Management Strategies for Perinatal Hypoxic-Ischemic Encephalopathy

To the Editor.— The paper by Dr Vanucci1 (Pediatrics. June 1990) addresses an important issue in neonatal medicine [See table in the PDF file] namely the management of hypoxic-ischemic encephalopathy (HIE). The review is comprehensive and lucid, and the section on "new management strategies" comes at a time when considerable interest has been directed toward this form of therapy. HIE remains a major problem in developing countries where the incidence may be as high as 4% to 6% compared with about 0.2% to 0.9% in the developed world.1-3