scholarly journals Accuracy of the semantic fluency test to separate healthy old people from patients with Alzheimer’s disease in a low education population

2020 ◽  
Vol 69 (2) ◽  
pp. 82-87
Author(s):  
Tatiana Reis Fabiano Neves ◽  
Narahyana Bom de Araújo ◽  
Felipe de Oliveira Silva ◽  
José Vinícius Alves Ferreira ◽  
Thomas Rune Nielsen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diagnostic Accuracy ◽  
Verbal Fluency ◽  
Semantic Fluency ◽  
Semantic Verbal Fluency ◽  
Healthy Elderly ◽  
Significant Difference ◽  
Animal Category ◽  
Fluency Test

ABSTRACT Objective Evaluate the accuracy of two semantic categories of the verbal fluency test (supermarket and animal categories) to separate healthy elderly individuals and lower educated Alzheimer’s disease patients. Methods We evaluated 69 older adults with less than 5 years of schooling, consisting of 31 healthy elderly, and 38 patients diagnosed with Alzheimer’s disease. Semantic verbal fluency was evaluated using the animal and supermarket categories. Mann-Whitney U and Independent t Tests were used to compare the two groups, and the diagnostic accuracy of the tests was analyzed by sensitivity, specificity, likelihood ratio’s, and the Area Under the Curve (AUC). Results We found a significant difference between the healthy older and Alzheimer’s disease groups, in both, animal (p = 0.014) and supermarket verbal fluency (p < 0.001). The supermarket category showed better overall diagnostic accuracy (AUC = 0.840, 95% CI = 0.746-0.933; p < 0.001) compared to the animal category (AUC = 0.671, 95% CI = 0.543-0.800; p = 0.014). Conclusion The supermarket category of semantic verbal fluency provides better accuracy than the animal category for the identification of dementia in a Brazilian elderly population with low educational level.

Performance of healthy elderly with Alzheimer's disease at an early stage in executive function and language

2011 ◽  
Vol 26 (S2) ◽  
pp. 498-498
Author(s):  
M.T. Santos ◽  
G.C. Couto ◽  
J.C. Achieri ◽  
C.A. Júnior
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Stage ◽  
The Elderly ◽  
Screening Tests ◽  
Healthy Elderly ◽  
Initial Stage ◽  
Significant Difference ◽  
Common Causes ◽  
The Impact

Dementia are increasingly prevalent in population. The most common causes of dementia is Alzheimer's disease (AD). Screening tests have been used for the premature diagnosis of Alzheimer Disease (AD), specifically in the executive functions and language, which are compromised at an initial stage. However, the necessity standardized means and validated for our middle, to show oneself a pressing subject.ObjectiveTo analyze the impact of the length of sentences in the abstraction of proverbs in the Screening Test for Alzheimer's disease with Proverbs (TRDAP), healthy elderly and with Alzheimer's disease at early stage.MethodSurvey document in the database, analyzing the responses of the elderly (abstract or concrete interpretation of proverbs), relating the length of sentences (sayings) of stage B of TRDAP with the diagnosis of Alzheimer's disease and the interference of age and schooling.ResultsHealthy older people showed greater capacity for abstraction than those with AD. There was Significant differences, in the sayings 1 (p = 0.033) and 2 (p = 0.001), corresponding to lower sentences, which did not occur with the proverb 3. As for age no verified significant difference among the healthy and only saying 3 in AD patients, however schooling differenced the healthy.ConclusionElderly with Alzheimer's disease at an initial stage have lower performance in the comprehension of ambiguous sentences, interpretation and abstraction of proverbs, corroborating with the data of the literature. The size of these sentences appears to be inversely proportional to the correctness of interpretation in elderly patients with and without AD.

scholarly journals The Assessment of Visuospatial Skills and Verbal Fluency in the Diagnosis of Alzheimer’s Disease

2020 ◽  
Author(s):  
Andras Horvath ◽  
Dalida Berente ◽  
Anita Kamondi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Negative Correlation ◽  
Verbal Fluency ◽  
Disease Duration ◽  
Cognitive Domains ◽  
Diagnostic Potential ◽  
Intergroup Comparison ◽  
Significant Difference

