The Association of Inflammatory Bowel Disease and X Chromosomal Abnormality

PEDIATRICS ◽  
1980 ◽  
Vol 66 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Karunyan Arulanantham ◽  
Michael S. Kramer ◽  
Joyce D. Gryboski
Keyword(s):  
Inflammatory Bowel Disease ◽  
Turner Syndrome ◽  
Bowel Disease ◽  
Chromosomal Abnormality ◽  
Growth Failure ◽  
Clinical Importance ◽  
Immune Mechanism ◽  
Pure Chance ◽  
Inflammatory Bowel ◽  
Referral Bias

Five patients with inflammatory bowel disease (IBD) had abnormalities of the X chromosome (the Turner syndrome). Based on the estimated prevalence rate of 1:10,000 live female births for the Turner syndrome and 1:50,000 for IBD, random association of these two conditions would be expected in 1:500 million live female births. Given these odds, the findings in these five patients would suggest a clinical association not based on pure chance and unlikely to be accounted for by Berkson's or other referral bias. It is speculated that abnormal immune mechanism could possibly increase the susceptibility of patients with the Turner syndrome to develop IBD. Both conditions cause growth failure. Awareness of the association has clinical importance in identifying the cause of growth failure in a child with either X chromosomal abnormality or IBD.

scholarly journals Growth failure is rare in a contemporary cohort of paediatric inflammatory bowel disease patients

2020 ◽  
Vol 110 (1) ◽  
pp. 326-334
Author(s):  
James J. Ashton ◽  
Zachary Green ◽  
Aneurin Young ◽  
Florina Borca ◽  
Tracy Coelho ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Growth Failure ◽  
Inflammatory Bowel

Growth Failure and Pediatric Inflammatory Bowel Disease

2013 ◽  
pp. 105-108
Author(s):  
Marina Aloi ◽  
Salvatore Cucchiara ◽  
Milvia Martino ◽  
Richard C. Semelka ◽  
Ernesto Tomei
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Growth Failure ◽  
Pediatric Inflammatory Bowel Disease ◽  
Inflammatory Bowel

Guidelines for the management of growth failure in childhood inflammatory bowel disease

2008 ◽  
Vol 14 (6) ◽  
pp. 839-849 ◽  
Author(s):  
Robert Heuschkel ◽  
Camilla Salvestrini ◽  
Mark R. Beattie ◽  
Hans Hildebrand ◽  
Thomas Walters ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Growth Failure ◽  
Inflammatory Bowel

Turner Syndrome and Inflammatory Bowel Disease

1976 ◽  
Vol 294 (22) ◽  
pp. 1221-1222 ◽  
Author(s):  
Ilja J. Weinrieb ◽  
Robert M. Fineman ◽  
Howard M. Spiro
Keyword(s):  
Inflammatory Bowel Disease ◽  
Turner Syndrome ◽  
Bowel Disease ◽  
Inflammatory Bowel

Ulcerative Colitis and Crohn Disease in Children

1987 ◽  
Vol 9 (4) ◽  
pp. 109-120
Author(s):  
Kathleen J. Motil ◽  
Richard J. Grand
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn Disease ◽  
Bowel Disease ◽  
Correct Diagnosis ◽  
Age Groups ◽  
Growth Failure ◽  
Clinical Findings ◽  
Chronic Inflammatory Bowel Disease ◽  
Inflammatory Bowel

Once considered rare in pediatric practice, chronic inflammatory bowel disease is now recognized with increasing frequency in children. Ulceractive colitis and Crohn disease constitute the two major entities, and it is still not clear whether these are two separate entities or different portions of the spectrum of one disease. Abdominal pain, diarrhea, rectal bleeding, weight loss, and anemia are prominent findings in both ulcerative colitis and Crohn disease; however, extraintestinal manifestations may dominate the clinical findings, masquerading as juvenile rheumatoid arthritis, idiopathic growth failure, or even anorexia nervosa. Often, it is not until intestinal manifestations are recognized that a correct diagnosis is made.1 EPIDEMIOLOGY OF INFLAMMATORY BOWEL DISEASE Since 1950, there has been an increase, in the incidence of Crohn disease, ranging from 100% to 400% in all age groups.2 In contrast, the incidence of ulcerative colitis has not changed significantly. Ulcerative colitis is diagnosed in 15% of patients before the age of 20 years, usually in adolescence. Although ulcerative colitis may occur in infancy, inflammatory disease of the colon during the first year of life is more often due to food allergy3 or infectious disease. Certain groups of children are at greater risk for the development of inflammatory bowel disease. Ulcerative colitis and Crohn disease occur more commonly among Northern European, Anglo-Saxon races, in urban rather than rural dwellers, and in Jewish individuals living in Europe and North America.

