually died of recurrent blast-phase leukemia. Previous studies using autologous marrow for CGL have reported an occasional long survivor, but incomplete engraftment and especially the rapid recurrence of blast-phase leukemia have been responsible for the overall poor results. The latter problem complicates even normal marrow transplantation, indicating the inadequacy of the current therapeutic regimens used for treating blast-phase leukemia and the possibility of improving results with more effective regimens and autologous marrow transplantation. Although it is unknown whether the reestablishment of Ph1-negative hematopoiesis after transplantation contributes to improved survival, this interesting phenomenon must be investigated further.

scholarly journals Marrow transplantation for children with acute lymphoblastic leukemia in second remission

Blood ◽  
1987 ◽  
Vol 70 (1) ◽  
pp. 324-326 ◽  
Author(s):  
JE Sanders ◽  
ED Thomas ◽  
CD Buckner ◽  
K Doney
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Total Body Irradiation ◽  
Marrow Transplantation ◽  
Lymphoblastic Leukemia ◽  
Disease Free Survival ◽  
Bone Marrow Transplants ◽  
Free Survival ◽  
Total Body ◽  
Disease Free

Fifty-seven children between the ages of 3 and 17 years with acute lymphoblastic leukemia (ALL) in chemotherapy-induced second bone marrow remission were given cyclophosphamide, total body irradiation, and bone marrow transplants from HLA-matched donors. Sixteen died of transplant- related complications. Eighteen relapsed between 56 and 833 days after transplantation, and 16 died of leukemia. Two survive in remission off treatment following chemotherapy. Twenty-three survive in continuous remission from 1.4 to 10.4 years after transplantation and the actuarial analysis shows disease-free survival of 40% with a plateau extending from 2.5 to 10.4 years.

scholarly journals Marrow transplantation for children with acute lymphoblastic leukemia in second remission

Blood ◽  
1987 ◽  
Vol 70 (1) ◽  
pp. 324-326 ◽  
Author(s):  
JE Sanders ◽  
ED Thomas ◽  
CD Buckner ◽  
K Doney
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Total Body Irradiation ◽  
Marrow Transplantation ◽  
Lymphoblastic Leukemia ◽  
Disease Free Survival ◽  
Bone Marrow Transplants ◽  
Free Survival ◽  
Total Body ◽  
Disease Free

Abstract Fifty-seven children between the ages of 3 and 17 years with acute lymphoblastic leukemia (ALL) in chemotherapy-induced second bone marrow remission were given cyclophosphamide, total body irradiation, and bone marrow transplants from HLA-matched donors. Sixteen died of transplant- related complications. Eighteen relapsed between 56 and 833 days after transplantation, and 16 died of leukemia. Two survive in remission off treatment following chemotherapy. Twenty-three survive in continuous remission from 1.4 to 10.4 years after transplantation and the actuarial analysis shows disease-free survival of 40% with a plateau extending from 2.5 to 10.4 years.

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