High-Density Lipoprotein-Cholesterol Subfractions in Adolescent Twins

PEDIATRICS ◽  
1987 ◽  
Vol 79 (2) ◽  
pp. 181-189
Author(s):  
Joann N. Bodurtha ◽  
Richard Schieken ◽  
Jere Segrest ◽  
Walter E. Nance
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Cardiovascular Death ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Increased Risk ◽  
History Of ◽  
High Level ◽  
Adolescent Twins

Data on the levels of high-density lipoprotein-cholesterol (HDL-C) and subfractions in 102 adolescent twin pairs and their parents are presented. Children with a family history of premature cardiovascular death had lower levels of HDL2-C than did those without such a history. White girls reporting a high level of physical activity had higher levels of HDL-C and HDL2-C than did their more sedentary peers. In general, children of mothers who smoked had lower HDL2-C than did children of nonsmoking mothers. These findings suggest that low levels of HDL2-C in children may identify families in which there is an increased risk of coronary heart disease and that parental smoking may contribute to changes in this risk factor in the children of smokers as well as in the smokers themselves.

scholarly journals Association between the Non-high-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio and the Risk of Coronary Artery Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jiayin You ◽  
Zhenhao Wang ◽  
Guoping Lu ◽  
Zhenyue Chen
Keyword(s):  
Coronary Artery Disease ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Gensini Score ◽  
Coronary Syndrome ◽  
Increased Risk ◽  
Artery Disease

Background. The purpose of this study was to evaluate the association between the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non-HDL-C/HDL-C in the prognosis of CAD. Methods. We analyzed 930 consecutive patients with chest discomfort who underwent coronary angiography. Of these, 680 were diagnosed with CAD; the remaining 250 patients were normal. Multivariate logistic regression and receiver operating characteristic (ROC) curves were employed to evaluate the association between non-HDL-C/HDL-C and CAD. The effect of non-HDL-C/HDL-C on the progression of major adverse cardiovascular events (MACEs) was also explored. Results. Increased non-HDL-C/HDL-C was associated with an increased risk of CAD (OR: 1.291; 95% CI: 1.039-1.561; P=0.013). The results of stratified analyses by CAD subtype showed a correlation between high non-HDL-C/HDL-C and increased risk of acute coronary syndrome (OR: 1.661; 95% CI: 1.259-2.207; P<0.001), high Gensini score (OR: 1.408; 95% CI: 1.021-1.935; P=0.039), and multivessel disease (OR: 1.487; 95% CI: 1.128-1.992; P=0.007). Moreover, the areas under the ROC for the predictive value of non-HDL-C/HDL-C for CAD, acute coronary syndrome, high Gensini score, and multivessel disease were 0.604, 0.658, 0.642, and 0.636, respectively. Non-HDL-C/HDL-C in CAD patients was significantly correlated with the risk of long-term MACEs (P=0.004). Conclusions. The findings of this study indicated that non-HDL-C/HDL-C plays an important role in the risk and progression of CAD. These findings need verification by further large-scale prospective studies.

scholarly journals SP671ASSOCIATION OF HIGH LEVEL OF FERRITIN WITH HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN PATIENTS UNDER HEMODIALYSIS

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii364-iii364
Author(s):  
Misa Ikeda ◽  
Hirokazu Honda ◽  
Keiko Takahashi ◽  
Kanji Shishido ◽  
Takanori Shibata
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
High Level

scholarly journals Positive association between plasma IGF1 and high-density lipoprotein cholesterol levels in adult nondiabetic subjects

2010 ◽  
Vol 163 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Elena Succurro ◽  
Franco Arturi ◽  
Alessandro Grembiale ◽  
Fiorella Iorio ◽  
Irma Laino ◽  
...  
Keyword(s):  
Waist Circumference ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Model Assessment ◽  
Increased Risk ◽  
Low Hdl

AimsLow IGF1 levels have been associated with an increased cardiovascular risk. It is unknown however whether IGF1 mediates the atherosclerotic process by modulating high-density lipoprotein cholesterol (HDL-C) independently from confounders. To address this issue, we evaluated the association between IGF1 levels and HDL-C in nondiabetic subjects.MethodsA cross-sectional analysis was used in the context of the CAtanzaro MEtabolic RIsk factors Study. One thousand and four participants (aged 20–69 years), for whom HDL-C and IGF1 measurements were available, were eligible for the study.ResultsAfter adjusting for gender and age, IGF1 levels were positively correlated with HDL-C, and negatively correlated with body mass index (BMI), waist circumference, blood pressure (BP), triglyceride, fasting insulin, and homeostasis model assessment (HOMA). In a logistic regression model adjusted for age and gender, IGF1 in the lowest tertile (<125 ng/ml) was associated with an increased risk of having low HDL-C (odds ratio (OR) 2.14, 95% confidence interval (CI) 1.4–3.0; P=4×10−5) compared with the highest tertile (>186 ng/ml). When BMI, waist circumference, total cholesterol, triglyceride, and HOMA index were added to the model, IGF1 remained significantly associated with increased risk of low HDL-C (OR 1.52, 95% CI 1.01–2.31; P=0.04). A stepwise multivariate regression analysis in a model including age, gender, BMI, total cholesterol, triglycerides, IGF1, HOMA, and BP showed that the variables significantly associated with HDL-C were gender (P<0.0001), triglycerides (P<0.0001), total cholesterol (P<0.0001), BMI (P<0.0001), IGF1 levels (P<0.0001), and HOMA (P=0.001), accounting for 32.6% of its variation.ConclusionsThese data provide evidence that IGF1 may be an independent modulator for HDL-C in nondiabetic individuals.

