Cerebral and peripheral muscle oxygenation and perfusion: Course in moderate and late preterm neonates during the first day after birth

AbstractAimTo investigate the ratio of cerebral tissue oxygenation index (cTOI) to peripheral muscle tissue oxygenation index (pTOI) measured by near-infrared spectroscopy (NIRS) in cardio-circulatory stable preterm neonates without signs of inflammation/infection on the first day after birth.MethodsObservational study analysing secondary outcome parameters of the ‘Avoiding Hypotension in Preterm Neonates (AHIP)’ trial (ClinicalTrials.gov identifier: NCT01910467). Preterm neonates, who had cTOI and pTOI measurements during 24 h after birth, were included. In each neonate the mean of the cTOI/pTOI-ratio, cTOI, pTOI and routine monitoring parameters were calculated for each hour and for the 24-h measuring period. Courses of all measured parameters were analysed.ResultsEighty-seven stable preterm neonates (33.1 [32.1–34.1] weeks of gestation) were included. The mean value over the 24-h measuring period for the cTOI/pTOI-ratio was 0.96 ± 0.02, for cTOI 70.1 ± 1.4 and for pTOI 73.4 ± 0.9. Routine monitoring parameters were in the normal ranges over 24 h. The courses of the cTOI/pTOI-ratio and cTOI showed significantly lower values from hour 5 to 15 compared to the first hours after birth. Heart rate decreased significantly over time, whereas mean arterial blood pressure increased significantly. pTOI, arterial oxygen saturation and body temperature showed no significant change over time.ConclusionWe are the first to report on cTOI/pTOI-ratios for cardio-circulatory stable preterm neonates over a 24-h period after birth, showing significantly lower values from hour 5 to 15 compared to the first hours after birth.

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Precision of measurement of cerebral tissue oxygenation index using near-infrared spectroscopy in preterm neonates

Journal of Biomedical Optics ◽

10.1117/1.2357730 ◽

2006 ◽

Vol 11 (5) ◽

pp. 054005 ◽

Cited By ~ 66

Author(s):

Line C. Sorensen ◽

Gorm Greisen

Keyword(s):

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Tissue Oxygenation ◽

Oxygenation Index ◽

Preterm Neonates ◽

Cerebral Tissue ◽

Tissue Oxygenation Index ◽

Cerebral Tissue Oxygenation

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Which common NIRS variable reflects muscle estimated lactate threshold most closely?

Applied Physiology Nutrition and Metabolism ◽

10.1139/h06-069 ◽

2006 ◽

Vol 31 (5) ◽

pp. 612-620 ◽

Cited By ~ 29

Author(s):

Lixin Wang ◽

Takahiro Yoshikawa ◽

Taketaka Hara ◽

Hayato Nakao ◽

Takashi Suzuki ◽

...

Keyword(s):

Lactate Threshold ◽

Near Infrared ◽

Ventilatory Threshold ◽

Lactate Concentration ◽

Blood Lactate Concentration ◽

Oxygenation Index ◽

Muscle Lactate ◽

Tissue Oxygenation Index ◽

The Mean ◽

Tissue Hemoglobin

Various near-infrared spectroscopy (NIRS) variables have been used to estimate muscle lactate threshold (LT), but no study has determined which common NIRS variable best reflects muscle estimated LT. Establishing the inflection point of 2 regression lines for deoxyhaemoglobin (ΔHHbi.p.), oxyhaemoglobin (ΔO2Hbi.p.), and tissue oxygenation index (TOIi.p.), as well as for blood lactate concentration, we then investigated the relationships between NIRS variables and ventilatory threshold (VT), LT, or maximal tissue hemoglobin index (nTHImax) during incremental cycling exercise. ΔHHbi.p. and TOIi.p. could be determined for all 15 subjects, but ΔO2Hbi.p. was determined for only 11 subjects. The mean absolute values for the 2 measurable slopes of the 2 continuous linear regression lines exhibited increased changes in 3 NIRS variables. The workload and VO2 at ΔO2Hbi.p. and nTHImax were greater than those at VT, LT, ΔHHbi.p., and TOIi.p.. For workload and VO2, ΔHHbi.p. was correlated with VT and LT, whereas ΔO2Hbi.p. was correlated with nTHImax, and TOIi.p. with VT and nTHImax. These findings indicate that ΔO2Hb strongly corresponds with local perfusion, and TOI corresponds with both local perfusion and deoxygenation, but that ΔHHb can exactly determine deoxygenation changes and reflect O2 metabolic dynamics. The finding of strongest correlations between ΔHHb and VT or LT indicates that ΔHHb is the best variable for muscle LT estimation.

