Pleural plaques: markers of asbestos exposure or independent risk factor for pleural mesothelioma? A case report of mesothelioma developed on a pleural plaque in a worker with occupational asbestos exposure

62-year-old man with shortness of breath and an abnormal chest CT Axial 3D SPGR postgadolinium images (Figure 13.8.1) demonstrate diffuse thickening and enhancement of the left pleura, with a few minimally enhancing, focal right-sided pleural plaques. Malignant pleural mesothelioma Malignant pleural mesothelioma is a rare neoplasm that originates from the mesothelial cells lining the visceral and parietal pleura. The incidence of malignant pleural mesothelioma in the United States is 15 cases per million; there is a strong correlation with asbestos exposure. Malignant pleural mesothelioma is divided into 3 histologic subtypes: epithelial (55%-65%), sarcomatoid (10%-15%), and mixed (20%-35%). Patients with epithelial malignant pleural mesothelioma have the best prognosis, and among those with limited disease who undergo extrapleural pneumonectomy (removal of the pleura, lung, hemidiaphragm, and part of the pericardium), survival is longer (5-year survival, 39%) than among all patients (median survival, 8-18 months after diagnosis)....

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Lung Asbestos Fibre Burden and Pleural Mesothelioma in Women with Non-occupational Exposure

Annals of Work Exposures and Health ◽

10.1093/annweh/wxaa009 ◽

2020 ◽

Vol 64 (3) ◽

pp. 297-310

Author(s):

Pietro Gino Barbieri ◽

Anna Somigliana ◽

Yao Chen ◽

Dario Consonni ◽

Roberto Vignola ◽

...

Keyword(s):

Occupational Exposure ◽

Asbestos Exposure ◽

Body Burden ◽

Pleural Mesothelioma ◽

Asbestos Fibre ◽

Pleural Plaques ◽

Group 3 ◽

Group 2 ◽

Asbestos Body ◽

Group 1

Abstract Background Malignant pleural mesothelioma (MPM) due to environmental and familial (domestic) asbestos exposure is well recognized. However, information on cumulative asbestos dose in subjects affected by MPM is limited. Objectives To evaluate the residual lung asbestos fibre and asbestos body burden in women with MPM with past environmental and/or familial asbestos exposure. Methods We collected lung samples from autopsies regarding 15 non-occupationally asbestos-exposed MPM cases, divided in three groups: (i) familial exposure from the Fincantieri shipyards in Monfalcone (No. 7), (ii) environmental and familial asbestos exposure from the asbestos-cement plant Fibronit in Broni (No. 6), and (iii) environmental exposure from the Fibronit plant (No. 2). Asbestos body (AB) and fibres (AF) per gram of dry lung tissue were counted by optical and scanning electron microscopy, respectively, and expressed as geometric means and standard deviations (GM, GSD). Results GM/GSD of AB counts were 6123/9.6 (Group 1), 13 800/10.4 (Group 2), and 8400/1.1 (Group 3); GM/GSD of AF were 0.6/2.1 (Group 1), 7.9/2.1 (Group 2), and 6.0/2.3 (Group 3) million. Pleural plaques were observed in 12 cases. Conclusions Exclusive familial exposure to asbestos determined cumulative doses close to those observed in moderate occupational exposure circumstances. Our results also suggest that combined environmental and familial exposures may cause unexpectedly high cumulative fibre doses.

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Asymptomatic Benign Pleural Plaque Due to Asbestos Exposure in Former TB Patient: A Case Report

Clinical Medical Reviews and Case Reports ◽

10.23937/2378-3656/1410247 ◽

2018 ◽

Vol 5 (12) ◽

Author(s):

Susanto Agus Dwi ◽

Jonathan Steven

Keyword(s):

Case Report ◽

Asbestos Exposure ◽

Pleural Plaque

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Postpartum diastasis of the pubic symphysis: case report and literature review

Lietuvos chirurgija ◽

10.15388/lietchirur.2015.2.8249 ◽

2015 ◽

Vol 14 (2) ◽

pp. 105-110

Author(s):

Valentinas Uvarovas ◽

Povilas Žukauskas ◽

Tadas Šiatkus ◽

Povilas Masionis

Keyword(s):

Chronic Pain ◽

Risk Factor ◽

Case Report ◽

Literature Review ◽

Postpartum Period ◽

Independent Risk Factor ◽

Pubic Symphysis ◽

Normal Delivery ◽

Clinical Challenge ◽

Pelvic Instability

Postpartum diastasis of the pubic symphysis has the incidence from 1 in 300 to 1 in 30,000 deliveries. Under the action of progesterone and relaxin, a 1 cm widening of pubic symphysis is considered to be physiological and necessary for normal delivery. However, any higher widening is always pathological, involving the damage of pubic and sacroiliac ligaments. Multiparity has been identified as the only independent risk factor. Because this pathology often manifests as chronic pain in the pubic symphysis region, it is often mistakenly stated as a normal postpartum occurrence. It is only later when the symptoms of pelvic instability and pubic osteitis appear. Postpartum symphysiolysis is a clinical challenge to a physician due to low awareness and the postpartum period important to both the patient and the newborn.

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