Silicon as an Active Biomaterial

AbstractThe response of a range of porous Si and poly Si films to storage in acellular simulated body fluids is summarised and its implications discussed. It is suggested that the combination of VLSI technology, micromachining and surface microstructuring achievable with silicon, could establish this prominent semiconductor as a very useful biomaterial by the next century. The ‘biocompatibility’ of a variety of silicon microstructures, and even bulk silicon has received surprisingly little study, but now warrants detailed in-vitro and in-vivo assessment.

Download Full-text

Apatite Nucleation on Low Porosity Silicon in Acellular Simulated Body Fluids

MRS Proceedings ◽

10.1557/proc-414-189 ◽

1995 ◽

Vol 414 ◽

Cited By ~ 4

Author(s):

L T Canham ◽

C L Reeves

Keyword(s):

Body Fluids ◽

Porous Si ◽

Bioactive Materials ◽

Simulated Body Fluids ◽

Low Levels ◽

Si Films ◽

Insight Into ◽

Low Porosity

AbstractThe response of a range of porous Si films to acellular simulated body fluids has been monitored by SEM, EDX and FTIR analyses. Quite low levels of porosity are shown here to induce hydroxyapatite growth both on top of the film, and even on neighbouring areas of bulk Si, which in isolation have no such effect. The in-vitro demonstration of hydroxyapatite nucleation by a porous semiconductor could provide further insight into the phenomenon of bioactivity and help realise a broader range of bioactive materials.

Download Full-text

Perspectives of Silicone Elastomere Implants Use in Preventing Postoperative Complications in Pelvic Exenteration for Advanced Cancers

Revista de Chimie ◽

10.37358/rc.20.1.7809 ◽

2020 ◽

Vol 71 (1) ◽

pp. 45-50

Author(s):

George Jinescu ◽

Nicolae Bacalbasa ◽

Andra Evtodiev ◽

Iulia-Adelina Marin ◽

Ioana Chiulan ◽

...

Keyword(s):

Mechanical Performance ◽

Degradation Products ◽

Hydrolytic Degradation ◽

Hardness Measurement ◽

Body Fluids ◽

Time Interval ◽

Swine Model ◽

Simulated Body Fluids

In this work, silicone elastomer films with potential to be used as implantable pelvic prosthesis were prepared and their bioactivity was studied both in vitro and in vivo environment. Tensile tests, hardness measurement and compression analysis revealed no significant decrease of the mechanical performance after in vitro hydrolytic degradation in simulated body fluids. The in vivo biocompatibility of films was assessed by implanting them subcutaneously in swine model, for 30 days. Their mechanical characteristics were similar to those of samples immersed in simulated body fluids, for the same time interval. No sign of fibrosis or necrosis were detected from the histological analysis performed on the tissue surrounding the films. In combination, these results indicate that this material has a very good resistance to mechanical and chemical fatigue, do not release any toxic degradation products and, therefore, has great potential as to be used further for preparation of pelvic prosthesis.

Download Full-text

Faculty Opinions recommendation of In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13372017.14742134 ◽

2011 ◽

Author(s):

Peter Harvison

Keyword(s):

Drug Transporters ◽

In Vivo Assessment

Download Full-text

In vitro and in vivo assessment of biocompatibility of AZ31 alloy as biliary stents: a preclinical approach

Archives of Medical Science ◽

10.5114/aoms.2020.92675 ◽

2020 ◽

Author(s):

Yong Song ◽

Gaoping Qin ◽

Lixue Du ◽

Haitian Hu ◽

Yong Han

Keyword(s):

Az31 Alloy ◽

Biliary Stents ◽

In Vivo Assessment

Download Full-text

In vivo assessment of a single adenine mutation in 5′UTR of Endothelin-1 gene in paediatric cases with severe pulmonary hypertension: an observational study

BMC Research Notes ◽

10.1186/s13104-021-05609-5 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Abhishek Kumar ◽

Minati Choudhury ◽

Sakshi Dhingra Batra ◽

Kriti Sikri ◽

Anushree Gupta

Keyword(s):

Pulmonary Hypertension ◽

Congenital Heart ◽

Small Sample Size ◽

Small Sample ◽

Severe Pulmonary Hypertension ◽

Endothelin 1 ◽

Circulating Levels ◽

In Vivo Assessment

Abstract Objective Endothelin-1 plays an important role in the pathogenesis of severe pulmonary hypertension. The + 139 ‘A’, adenine insertion variant in 5′UTR of edn1 gene has been reported to be associated with increased expression of Endothelin-1 in vitro. The aim of present study was to explore the association of this variant with the circulating levels of Endothelin-1 in vivo using archived DNA and plasma samples from 38 paediatric congenital heart disease (cyanotic and acyanotic) patients with severe pulmonary hypertension. Results The plasma Endothelin-1 levels were highly varied ranging from 1.63 to75.16 pg/ml. The + 139 ‘A’ insertion variant in 5′UTR of edn1 was seen in 8 out of 38 cases with only one acyanotic sample demonstrating homozygosity of inserted ‘A’ allele at + 139 site (4A/4A genotype). The plasma Endothelin-1 levels in children with homozygous variant 3A/3A genotype were comparable in cyanotic and acyanotic groups. Lone 4A/4A acyanotic sample had ET-1 levels similar to the median value of ET-1 associated with 3A/3A genotype and was absent in cyanotic group presumably due to deleterious higher ET-1 levels. The discussed observations, limited by the small sample size, are suggestive of homozygous adenine insertion variant posing a risk in cyanotic babies with Severe Pulmonary Hypertension.

Download Full-text