Abstract Introduction: In the diagnosis of Alzheimer’s disease (AD), examining memory is predominant. Our aim was to analyse the potential role of various cognitive domains in the cognitive evaluation of AD. Methods: 52 individuals with AD underwent neuropsychological evaluation including Addenbrooke’s Cognitive Examination (ACE). Patients were selected in three groups based on disease duration in years (y) (Group 1: ≤2y n=15; Group 2: 2-4y n=26, Group 3: ≥4y n=11). Covariance weighted intergroup comparison was performed on global cognitive score and subscores of cognitive domains. Spearman’s rho was applied to study the correlation between cognitive subscores and disease duration. Results: Significant difference was found between ACE total scores among groups (χ2=16,03 p<0,001) with a high negative correlation (r= -0,54 p<0,001). With longer disease duration the visuospatial and memory subscores of ACE significantly decreased (χ2=28,36 p<0,001; and f=12,05 p<0,001 respectively). In the early phase of cognitive decline verbal fluency and memory were equally impaired (p>0.05). Visuospatial score showed strong negative correlation with disease duration (r:-0.73).Conclusion: Impairment of verbal fluency seems to have similar diagnostic potential in the early identification of Alzheimer’s disease as memory decline. Visuospatial assessment might be a good marker to monitor the progression of cognitive decline.

IC-P-155: Reduced frontal oxygenation during a verbal fluency test in patients suffering from Alzheimer's disease

2009 ◽  
Vol 5 (4S_Part_2) ◽  
pp. P62-P62
Author(s):  
Julia B.M. Langer ◽  
Martin Schecklmann ◽  
Thomas T. Polak ◽  
Christine Leonhard ◽  
Thomas Leitner ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Verbal Fluency ◽  
Verbal Fluency Test ◽  
Fluency Test

scholarly journals Elevated Angiopoietin-1 Serum Levels in Patients with Alzheimer’s Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Brigitte Schreitmüller ◽  
Thomas Leyhe ◽  
Elke Stransky ◽  
Niklas Köhler ◽  
Christoph Laske
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Serum Levels ◽  
Cognitive Status ◽  
Potential Candidate ◽  
Healthy Controls ◽  
Healthy Elderly ◽  
Significant Difference ◽  
Angiopoietin 1

Background. Alzheimer's disease (AD) is the most common cause of dementia in the elderly. AD is characterized by the accumulation of amyloid plaques and neurofibrillary tangles and by massive neuronal loss in the brain. There is epidemiologic and pathologic evidence that AD is associated with vascular risk factors and vascular diseases, contributing to cerebral hypoperfusion with consecutive stimulation of angiogenesis and upregulation of proangiogenic factors such as Angiopoietin-1 (Ang-1).Methods. In the present study, we measured Ang-1 serum levels in 42 patients with AD, 20 patients with mild cognitive impairment (MCI), and in 40 healthy elderly controls by ELISA.Results. We found significantly increased Ang-1 serum levels in patients with AD compared to control subjects(P=0.003). There was no significant difference between MCI patients and healthy controls(P=0.553)or between AD and MCI patients(P=0.054). The degree of cognitive impairment as measured by the mini-mental status examination (MMSE) score was significantly correlated with the Ang-1 serum levels in all patients and healthy controls.Conclusions. We found significantly increased Ang-1 serum levels in AD patients. We could also show an association between Ang-1 serum levels and the cognitive status in all patients and healthy controls. Thus, serum Ang-1 could be a potential candidate for a biomarker panel for AD diagnosis.

P3-271: Automated index of semantic verbal fluency in mild cognitive impairment and Alzheimer's disease

2012 ◽  
Vol 8 (4S_Part_15) ◽  
pp. P555-P555
Author(s):  
Serguei Pakhomov ◽  
Laura Hemmy ◽  
Michael Kuskowski ◽  
Rosebud Roberts ◽  
Ronald Petersen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Verbal Fluency ◽  
Semantic Verbal Fluency
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