scholarly journals Cardiovascular risk stratification in stable coronary artery disease based on prognostic scores and models

2020 ◽  
Vol 19 (3) ◽  
pp. 2528
Author(s):  
S. N. Tolpygina ◽  
S Yu. Martsevich
Keyword(s):  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Risk Stratification ◽  
Stable Coronary Artery Disease ◽  
Prognostic Scores ◽  
Prognostic Models ◽  
Unified Approach ◽  
Cardiovascular Risk Stratification ◽  
Artery Disease

According to modern clinical guidelines, the strategy of examination and treatment of a patient with stable coronary artery disease depends on the prognosis. Despite the great number of prognostic models and scores, there is currently no unified approach for cardiovascular risk stratification. The article provides a literature review of the main current prognostic models and scores, taking into account their effectiveness and limitations.

scholarly journals Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients

2013 ◽  
Vol 35 (13) ◽  
pp. 844-852 ◽  
Author(s):  
Eleni Rapsomaniki ◽  
Anoop Shah ◽  
Pablo Perel ◽  
Spiros Denaxas ◽  
Julie George ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Electronic Health Record ◽  
Stable Coronary Artery Disease ◽  
Prognostic Models ◽  
Health Record ◽  
Electronic Health ◽  
Artery Disease

scholarly journals Cardiac risk stratification in stable coronary artery disease

The Clinician ◽  
2020 ◽  
Vol 14 (1-2) ◽  
pp. 24-33
Author(s):  
S. N. Tolpygina ◽  
S. Yu. Martsevich
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Stratification ◽  
Myocardial Revascularization ◽  
Cardiovascular Complications ◽  
Prognostic Models ◽  
High Tech ◽  
Risk Of Death ◽  
Artery Disease ◽  
Stable Cad

Despite a gradually decreased mortality from cardiovascular diseases, including coronary artery disease (CAD), they remain the main cause of death in the world. In the coming decades, an increased prevalence of CAD is expected. While methods that are more sensitive are used to diagnose CAD and mortality of the acute forms decreases due to high-tech treatment methods, the prevalence of CAD chronic forms is gradually increasing. According to the modern clinical guidelines, examination and treatment of a particular patient with stable CAD depends on its prognosis, since only in high-risk patients myocardial revascularization can improve life prognosis, however, most patients receive unified therapy. Despite the fact that there are many prognostically significant factors, models and indices developed to assess the risk of death and cardiovascular complications in CAD, a unified approach to risk stratification does not currently exist. The article provides a literary review of how historically the main prognostically significant signs were identified (including clinical anamnestic and psychosocial characteristics, comorbidity, data of non-invasive instrumental studies such as electrocardiography, echocardiography, tests with dosed physical activity, invasive coronary angiography and some of the existing prognostic models and indices that can help a practitioner in stratifying the risk of cardiovascular complications in a patient with stable CAD.

scholarly journals Associations of adipocytokine expression and cardiovascular risk factors in stable coronary artery disease

2021 ◽  
Vol 26 (3) ◽  
pp. 4318
Author(s):  
E. V. Belik ◽  
O. V. Gruzdeva ◽  
Yu. A. Dyleva ◽  
D. A. Borodkina ◽  
M. Yu. Sinitsky ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Adipose Tissue ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Stable Coronary Artery Disease ◽  
Perivascular Adipose Tissue ◽  
Fat Depots ◽  
Artery Disease

Aim. To determine the expression of adiponectin, leptin and I interleukin-6 (IL-6) in subcutaneous, epicardial and perivascular adipose tissue, depending on the presence of cardiovascular risk factors.Material and methods. The study included 90 patients with stable coronary artery disease (CAD) who underwent coronary artery bypass grafting. Samples of adipose tissue were obtained during surgery. The levels of matrix ribonucleic acid (mRNA) of the studied adipocytokines were determined in the presence/absence of the main cardiovascular risk factors.Results. Differences in the expression of genes of the studied adipocytokines in different sex and age groups of patients were revealed, depending on the tissue belonging of adipocytes. Expression of adiponectin in the epicardial and perivascular adipose tissue (EАT and PVAT, respectively), as well as of leptin in the PVAT was less pronounced in men. However, the level of IL-6 mRNA in the subcutaneous adipose tissue (SAT) of men was three times higher than in women, and in the PVAT it was lower. The maximum expression of leptin and IL-6 in the EAT and PVAT was found in persons aged 50-59 years. The presence of dyslipidemia is associated with a decrease in the expression of adiponectin in the EAT, PVAT, and IL-6 in the PVAT. In patients with hypertension (HTN), there was a low level of adiponectin mRNA in the EAT against the background of high leptin levels in the EAT and IL-6 in SAT and EAT. In hypertension with a duration of more than 20 years, there was a decrease in adiponectin expression and an increase in leptin in all types of AT. In smokers, an increase in the expression of adiponectin in the SAT, EAT, PVAT and leptin in the SAT, EAT was found.Conclusion. Associations of traditional cardiovascular risk factors with imbalance of adipocytokines of local fat depots in patients with CAD were revealed. The detected imbalance is manifested by a decrease in the expression of cardioprotective adiponectin in the EAT, PVAT, an increase in leptin and IL-6, which is an unfavorable sign. The presence of such risk factors as male sex, age of 50-59 years, dyslipidemia and hypertension in patients can enhance atherogenesis and contribute to the further progression of CAD.

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