Prevalence and correlates of sleep disorders in Parkinson’s disease: a polysomnographic study

Objective Sleep disorders in Parkinson’s disease are very common. Polysomnography (PSG) is considered the gold standard for diagnosis. The aim of the present study is to assess the prevalence of nocturnal sleep disorders diagnosed by polysomnography and to determine the associated clinical factors. Method A total of 120 patients with Parkinson’s disease were included. All patients underwent a standardized overnight, single night polysomnography. Results Ninety-four (78.3%) patients had an abnormal PSG. Half of the patients fulfilled criteria for sleep apnea-hypopnea syndrome (SAHS); rapid eye movement behavior disorder (RBD) was present in 37.5%. Characteristics associated with SAHS were age (p = 0.049) and body mass index (p = 0.016). Regarding RBD, age (p < 0.001), left motor onset (p = 0.047) and levodopa equivalent dose (p = 0.002) were the main predictors. Conclusion SAHS and RBD were the most frequent sleep disorders. Higher levodopa equivalent dose and body mass index appear to be risk factors for RBD and SAHS, respectively.

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Body mass index in Parkinson’s disease: A meta-analysis

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2011.10.016 ◽

2012 ◽

Vol 18 (3) ◽

pp. 263-267 ◽

Cited By ~ 78

Author(s):

Marjolein A. van der Marck ◽

Heleen C. Dicke ◽

Ergun Y. Uc ◽

Zippora H.A. Kentin ◽

George F. Borm ◽

...

Keyword(s):

Parkinson’S Disease ◽

Body Mass Index ◽

Parkinson's Disease ◽

Body Mass ◽

Meta Analysis

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Rapid eye movement behavior disorder in drug-naïve patients with Parkinson’s disease

Journal of Clinical Neuroscience ◽

10.1016/j.jocn.2018.07.007 ◽

2019 ◽

Vol 59 ◽

pp. 254-258 ◽

Cited By ~ 7

Author(s):

Hui Liu ◽

Ruwei Ou ◽

Qianqian Wei ◽

Yanbing Hou ◽

Bei Cao ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Eye Movement ◽

Behavior Disorder ◽

Movement Behavior ◽

Rapid Eye Movement ◽

Drug Naïve

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Incidence of treatment-emergent adverse events in Parkinson's Disease patients according to baseline body mass index: Post-hoc analysis from double-blind combined BIPARK-I and II data

Journal of the Neurological Sciences ◽

10.1016/j.jns.2019.10.1167 ◽

2019 ◽

Vol 405 ◽

pp. 200

Author(s):

R. Costa ◽

J. Ferreira ◽

A. Lees ◽

E. Tolosa ◽

W. Poewe ◽

...

Keyword(s):

Parkinson’S Disease ◽

Body Mass Index ◽

Parkinson's Disease ◽

Adverse Events ◽

Body Mass ◽

Baseline Body Mass Index ◽

Double Blind ◽

Post Hoc Analysis ◽

Post Hoc

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1.157 Body mass index is reduced in Parkinson's disease

Parkinsonism & Related Disorders ◽

10.1016/s1353-8020(08)70429-2 ◽

2007 ◽

Vol 13 ◽

pp. S48

Author(s):

Z. Adwan

Keyword(s):

Parkinson’S Disease ◽

Body Mass Index ◽

Parkinson's Disease ◽

Body Mass

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Relationship between changes of body mass index (BMI) and cognitive decline in Parkinson's disease (PD)

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2011.06.022 ◽

2012 ◽

Vol 55 (1) ◽

pp. 70-72 ◽

Cited By ~ 30

Author(s):

Hyun Jung Kim ◽

Eung Seok Oh ◽

Ji Hee Lee ◽

Jung Soo Moon ◽

Ji Eun Oh ◽

...

Keyword(s):

Parkinson’S Disease ◽

Body Mass Index ◽

Parkinson's Disease ◽

Cognitive Decline ◽

Body Mass

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Body mass index in Parkinson's disease

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2005.02.001 ◽

2005 ◽

Vol 11 (6) ◽

pp. 407 ◽

Cited By ~ 1

Author(s):

Renato P. Munhoz ◽

Carolina B. Ribas

Keyword(s):

Parkinson’S Disease ◽

Body Mass Index ◽

Parkinson's Disease ◽

Body Mass

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Parkinson's Disease and Sleep/Wake Disturbances

Parkinson s Disease ◽

10.1155/2012/205471 ◽

2012 ◽

Vol 2012 ◽

pp. 1-14 ◽

Cited By ~ 6

Author(s):

Todd J. Swick

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Sleep Disorders ◽

Sleep Disturbances ◽

Treatment Options ◽

Rem Sleep Behavior Disorder ◽

Behavior Disorder ◽

Clinical Aspects ◽

Nonmotor Symptoms ◽

Sleep Behavior

Parkinson's disease (PD) has traditionally been characterized by its cardinal motor symptoms of bradykinesia, rigidity, resting tremor, and postural instability. However, PD is increasingly being recognized as a multidimensional disease associated with myriad nonmotor symptoms including autonomic dysfunction, mood disorders, cognitive impairment, pain, gastrointestinal disturbance, impaired olfaction, psychosis, and sleep disorders. Sleep disturbances, which include sleep fragmentation, daytime somnolence, sleep-disordered breathing, restless legs syndrome (RLS), nightmares, and rapid eye movement (REM) sleep behavior disorder (RBD), are estimated to occur in 60% to 98% of patients with PD. For years nonmotor symptoms received little attention from clinicians and researchers, but now these symptoms are known to be significant predictors of morbidity in determining quality of life, costs of disease, and rates of institutionalization. A discussion of the clinical aspects, pathophysiology, evaluation techniques, and treatment options for the sleep disorders that are encountered with PD is presented.

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