scholarly journals Prognostic role of brain natriuretic peptide in children of the first year of life with congenital heart defects: a prospective cohort study

2020 ◽  
Vol 1 (2) ◽  
pp. 10-17
Author(s):  
Irina V. Vakhlova ◽  
Ekaterina V. Saperova
Keyword(s):  
Cohort Study ◽  
Brain Natriuretic Peptide ◽  
Congenital Heart Defects ◽  
Prospective Cohort ◽  
Congenital Heart ◽  
Heart Defects ◽  
First Year ◽  
Prognostic Role ◽  
First Year Of Life

Background. Congenital heart defects (CHD) are the most common type of developmental anomalies in children. At present the early diagnosis of congestive heart failure (CHF) and CHF-associated pathologic conditions is becoming increasingly important for optimization of protocols for following up pediatric patients in the primary health care settings.Objective. The study aimed at determining the prognostic role of brain natriuretic peptide (BNP) as a diagnostic marker of CHF progression and development of CHF-associated pathological conditions in babies with CHD during the first year of life.Methods. A prospective cohort study was carried out in a total of 114 children of the first year of life. The main study group was comprised of 61 children with confirmed diagnosis of CHD, and the control group of 53 health status group I–IIA children without CHD.Results. Diagnostic role of BNP elevation > 30 pg/mL was determined. At this BNP level the risk for developing stage 2A CHF increased 7-fold (OR 7.5 [1.8–31.5]), for developing functional class (FC) 2 CHF — nearly 5-fold (OR 4.6 [1.3–16.0]), and for FC 3 CHF such risk increased 9-fold (OR 9.2 [2.3–36.1]). Our results demonstrated that the BNP level measurements can be used in clinical practice to determine the likelihood of persistence of symptoms of perinatal CNS injuries during the first year of life (OR 7.6 [1.7–34.5]) and protein and energy deficit (PED) (OR 9.5 [2.5–35.5]) in children with CHD.

scholarly journals Prognostic role of brain natriuretic peptide in children of the first year of life with congenital heart defects: a prospective cohort study

2020 ◽  
Vol 1 (2) ◽  
pp. 10-17
Author(s):  
Irina V. Vakhlova ◽  
Ekaterina V. Saperova
Keyword(s):  
Cohort Study ◽  
Brain Natriuretic Peptide ◽  
Congenital Heart Defects ◽  
Prospective Cohort ◽  
Congenital Heart ◽  
Heart Defects ◽  
First Year ◽  
Prognostic Role ◽  
First Year Of Life

Background. Congenital heart defects (CHD) are the most common type of developmental anomalies in children. At present the early diagnosis of congestive heart failure (CHF) and CHF-associated pathologic conditions is becoming increasingly important for optimization of protocols for following up pediatric patients in the primary health care settings.Objective. The study aimed at determining the prognostic role of brain natriuretic peptide (BNP) as a diagnostic marker of CHF progression and development of CHF-associated pathological conditions in babies with CHD during the first year of life.Methods. A prospective cohort study was carried out in a total of 114 children of the first year of life. The main study group was comprised of 61 children with confirmed diagnosis of CHD, and the control group of 53 health status group I–IIA children without CHD.Results. Diagnostic role of BNP elevation > 30 pg/mL was determined. At this BNP level the risk for developing stage 2A CHF increased 7-fold (OR 7.5 [1.8–31.5]), for developing functional class (FC) 2 CHF — nearly 5-fold (OR 4.6 [1.3–16.0]), and for FC 3 CHF such risk increased 9-fold (OR 9.2 [2.3–36.1]). Our results demonstrated that the BNP level measurements can be used in clinical practice to determine the likelihood of persistence of symptoms of perinatal CNS injuries during the first year of life (OR 7.6 [1.7–34.5]) and protein and energy deficit (PED) (OR 9.5 [2.5–35.5]) in children with CHD.

scholarly journals Prognostic role of brain natriuretic peptide in children of the first year of life with congenital heart defects: a prospective cohort study

2020 ◽  
Vol 1 (2) ◽  
pp. 10-17
Author(s):  
Irina V. Vakhlova ◽  
Ekaterina V. Saperova
Keyword(s):  
Cohort Study ◽  
Brain Natriuretic Peptide ◽  
Congenital Heart Defects ◽  
Prospective Cohort ◽  
Congenital Heart ◽  
Heart Defects ◽  
First Year ◽  
Prognostic Role ◽  
First Year Of Life

