SELECTION OF THE MATHEMATICAL MODEL FOR THE USE OF ENROFLOXACIN IN CATS

Author(s):  
Galya Shivacheva ◽  
Miroslav Vasilev

The process of changing the concentration of enrofloxacin in blood plasma in cats after single intravenous injection was identified by three mathematical models - algebraic and two models represented respectively by a first order differential equation and a second order differential equation. In order to select the best model of the three, the Akaike information criterion corrected is used. With the most identification parameters differs the model based on a second-order differential equation. The lowest value of the Akaike information criterion corrected was also obtained with it. This fact gives reason to choose it for the best model for describing the research process.

2019 ◽  
Vol 7 (4) ◽  
pp. 294-299
Author(s):  
Galya Shivacheva ◽  
Miroslav Vasilev

The process of changing the concentration of enrofloxacin in blood plasma in cats after single intravenous injection was identified by three mathematical models - algebraic and two models represented respectively by a first order differential equation and a second order differential equation. In order to select the best model of the three, the Akaike information criterion corrected is used. With the most identification parameters differs the model based on a second-order differential equation. The lowest value of the Akaike information criterion corrected was also obtained with it. This fact gives reason to choose it for the best model for describing the research process.


2019 ◽  
Vol 7 (2) ◽  
pp. 97-102 ◽  
Author(s):  
Miroslav Vasilev ◽  
Galya Shivacheva

This article analyzes the process of changing the concentration of enrofloxacin in blood plasma in dogs after a single intravenous injection of the substance. Three mathematical models are proposed - algebraic and two models, based on a differential equation of first and second order. Identification of their parameters has been performed. Based on Akaike information criterion corrected as the best model was chosen the represented by a second-order differential equation. Three equations are identified and the exact numerical values of their parameters are obtained. For the evaluation and comparison of the three models, Akaike information criterion was used. The best results showed the second-order differential model. It will be used in future developments.


1987 ◽  
Vol 35 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Renfrey B. Potts

The Weierstrass elliptic function satisfies a nonlinear first order and a nonlinear second order differential equation. It is shown that these differential equations can be discretized in such a way that the solutions of the resulting difference equations exactly coincide with the corresponding values of the elliptic function.


1993 ◽  
Vol 08 (21) ◽  
pp. 2037-2043 ◽  
Author(s):  
CHIHONG CHOU

Based on a simple observation that a classical second order differential equation may be decomposed into a set of two first order equations, we introduce a Hamiltonian framework to quantize the damped systems. In particular, we analyze the system of a linear damped harmonic oscillator and demonstrate that the time evolution of the Schrödinger equation is unambiguously determined.


1931 ◽  
Vol 27 (4) ◽  
pp. 546-552 ◽  
Author(s):  
E. C. Bullard ◽  
P. B. Moon

A mechanical method of integrating a second-order differential equation, with any boundary conditions, is described and its applications are discussed.


2018 ◽  
Vol 24 (2) ◽  
pp. 127-137
Author(s):  
Jaume Llibre ◽  
Ammar Makhlouf

Abstract We provide sufficient conditions for the existence of periodic solutions of the second-order differential equation with variable potentials {-(px^{\prime})^{\prime}(t)-r(t)p(t)x^{\prime}(t)+q(t)x(t)=f(t,x(t))} , where the functions {p(t)>0} , {q(t)} , {r(t)} and {f(t,x)} are {\mathcal{C}^{2}} and T-periodic in the variable t.


2017 ◽  
Vol 23 (2) ◽  
Author(s):  
Muhad H. Abregov ◽  
Vladimir Z. Kanchukoev ◽  
Maryana A. Shardanova

AbstractThis work is devoted to the numerical methods for solving the first-kind boundary value problem for a linear second-order differential equation with a deviating argument in minor terms. The sufficient conditions of the one-valued solvability are established, and the a priori estimate of the solution is obtained. For the numerical solution, the problem studied is reduced to the equivalent boundary value problem for an ordinary linear differential equation of fourth order, for which the finite-difference scheme of second-order approximation was built. The convergence of this scheme to the exact solution is shown under certain conditions of the solvability of the initial problem. To solve the finite-difference problem, the method of five-point marching of schemes is used.


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