Observations on the Activities of Certain Serum Enzymes and Levels of Some Biochemical Parameters in Spent Horses with Liver Damage

Clinical biochemistry tests are one of the tests designed to assess the functional status of the liver in domestic animals and man. This study evaluated the activities of some serum enzymes and the level of some biochemical parameters in horses with acute and chronic liver damage. This study was carried out in Nigerian horses presented for sale at the Obollo Afor horse depot, Udenu Local Government Area, Enugu State Nigeria. A total of 100 adult Nigerian horses of either sex were studied once a week for a period of 24 weeks. Serum biochemistry parameters indicated for the assessment of liver function were evaluated following standard procedures. These parameters include: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total proteins, albumin, globulin, total cholesterol, total bilirubin and urea. Based on the outcome of the serum biochemistry evaluation, the horses were assigned into 3 groups namely: apparently healthy horses (Group 1), horses with biochemical markers of acute liver damage (Group 2) and horses with biochemical markers of chronic liver damage (Group 3). The mean serum ALT, AST, ALP and total bilirubin values of group 2 horses were significantly (p < 0.05) higher than those of groups 1 and 3 horses. The mean serum albumin value of group 2 horses was significantly (p < 0.05) lower than that of groups 1 and 3 horses. There was no significant (p > 0.05) difference in the mean serum urea value of group 2 and 3. A significantly (p < 0.05) lower serum creatinine value was observed in group 2 horses. There were no significant (p > 0.05) differences in the mean serum total protein, globulin and cholesterol values across the groups. In the spent horses, acute liver damage was characterized by increased serum ALT, AST and ALP activities, and decrease in creatinine level, hyperbilirubinemia, slight hypoalbuminemia, normal total protein, globulin and cholesterol levels while chronic liver damage was characterized by decreased serum ALT activity, normal serum AST and ALP activities, decreased serum urea level, normal total protein, albumin, globulin, total bilirubin and cholesterol levels.

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IFN-gamma inhibits hepatic progenitor cell activation in chronic liver damage

Zeitschrift für Gastroenterologie ◽

10.1055/s-0030-1269507 ◽

2011 ◽

Vol 49 (01) ◽

Author(s):

H Weng ◽

S Radaeva ◽

Y Liu ◽

Q Li ◽

H Shen ◽

...

Keyword(s):

Liver Damage ◽

Progenitor Cell ◽

Cell Activation ◽

Chronic Liver ◽

Hepatic Progenitor Cell ◽

Chronic Liver Damage ◽

Ifn Gamma

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Biliary hyperplasia and carcinogenesis in chronic liver damage induced in rats by phomopsin

Pathology ◽

10.3109/00313029009086665 ◽

1990 ◽

Vol 22 (4) ◽

pp. 213-222 ◽

Cited By ~ 11

Author(s):

John E. Peterson

Keyword(s):

Liver Damage ◽

Chronic Liver ◽

Chronic Liver Damage

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Editorial Expression of Concern: Tumor necrosis factor-inducible gene 6 protein ameliorates chronic liver damage by promoting autophagy formation in mice

Experimental & Molecular Medicine ◽

10.1038/s12276-021-00554-6 ◽

2021 ◽

Author(s):

Sihyung Wang ◽

Chanbin Lee ◽

Jieun Kim ◽

Jeongeun Hyun ◽

Minso Lim ◽

...

Keyword(s):

Tumor Necrosis Factor ◽

Liver Damage ◽

Tumor Necrosis ◽

Chronic Liver ◽

Chronic Liver Damage ◽

Necrosis Factor ◽

Inducible Gene

An Editorial Expression of Concern to this paper has been published: https://doi.org/10.1038/s12276-021-00554-6

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TOLAK UKUR FUNGSI HATI BERDASARKAN DERAJAT FIBROSIS PENYAKIT HATI KRONIS (Liver Function Parameters based on Degree of Liver Fibrosis in Chronic Liver Disease)

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v21i1.1260 ◽

2018 ◽

Vol 21 (1) ◽

pp. 57

Author(s):

Rahmafitria Rahmafitria ◽

Mutmainnah Mutmainnah ◽

Ibrahim Abdul Samad

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Liver Function ◽

Chronic Liver Disease ◽

Total Bilirubin ◽

Chronic Liver ◽

Low Degree ◽

Significant Difference ◽

The Mean ◽

High Degree

Evaluating the degree of liver fibrosis degree is invasive as well as uncomfortable, therefore, non invasive examinations such as liverfunction tests and elastography (Fibro Scan) as a predictor‘s device of liver fibrosis degree are necessary. The aim of this study was toknow the differences of liver function parameters based on the fibrosis degree in patients with chronic liver disease. This study was a crosssectional design using data from chronic liver disease patients treated at the Dr. Wahidin Sudirohusodo Hospital. The elasticity of the liverwas measured using a fibro scan device during June 2010–July 2011. The analysis was carried out by ANOVA test on various parametersof liver function particularly on the fibrosis degree in chronic liver disease. In this study PT, albumin, total bilirubin and platelet countshowed a significant difference of 0.019, 0.009, 0.017 and 0.000 respectively. The mean values of PT and total bilirubin were significantlyhigher in the high degree of fibrosis compared to those with medium and low degree of fibrosis in the chronic liver disease patients. Basedon this study, the mean albumin levels and platelet count were significantly lower in the high degree of fibrosis compared with the mediumand low degree of fibrosis, however, no significant differences in AST, ALT, APTT and GGT were found.

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