Background. Congenital heart defects (CHD) are the most common type of developmental anomalies in children. At present the early diagnosis of congestive heart failure (CHF) and CHF-associated pathologic conditions is becoming increasingly important for optimization of protocols for following up pediatric patients in the primary health care settings.Objective. The study aimed at determining the prognostic role of brain natriuretic peptide (BNP) as a diagnostic marker of CHF progression and development of CHF-associated pathological conditions in babies with CHD during the first year of life.Methods. A prospective cohort study was carried out in a total of 114 children of the first year of life. The main study group was comprised of 61 children with confirmed diagnosis of CHD, and the control group of 53 health status group I–IIA children without CHD.Results. Diagnostic role of BNP elevation > 30 pg/mL was determined. At this BNP level the risk for developing stage 2A CHF increased 7-fold (OR 7.5 [1.8–31.5]), for developing functional class (FC) 2 CHF — nearly 5-fold (OR 4.6 [1.3–16.0]), and for FC 3 CHF such risk increased 9-fold (OR 9.2 [2.3–36.1]). Our results demonstrated that the BNP level measurements can be used in clinical practice to determine the likelihood of persistence of symptoms of perinatal CNS injuries during the first year of life (OR 7.6 [1.7–34.5]) and protein and energy deficit (PED) (OR 9.5 [2.5–35.5]) in children with CHD.

Hox and Tale transcription factors in heart development and disease

2018 ◽  
Vol 62 (11-12) ◽  
pp. 837-846 ◽  
Author(s):  
Fabienne Lescroart ◽  
Stephane Zaffran
Keyword(s):  
Transcription Factors ◽  
Congenital Heart Defects ◽  
Heart Development ◽  
Congenital Heart ◽  
Hox Genes ◽  
Heart Defects ◽  
First Year ◽  
First Year Of Life ◽  
Cardiac Mesoderm

Hox genes are highly conserved transcription factors with critical functions during development, in particular for patterning the antero-posterior axis of the embryo. Their action is very often associated with cofactors including the TALE family transcription factors. From Drosophila to vertebrates, Hox genes have been shown to have a major role in heart development. In this review, we focus on the increasing evidence implicating the anterior Hox genes and the Tale family members during heart development both in the cardiac mesoderm and in neural crest cells. Congenital heart defects are the leading cause of death in the first year of life and a better understanding of the role of Hox and Tale factors is highly relevant to human pathologies and will provide novel mechanistic insights into the underlying defects.

scholarly journals Maternal psychological distress, education, household income, and congenital heart defects: a prospective cohort study from the Japan environment and children’s study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yasuaki Saijo ◽  
Eiji Yoshioka ◽  
Yukihiro Sato ◽  
Hiroshi Azuma ◽  
Yusuke Tanahashi ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Cohort Study ◽  
Psychological Distress ◽  
Congenital Heart Defects ◽  
Household Income ◽  
Prospective Cohort ◽  
Congenital Heart ◽  
Maternal Education ◽  
Heart Defects ◽  
Maternal Psychological Distress

Abstract Background The influence of maternal psychological distress on infant congenital heart defects (CHDs) has not been thoroughly investigated. Furthermore, there have been no reports on the combined effect of maternal psychological distress and socioeconomic status on infant CHDs. This study aimed to examine whether maternal psychological distress, socioeconomic status, and their combinations were associated with CHD. Methods We conducted a prospective cohort study using data from the Japan Environment and Children’s Study, which recruited pregnant women between 2011 and 2014. Maternal psychological distress was evaluated using the Kessler Psychological Distress Scale in the first trimester, while maternal education and household income were evaluated in the second and third trimesters. The outcome of infant CHD was determined using the medical records at 1 month of age and/or at birth. Crude- and confounder-adjusted logistic regression analyses were performed to evaluate the association between maternal psychological distress and education and household income on infant CHD. Results A total of 93,643 pairs of mothers and infants were analyzed, with 1.1% of infants having CHDs. Maternal psychological distress had a significantly higher odds ratio in the crude analysis but not in the adjusted analysis, while maternal education and household income were statistically insignificant. In the analysis of the combination variable of lowest education and psychological distress, the P for trend was statistically significant in the crude and multivariate model excluding anti-depressant medication, but the significance disappeared in the full model (P = 0.050). Conclusions The combination of maternal psychological distress and lower education may be a possible indicator of infant CHD.