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Cerebral tissue oxygenation index in very premature infants

Archives of Disease in Childhood - Fetal and Neonatal Edition ◽

10.1136/fn.87.3.f189 ◽

2002 ◽

Vol 87 (3) ◽

pp. 189F-192 ◽

Cited By ~ 58

Author(s):

G Naulaers

Keyword(s):

Premature Infants ◽

Tissue Oxygenation ◽

Oxygenation Index ◽

Cerebral Tissue ◽

Tissue Oxygenation Index ◽

Cerebral Tissue Oxygenation ◽

Very Premature Infants

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Use of the Liver Tissue Oxygenation Index as a Noninvasive Parameter of Intestinal Ischemia in Rabbits

World Journal of Surgery ◽

10.1007/s00268-007-9269-y ◽

2007 ◽

Vol 31 (12) ◽

pp. 2359-2362 ◽

Cited By ~ 14

Author(s):

J. Vanderhaegen ◽

L. Dehing ◽

G. Naulaers ◽

H. Devlieger ◽

Y. Al-Olayet ◽

...

Keyword(s):

Liver Tissue ◽

Intestinal Ischemia ◽

Tissue Oxygenation ◽

Oxygenation Index ◽

Tissue Oxygenation Index

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Measurement of Tissue Oxygenation Index During the First Three Days in Premature Born Infants

Advances in Experimental Medicine and Biology - Oxygen Transport To Tissue XXIII ◽

10.1007/978-1-4615-0205-0_63 ◽

2003 ◽

pp. 379-383 ◽

Cited By ~ 30

Author(s):

Gunnar Naulaers ◽

Geert Morren ◽

Sabine Van Huffel ◽

Paul Casaer ◽

Hugo Devlieger

Keyword(s):

Tissue Oxygenation ◽

Oxygenation Index ◽

Tissue Oxygenation Index ◽

Premature Born

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Amplitude of Tissue Oxygenation Index Change Predicts Cerebral Hyperperfusion Syndrome During Carotid Artery Stenting

World Neurosurgery ◽

10.1016/j.wneu.2016.12.062 ◽

2017 ◽

Vol 99 ◽

pp. 548-555 ◽

Cited By ~ 4

Author(s):

Hun Soo Park ◽

Ichiro Nakagawa ◽

Shohei Yokoyama ◽

Yasushi Motoyama ◽

Young Su Park ◽

...

Keyword(s):

Carotid Artery ◽

Carotid Artery Stenting ◽

Tissue Oxygenation ◽

Oxygenation Index ◽

Cerebral Hyperperfusion Syndrome ◽

Index Change ◽

Hyperperfusion Syndrome ◽

Cerebral Hyperperfusion ◽

Tissue Oxygenation Index

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Can tissue oxygenation index (TOI) and cotside neurophysiological variables predict outcome in depressed/asphyxiated newborn infants?

Early Human Development ◽

10.1016/j.earlhumdev.2006.09.003 ◽

2007 ◽

Vol 83 (8) ◽

pp. 483-489 ◽

Cited By ~ 18

Author(s):

Patrizia Zaramella ◽

Elisabetta Saraceni ◽

Federica Freato ◽

Elena Falcon ◽

Agnese Suppiej ◽

...

Keyword(s):

Tissue Oxygenation ◽

Newborn Infants ◽

Oxygenation Index ◽

Tissue Oxygenation Index

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Near-infrared spectroscopy monitoring during out-of-hospital cardiac arrest: can the initial cerebral tissue oxygenation index predict ROSC?

