Surface Modification of Gold Nanostars Through the Changes on Gold Seed Concentrations

MRS Advances ◽  
2018 ◽  
Vol 3 (41) ◽  
pp. 2449-2454
Author(s):  
Juan Carlos Martinez Espinosa ◽  
Miguel Jose Yacaman ◽  
German Plascencia Villa ◽  
Victor Hugo Romero Arellano ◽  
Ana Karen Zavala Raya
Keyword(s):  
Biomedical Applications ◽  
Surface Enhanced Raman Spectroscopy ◽  
Diameter Distribution ◽  
Biological Assays ◽  
Surface Enhanced ◽  
Different Types ◽  
Surface Enhanced Raman ◽  
Gold Seed ◽  
Gold Nanomaterials ◽  
Specific Membrane

AbstractDue to its excellent optical properties, gold nanomaterials with anisotropic morphology are playing an important role in biomedical applications, specifically in the use of Surface Enhanced Raman Spectroscopy (SERS) technique for biological assays. In this work, we verified the behavior of the star shape nanoparticle peaks obtained by chemical synthesis (precursor reactant: HAuCl4, cationic surfactant: CTAB) and whose peaks were formed from the different concentrations of gold seeds (55, 65, 75 and 85 ul) which were added to the total solution (5.275 ml). The shape and size of the nanoparticles was verified with a Hitachi S-5500 microscope with a BF & DF SEM / STEM detector, and for the diameter distribution (hydrodynamic) was carried out by the dynamic light distribution technique with a Malvern DLS system Zetasizer Nano ZS. Particle sizes (peak-to-peak considering) were obtained with variations from 107 to 166 nm. The results suggest adding 75 ul of gold seeds to obtain uniform nanostars with well defined peaks. These gold nano-stars could be applied for identification of specific membrane markers for the study of different types of cancer by the SERS technique.

Nanostructured probes to enhance optical and vibrational spectroscopic imaging for biomedical applications

2017 ◽  
Author(s):  
Anil K. Kodali ◽  
Rohit Bhargava
Keyword(s):  
Raman Spectroscopy ◽  
Biomedical Applications ◽  
Spectroscopic Imaging ◽  
Surface Enhanced Raman Spectroscopy ◽  
Ultrasensitive Detection ◽  
Optical Resonances ◽  
Surface Enhanced ◽  
Different Types ◽  
Surface Enhanced Raman ◽  
Ir And Raman

This article describes the use of nanostructured probes to enhance optical and vibrational spectroscopic imaging for biomedical applications. Engineered probes and surfaces are promising tools for enhancing signals for ultrasensitive detection of diseases like carcinoma. Two methods of interest are surface-enhanced infrared absorption (SEIRA) spectroscopy and surface-enhanced Raman spectroscopy (SERS) for IR and Raman modalities, respectively. SERS and SEIRA can be broadly categorized under a common modality termed surface-enhanced vibrational spectroscopy. This article first reviews various breakthrough findings reported in SERS and SEIRA, along with different types ofsubstrates and contrast agents used in realizing the enhancement and theories proposed to explain these findings. It then considers the configurations of nano-LAMPs and presents example results demonstrating their optical resonances and tunability. Finally, it evaluates a few techniques for fabricating multilayered nanoparticles and highlights some issues with respect to fabrication.

scholarly journals Label-Free Detection of Human Serum Using Surface-Enhanced Raman Spectroscopy Based on Highly Branched Gold Nanoparticle Substrates for Discrimination of Non-Small Cell Lung Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-13
Author(s):  
Xiaowei Cao ◽  
Zhenyu Wang ◽  
Liyan Bi ◽  
Jie Zheng
Keyword(s):  
Lung Cancer ◽  
Raman Spectroscopy ◽  
Cell Lung Cancer ◽  
Surface Enhanced Raman Spectroscopy ◽  
Small Cell ◽  
Label Free ◽  
Small Cell Lung ◽  
Surface Enhanced ◽  
Different Types ◽  
Surface Enhanced Raman

