Engineering a new generation of hemostatic agents: highlights of the Scientific Session on Hemostasis at the 2013 meeting of the American Society of Hematology

2014 ◽  
Vol 7 (3) ◽  
pp. 343-345 ◽  
Author(s):  
Maureane Hoffman
2009 ◽  
Vol 133 (9) ◽  
pp. 1413-1419 ◽  
Author(s):  
Mark D. Gustavson ◽  
Brian Bourke-Martin ◽  
Dylan Reilly ◽  
Melissa Cregger ◽  
Christine Williams ◽  
...  

Abstract Context.—There is critical need for standardization of HER2 immunohistochemistry testing in the clinical laboratory setting. Recently, the American Society of Clinical Oncology and the College of American Pathologists have submitted guidelines recommending that laboratories achieve 95% concordance between assays and observers for HER2 testing. Objective.—As a potential aid to pathologists for achieving these new guidelines, we have conducted an examination using automated quantitative analysis (AQUA analysis) to provide a standardized HER2 immunohistochemistry expression score across instruments (sites), operators, and staining runs. Design.—We analyzed HER2 expression by immunohistochemistry in a cohort (n = 669) of invasive breast cancers in tissue microarray format across different instruments (n = 3), operators (n = 3), and staining runs (n = 3). Using light source, instrument calibration techniques, and a new generation of image analysis software, we produced normalized AQUA scores for each parameter and examined their reproducibility. Results.—The average percent coefficients of variation across instruments, operators, and staining runs were 1.8%, 2.0%, and 5.1%, respectively. For positive/negative classification between parameters, concordance rates ranged from 94.5% to 99.3% for all cases. Differentially classified cases only occurred around the determined cut point, not over the entire distribution. Conclusions.—These data demonstrate that AQUA analysis can provide a standardized HER2 immunohistochemistry test that can meet current guidelines by the American Society of Clinical Oncology/College of American Pathologists. The use of AQUA analysis could allow for standardized and objective HER2 testing in clinical laboratories.


Worldview ◽  
1971 ◽  
Vol 14 (9) ◽  
pp. 13-15
Author(s):  
Ronald J. Stupak

Many intellectuals sensed the dawning of a "new generation" in the activism, idealism, and moral pronouncements of the student movement of the 1960's. This movement seemed to be reaching fruition with the "revolutionary" tremors that the youth culture let loose on college campuses and throughout American society in the wake of Cambodia, Kent State, and Jackson State during the spring of 1970.But less than six months later, the "sounds of silence" on the college campuses became deadening, and the savants of the "new society" expressed disillusionment and bewilderment.


Author(s):  
Takeyuki Tsuda

This book explores the contemporary ethnic experiences of Japanese Americans from the second to the fourth generations and the extent to which they remain connected to their ancestral cultural heritage. As one of the oldest groups of Asian Americans in the United States, most Japanese Americans are culturally assimilated and well-integrated in mainstream American society. However, they continue to be racialized as culturally “Japanese” foreigners simply because of their Asian appearance in a multicultural America where racial minorities are expected to remain ethnically distinct. Different generations of Japanese Americans have responded to such pressures in ways that range from demands that their racial citizenship as bona fide Americans be recognized to a desire to maintain or recover their ethnic heritage and reconnect with their ancestral homeland. This ethnographic study argues that the ethnicity of immigrant-descent minorities does not simply follow a linear trajectory in which increasing assimilation gradually erodes the significance of ethnic heritage and identity over generations. While inheriting the assimilative patterns of previous generations, each new generation of Japanese Americans has also negotiated its own ethnic positionality in response to a confluence of various historical and contemporary factors. In addition, this book analyzes the performance of ethnic heritage through taiko drumming ensembles, as well as placing Japanese Americans in transnational and diasporic contexts.


The Construction of Whiteness is an interdisciplinary collection of essays that examines the crucial intersection between whiteness as a privileged racial category and the various material practices (i.e. social, cultural, political, and economic) that underwrite its ideological influence in American society. In truth, whiteness has rarely been understood outside of academic circles as a problem to be examined, questioned, or interrogated. This is because the ubiquity of whiteness—its pervasive quality as an ideal that is at once omnipresent and invisible—makes it the very epitome of the social and cultural mainstream in America. Yet the undeniable relationship between whiteness and structures of inequality in this country necessitate a thorough interrogation of its formation, its representation, and its reproduction. The essays in this collection seek to do just that; that is, interrogate whiteness as a social construction, thereby revealing the underpinnings of narratives that fosters white skin as the ideal standard of beauty, intelligence, and power. The essays in this collection examine whiteness from several disciplinary perspectives, including history, communication, law, sociology, and literature. Its breadth and depth makes The Construction of Whiteness a standard anthology for introducing the critical study of race to a new generation of scholars, undergraduates, and graduate students. Moreover, the interdisciplinary approach of the collection will necessarily appeal to those with scholarly orientations in African and African American Studies, Ethnic Studies and Cultural Studies, Legal Studies, etc. This collection, therefore, makes an important contribution to the field of whiteness studies, broadly conceived, in its multifaceted connections to American history and culture.


1992 ◽  
Vol 4 (1) ◽  
pp. 94-99

These abstracts are from the Annual Scientific Session of the North American Society of Pediatric Exercise Medicine held in Aspen, Colorado, August 9-11, 1991.


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