Emergency Medicine Journal ◽

10.1136/emermed-2018-207533 ◽

2018 ◽

pp. emermed-2018-207533

Author(s):

Jumpei Tsukuda ◽

Shigeki Fujitani ◽

Kenichiro Morisawa ◽

Nobuhiko Shimozawa ◽

Brandon D Lohman ◽

...

Keyword(s):

Cardiac Arrest ◽

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Tissue Oxygenation ◽

Oxygenation Index ◽

Patient Death ◽

Clinical Factor ◽

Tissue Oxygenation Index ◽

Hospital Cardiac Arrest

Study objectivesNear-infrared spectroscopy is a modality that can monitor tissue oxygenation index (TOI) and has potential to evaluate return of spontaneous circulation (ROSC) during cardiopulmonary resuscitation (CPR). This study’s objectives were to evaluate whether TOI could be associated with ROSC and used to help guide the decision to either terminate CPR or proceed to extracorporeal CPR (ECPR).MethodsIn this observational study, we assessed the patients with out-of-hospital cardiac arrest with non-traumatic cause receiving CPR on arrival at our ED between 2013 and 2016. TOI monitoring was discontinued either on CPR termination after ROSC was reached or on patient death. Patients were classified into two groups: ROSC and non-ROSC group.ResultsOut of 141 patients, 24 were excluded and the remaining 117 were classified as follows: ROSC group (n=44) and non-ROSC group (n=73). ROSC group was significantly younger and more likely to have their event witnessed and bystander CPR. ROSC group showed a higher initial TOI than non-ROSC group (60.5%±17.0% vs 37.9%±13.7%: p<0.01). Area under the curve analysis was more accurate with the initial TOI than without it for predicting ROSC (0.88, 95% CI 0.82 to 0.95 vs 0.79, 95% CI 0.70 to 0.87: p<0.01). TOI cut-off value ≥59% appeared to favour survival to hospital discharge whereas TOI ≤24% was associated with non-ROSC.ConclusionsThis study demonstrated an association between higher initial TOI and ROSC. Initial TOI could increase the accuracy of ROSC prognosis and may be a clinical factor in the decision to terminate CPR and select patients who are to proceed to ECPR.

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Wearing of Cloth or Disposable Surgical Face Masks has no Effect on Vigorous Exercise Performance in Healthy Individuals

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17218110 ◽

2020 ◽

Vol 17 (21) ◽

pp. 8110

Author(s):

Keely Shaw ◽

Scotty Butcher ◽

Jongbum Ko ◽

Gordon A. Zello ◽

Philip D. Chilibeck

Keyword(s):

Oxygen Saturation ◽

Exercise Performance ◽

Tissue Oxygenation ◽

Arterial Oxygen Saturation ◽

Oxygenation Index ◽

Arterial Oxygen ◽

Time To Exhaustion ◽

Vigorous Exercise ◽

Exercise Tests ◽

Tissue Oxygenation Index

Wearing face masks is recommended for the prevention of contracting or exposing others to cardiorespiratory infections, such as COVID-19. Controversy exists on whether wearing face masks during vigorous exercise affects performance. We used a randomized, counterbalanced cross-over design to evaluate the effects of wearing a surgical mask, a cloth mask, or no mask in 14 participants (7 men and 7 women; 28.2 ± 8.7 y) during a cycle ergometry test to exhaustion. Arterial oxygen saturation (pulse oximetry) and tissue oxygenation index (indicator of hemoglobin saturation/desaturation) at vastus lateralis (near-infrared spectroscopy) were assessed throughout the exercise tests. Wearing face masks had no effect on performance (time to exhaustion (mean ± SD): no mask 622 ± 141 s, surgical mask 657 ± 158 s, cloth mask 637 ± 153 s (p = 0.20); peak power: no mask 234 ± 56 W, surgical mask 241 ± 57 W, cloth mask 241 ± 51 W (p = 0.49)). When expressed relative to peak exercise performance, no differences were evident between wearing or not wearing a mask for arterial oxygen saturation, tissue oxygenation index, rating of perceived exertion, or heart rate at any time during the exercise tests. Wearing a face mask during vigorous exercise had no discernable detrimental effect on blood or muscle oxygenation, and exercise performance in young, healthy participants (ClinicalTrials.gov, NCT04557605).

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