Surface-enhanced Raman spectroscopy (SERS) is a good candidate for the development of fast and easy-to-use diagnostic tools, possibly used on serum in screening tests. In this study, a potential label-free serum test based on SERS spectroscopy was developed to analyze human serum for the diagnosis of the non-small cell lung cancer (NSCLC). We firstly synthesized novel highly branched gold nanoparticles (HGNPs) at high yield through a one-step reduction of HAuCl4 with dopamine hydrochloride at 60°C. Then, HGNP substrates with good reproducibility, uniformity, and high SERS effect were fabricated by the electrostatically assisted (3-aminopropyl) triethoxysilane-(APTES-) functionalized silicon wafer surface-sedimentary self-assembly method. Using as-prepared HGNP substrates as a high-performance sensing platform, SERS spectral data of serum obtained from healthy subjects, lung adenocarcinoma patients, lung squamous carcinoma patients, and large cell lung cancer patients were collected. The difference spectra among different types of NSCLC were compared, and analysis result revealed their intrinsic difference in types and contents of nucleic acids, proteins, carbohydrates, amino acids, and lipids. SERS spectra were analyzed by principal component analysis (PCA), which was able to distinguish different types of NSCLC. Considering its time efficiency, being label-free, and sensitivity, SERS based on HGNP substrates is very promising for mass screening NSCLC and plays an important role in the detection and prevention of other diseases.

scholarly journals Morphology-Controlled Versatile One-Pot Synthesis of Hydrophobic Gold Nanodots, Nanobars, Nanorods, and Nanowires and Their Applications in Surface-Enhanced Raman Spectroscopy

2019 ◽  
Vol 9 (5) ◽  
pp. 935 ◽  
Author(s):  
Jing Neng ◽  
Chen Xiang ◽  
Kan Jia ◽  
Xiaohua Nie ◽  
Peilong Sun
Keyword(s):  
Reaction Times ◽  
Surface Enhanced Raman Spectroscopy ◽  
Chloroauric Acid ◽  
One Pot ◽  
Sers Substrates ◽  
One Pot Synthesis ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Potential Applications ◽  
Gold Nanomaterials

Many previously reported syntheses of gold nanoparticles required lengthy reaction times, complicated operations, high temperatures, or multi-step manipulations. In this work, a morphology-controlled versatile one-pot synthesis of hydrophobic gold nanodots, nanobars, nanorods, and nanowires has been developed. A series of gold nanomaterials ranging from round nanodots, short nanobars, and long nanorods to ultrathin and ultralong nanowires (diameter <2 nm, length >2 μm) have been readily prepared by simply adjusting the feeding ratio of chloroauric acid to oleylamine, oleic acid, and triphenylsilane. The silk-like ultralong and ultrathin nanowires were found to have a single crystalline structure and may have significant potential applications in microelectronics and biosensors. Large sizes of gold spherical nanoparticles were obtained from gold nanodots via a seed-mediated growth approach. These nanoparticles and ultralong nanowires showed excellent surface-enhanced Raman scattering (SERS) activity in organic solvents and, therefore, were employed as efficient organic-soluble SERS substrates for the detection of hydrophobic food toxicants, such as 3,4-benzopyrene, and carcinogens, such as benzidine.

Recent progress in surface-enhanced Raman spectroscopy for biological and biomedical applications: from cells to clinics

2017 ◽  
Vol 46 (13) ◽  
pp. 3945-3961 ◽  
Author(s):  
D. Cialla-May ◽  
X.-S. Zheng ◽  
K. Weber ◽  
J. Popp
Keyword(s):  
Raman Spectroscopy ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

In this tutorial review, we summarize the recent progress in SERS-based biological and biomedical applications – from cells to clinics.

scholarly journals Bimetallic gold core–silver shell nanorod performance for surface enhanced Raman spectroscopy

RSC Advances ◽  
2017 ◽  
Vol 7 (84) ◽  
pp. 53164-53171 ◽  
Author(s):  
Zeid A. Nima ◽  
Yevgeniy R. Davletshin ◽  
Fumyia Watanabe ◽  
Karrar M. Alghazali ◽  
J. Carl Kumaradas ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Gold Nanorods ◽  
Biomedical Applications ◽  
Surface Enhanced Raman Spectroscopy ◽  
Gold Core ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Different Thickness ◽  
Silver Shell

Plasmonic gold nanorods (AuNRs) coated with four different thickness silver shells (AuNR\Ags) were synthesized and tested for their efficiency in Surface Enhanced Raman Scattering (SERS) signal enhancement for biomedical applications.

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