A prospective cohort study on association of first-trimester serum biomarkers and risk of isolated fetal congenital heart defects

Biomarkers ◽  
2021 ◽  
pp. 1-5
Author(s):  
Mohammad Nasir Hematian ◽  
Kamran Hessami ◽  
Shirin Torabi ◽  
Maasoumeh Saleh ◽  
Behnaz Nouri ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Congenital Heart Defects ◽  
Prospective Cohort ◽  
Congenital Heart ◽  
Heart Defects ◽  
First Trimester ◽  
Serum Biomarkers

scholarly journals VP21.05: Prevalence of growth restriction at birth for newborns with congenital heart defects: a population‐based prospective cohort study

2021 ◽  
Vol 58 (S1) ◽  
pp. 184-184
Author(s):  
A. Ghanchi ◽  
M. Rahshenas ◽  
D. Bonnet ◽  
N. Derridj ◽  
N. Lelong ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Congenital Heart Defects ◽  
Prospective Cohort ◽  
Congenital Heart ◽  
Heart Defects ◽  
Population Based ◽  
Growth Restriction

Prevalence of growth restriction at birth for newborns with congenital heart defects: A population-based prospective cohort study

2021 ◽  
Vol 13 (4) ◽  
pp. 275
Author(s):  
A. Ghanchi. ◽  
M. Rahshenas ◽  
D. Bonnet ◽  
N. Derridj ◽  
N. LeLong ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Congenital Heart Defects ◽  
Prospective Cohort ◽  
Congenital Heart ◽  
Heart Defects ◽  
Population Based ◽  
Growth Restriction

scholarly journals Influence of ethnic origin on the pattern of congenital heart defects in the first year of life.

Heart ◽  
1995 ◽  
Vol 73 (2) ◽  
pp. 173-176 ◽  
Author(s):  
M. Sadiq ◽  
O. Stumper ◽  
J. G. Wright ◽  
J. V. De Giovanni ◽  
C. Billingham ◽  
...  
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Ethnic Origin ◽  
First Year ◽  
First Year Of Life

scholarly journals Maternal Psychological Distress, Education, Household Income, and Congenital Heart Defects: A Prospective Cohort Study from The Japan Environment and Children’s Study Running Title Maternal Psychological Distress and Congenital Heart Defects

2021 ◽  
Author(s):  
Yasuaki Saijo ◽  
Eiji Yoshioka ◽  
Yukihiro Sato ◽  
Hiroshi Azuma ◽  
Yusuke Tanahashi ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Cohort Study ◽  
Psychological Distress ◽  
Congenital Heart Defects ◽  
Household Income ◽  
Prospective Cohort ◽  
Congenital Heart ◽  
Maternal Education ◽  
Heart Defects ◽  
Maternal Psychological Distress

Abstract Background: The influence of maternal psychological distress on infant congenital heart defects (CHDs) has not been thoroughly investigated. Furthermore, there have been no reports on the combined effect of maternal psychological distress and socioeconomic status on infant CHDs. This study aimed to examine whether maternal psychological distress, socioeconomic status, and their combinations were associated with CHD.Methods: We conducted a prospective cohort study using data from the Japan Environment and Children’s Study, which recruited pregnant women between 2011 and 2014. Maternal psychological distress was evaluated using the Kessler Psychological Distress Scale in the first trimester, while maternal education and household income were evaluated in the second and third trimesters. The outcome of infant CHD was determined using the medical records at 1 month of age and/or at birth. Crude and adjusted logistic regression analyses were performed to evaluate the association between maternal psychological distress and education and household income on infant CHD.Results: A total of 93,643 pairs of mothers and infants were analyzed, with 1.1% of infants having CHDs. Maternal psychological distress had a significantly higher odds ratio in the crude analysis but not in the adjusted analysis, while maternal education and household income were statistically insignificant. In the analysis of the combination variable of lowest education and psychological distress, the trend for p was statistically significant in the crude and adjusted analyses.Conclusions: The combination of maternal psychological distress and lower education may be a possible indicator of infant CHD.

The incidence of congenital heart defects in the first year of life

1993 ◽  
Vol 29 (5) ◽  
pp. 344-349 ◽  
Author(s):  
S. A. KIDD ◽  
P. A. L. LANCASTER ◽  
R. M. McCREDIE
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
First Year ◽  
First Year Of Life
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