scholarly journals Atrial Fibrosis, Ischaemic Stroke and Atrial Fibrillation

2021 ◽  
Vol 10 (4) ◽  
pp. 225-229
Author(s):  
Christian Mahnkopf ◽  
Younghoon Kwon ◽  
Nazem Akoum
Keyword(s):  
Atrial Fibrillation ◽  
Late Gadolinium Enhancement ◽  
Ischaemic Stroke ◽  
Recurrent Stroke ◽  
Future Research ◽  
Prevention Strategies ◽  
Atrial Fibrosis ◽  
Gadolinium Enhancement ◽  
Atrial Remodelling ◽  
New Onset

Atrial fibrosis is an important component of the arrhythmic substrate in AF. Evidence suggests that atrial fibrosis also plays a role in increasing the risk of stroke in patients with the arrhythmia. Patients with embolic stroke of undetermined source (ESUS), who are suspected to have AF but are rarely shown to have it, frequently demonstrate evidence of atrial fibrosis; measured using late-gadolinium enhancement MRI, this manifests as atrial remodelling encompassing structural, functional and electrical properties. In this review, the authors discuss the available evidence linking atrial disease, including fibrosis, with the risk of ischaemic stroke in AF, as well as in the ESUS population, in whom it has been linked to recurrent stroke and new-onset AF. They also discuss the implications of this association on future research that may elucidate the mechanism of stroke and stroke prevention strategies in the AF and ESUS populations.

scholarly journals Association of Electrocardiographic P-Wave Markers and Atrial Fibrillation in Embolic Stroke of Undetermined Source

2020 ◽  
pp. 1-8
Author(s):  
Tony Y.W. Li ◽  
Leonard Leong L. Yeo ◽  
Jamie Sin Ying Ho ◽  
Aloysius S. Leow ◽  
Mark Y. Chan ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Risk Stratification ◽  
Ischaemic Stroke ◽  
Recurrent Stroke ◽  
Embolic Stroke ◽  
P Wave ◽  
Stroke Recurrence ◽  
Atrial Remodeling ◽  
P Wave Dispersion ◽  
New Onset

<b><i>Background:</i></b> Several P-wave indices are thought to represent underlying atrial remodeling and have been associated with ischaemic stroke even in the absence of atrial fibrillation (AF). However, the utility of these P-wave indices in predicting outcomes in patients with embolic stroke of undetermined source (ESUS) has not been studied. The aim of this study is to examine these different P-wave indices towards predicting new-onset AF and stroke recurrence in a cohort of patients with ESUS, thereby demonstrating the value of these electrocardiographic markers for stroke risk stratification. <b><i>Methods:</i></b> Between October 2014 and October 2017, consecutive patients diagnosed with ESUS were followed for new-onset AF and ischaemic stroke recurrence. The various P-wave indices, namely, the P-terminal force in the precordial lead V1 (PTFV1), P-wave duration, P-wave dispersion, interatrial blocks, and P-wave axis, were assessed on the initial electrocardiogram on presentation and studied for their relation to eventual AF detection and recurrent stroke. <b><i>Results:</i></b> 181 ischaemic stroke patients with ESUS were recruited and followed up for a median duration of 2.1 years. An abnormal PTFV1 was associated with occult AF detection but not with recurrent ischaemic strokes. No significant association was observed between the other P-wave indices with either occult AF or stroke recurrence. <b><i>Conclusion:</i></b> PTFV1 is associated with AF detection but not recurrent strokes in ESUS patients and can be a useful electrocardiographic marker for further risk stratification in ESUS patients.

scholarly journals B-PO02-096 PREDICTION OF ATRIAL FIBRILLATION RECURRENCE POST-ABLATION BASED ON ATRIAL FIBROSIS BY LATE GADOLINIUM ENHANCEMENT: A META-ANALYSIS

Heart Rhythm ◽  
2021 ◽  
Vol 18 (8) ◽  
pp. S136
Author(s):  
Manjari Rani Regmi ◽  
Mukul Bhattarai Priyanka Parajuli ◽  
Albert Botchway Nitin Tandan ◽  
Jumana Abdelkarim ◽  
Mohamed Labedi
Keyword(s):  
Atrial Fibrillation ◽  
Late Gadolinium Enhancement ◽  
Meta Analysis ◽  
Atrial Fibrillation Recurrence ◽  
Atrial Fibrosis ◽  
Gadolinium Enhancement
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