scholarly journals Treatment of Inflammatory Bowel Disease in Children

1990 ◽  
Vol 4 (7) ◽  
pp. 404-406 ◽  
Author(s):  
D Grant Gall
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Bowel Disease ◽  
Growth Failure ◽  
Nutritional Therapy ◽  
Inflammatory Bowel

As no curative therapy exists, supportive measures play an important role in the management of patients with inflammatory bowel disease (IBO). Aminosalicylic acid (ASA) compounds and corticosteroids remain the mainstay of medical therapy. Aminosalicylates are recommended for therapy of mild to moderate active ulcerative colitis and for the maintenance of remission in ulcerative colitis. The role of 5-ASA preparations in Crohn's disease is less clear. In granulomatous colitis, 5-ASA therapy is recommended. With the development of new delivery systems, the role for 5-ASA in the treatment of small bowel Crohn's disease is under investigation. Prednisone remains the drug of choice in severe ulcerative colitis and active Crohn's disease. The role of immunosuppressive drugs in pediatric patients is unclear. Nutritional therapy has been an important advance in the treatment of children with Crohn's disease, especially those with growth failure. Nutritional therapy can consist of combined total parenteral and enteral nutrition or enteral nutrition alone. An initial period of total parenteral nutrition followed by a six to eight week course of enteral therapy with a semisynthetic diet has been shown to be effective in the management of patients with severe active disease and growth failure.

scholarly journals COVID-19 and Inflammatory Bowel Disease: Patient Knowledge and Perceptions in a Single Center Survey

Medicina ◽  
2020 ◽  
Vol 56 (8) ◽  
pp. 407
Author(s):  
Rocco Spagnuolo ◽  
Tiziana Larussa ◽  
Chiara Iannelli ◽  
Cristina Cosco ◽  
Eleonora Nisticò ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Clinical Importance ◽  
Educational Material ◽  
Older Age ◽  
Prevention Measures ◽  
High Knowledge ◽  
Inflammatory Bowel ◽  
High Level ◽  
Active Disease

Background and objectives: Spreading of SARS-CoV-2 infection from China to countries with a higher prevalence of inflammatory bowel disease (IBD) has generated concern among gastroenterologists and patients. The aim of this survey is to evaluate knowledge about clinical importance of COVID-19, disease management, prevention measures, and anxiety level during pandemic among patients with IBD. Material and methods: From 15th March to 15th April 2020, a questionnaire survey was administered to 200 patients with IBD by email or phone application. The questionnaire consisted of five sections: (1) anthropometric, demographic and clinical characteristics, (2) knowledge about clinical importance of COVID-19, (3) IBD management, (4) prevention measures, (5) anxiety level during pandemic. Results: One hundred forty two questionnaires were completed. Ninety-seven patients (68.3%) were males with a mean age of 46 years (SD 13; range 17–76). Fifty-four individuals (38%) were affected by Crohn disease and 88 (62%) by Ulcerative Colitis. Most patients reported high knowledge about clinical importance of COVID-19 (80%), IBD management (72%), and prevention measures (97%). Sixty-two percent of them showed moderate-high level of anxiety. High education level was independently associated with high knowledge about clinical importance of COVID-19 (odds ratio [OR] 5, 95% confidence interval [CI] 1.49–16.6, p = 0.009) and older age (OR 1, 95%, CI 1.01–1.1, p = 0.01), while the receipt of e-format educational material with low knowledge about clinical importance of COVID-19 (OR 3, 95%, CI 1.08–9.3, p = 0.03). Displaying an active disease appeared to be independently associated with low knowledge of IBD management (OR 5.8, 95% CI 1.4–22.8, p = 0.01) and no variables other than an older age was independently associated with higher level of anxiety (OR 1.04, 95% CI 1.009–1.09, p = 0.01). Conclusions: High educational level and aging promote knowledge about clinical importance of COVID-19, while e-format educational material does not. Taken together with findings that an active disease status compromises knowledge of IBD management and the high level of anxiety related to increasing age, these data suggest the need of further supporting patient-oriented strategies in IBD during Covid-19 pandemic.

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