scholarly journals Non-high-density Lipoprotein Cholesterol May Predict the Cardio-cerebrovascular Risk in Patients on Maintenance Hemodialysis

2021 ◽  
Author(s):  
Denggui Luo ◽  
Yueming Luo ◽  
Yanhong Zou ◽  
Yuanzhao Xu ◽  
Bo Fu ◽  
...  
Keyword(s):  
Risk Factor ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Area Under The Curve ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Youden Index ◽  
Maintenance Hemodialysis ◽  
Increased Risk

Abstract BackgroundNon-high-density lipoprotein cholesterol (non-HDL-C) may be an independent risk factor for cardio-cerebrovascular disease (CVD); however, the cutoff level in patients on maintenance hemodialysis (MHD) is unknown. MethodsWe performed a multicenter retrospective study of MHD patients treated at 10 dialysis centers in Guangdong Province from July 1, 2016, to April 1, 2017. We collected laboratory test data and recorded CVD complications and outcomes. ResultsA total of 1,288 patients were enrolled; the non-HDL-C interquartile range was 2.76 (2.24–3.45) mmol/L. Over a median follow-up time of 23 months, 142 patients developed CVD. The non-HDL-C level was a principal risk factor for such events (P < 0.05; area under the curve 0.822, 95% confidence interval 0.800–0.842). The maximum Youden index was 0.549 and the best cutoff > 3.39 mmol/L. ConclusionHigher baseline non-HDL-C levels are associated with an increased risk of CVD in MHD patients. Thus, non-HDL-C effectively predicts CVD.

COMPARITIVE STUDY OF HDL-C LEVEL IN DIABETIC AND NONDIABETIC STROKE SUBJECTS

1969 ◽  
Vol 6 (2) ◽  
pp. 816-820
Author(s):  
SAHIBZADA SAEED JAN ◽  
AMIN JAN ◽  
JAN.I.ALAM ◽  
TAJ MUHAMMAD KHAN
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Stroke Patients ◽  
History Of

BACKGROUND: Diabetes mellitus is a well recognized risk factor for acute stroke, resulting in agreater ischemic to hemorrhagic stroke ratio in the people with diabetes compared with the generalpopulation. Diabetes also doubles the risk of stroke recurrence and has a poor outcome (or having poorprognosis for survival) as compared to non-diabetic patients, warranting strong and comprehensivepreventive efforts, The aim of this study was to evaluate the High Density Lipoprotein-Cholesterol(HDL-C) level in the adult diabetic and non-diabetic stroke patients coming to Medical Unit of SaiduTeaching Hospital, Swat.MATERIAL AND METHODOLOGY: This was a cross-sectional study, comprised of 100 subjects,50 were diabetic and 50 were non -diabetic stroke patients of ages between 40 to 90 years. The studysubjects underwent a detailed history and examination. Individuals with a history of medications knownto affects body composition, patients on anti-coagulants and having a history of blood dyscrasias likeleukemia’s, thalasemia, polycythemia, endocrinopathies and patients having clotting disorders, extraduraland intradural hemorrhage as a cause of stroke were excluded from the study. Fasting as well as randomblood sample were drawn from the participants for biochemical assays. The serum HDL-C level, bloodsugar (random and fasting), blood pressure (systolic and diastolic) of Diabetic stroke subjects werecompared with Non-diabetic stroke subjects.RESULTS: The HDL-C level was significantly low in our study in diabetic as compared to nondiabetic stroke subjects.CONCLUSION: The low HDL-C level along with poor metabolic control is an important risk factorfor chronic complications of diabetes mellitus like microvascular and macrovascular disease likeunstable angina, myocardial infarction and stroke. Therefore there is intense need of early screening andinterventions, to prevent macrovascular complications especially stroke in high risk diabetic patients.KEY WORDS: Diabetes mellitus, High-density Lipoprotein-Cholesterol (HDL-C), Blood pressure,Stroke.

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