scholarly journals Complete ¹H and 13C NMR assignments and anti fungal activity of two 8-hydroxy flavonoids in mixture

2007 ◽  
Vol 79 (2) ◽  
pp. 215-222 ◽  
Author(s):  
Susana Johann ◽  
Artur Smânia-Jr ◽  
Moacir G. Pizzolatti ◽  
Jan Schripsema ◽  
Raimundo Braz-Filho ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
13C Nmr ◽  
Nmr Assignments ◽  
Pathogenic Fungi ◽  
Two Dimensional ◽  
Chemical Shift Assignments ◽  
Commercial Sample ◽  
Nmr Techniques ◽  
13C Chemical Shift ◽  
Anti Fungal

A mixture of the two new flavonols 8-hydroxy-3, 4', 5, 6, 7-pentamethoxyflavone (1) and 8-hydroxy-3, 3', 4', 5, 6, 7-hexamethoxyflavone (2) was isolated from a commercial sample of Citrus aurantifolia. An array of one- (¹HNMR, {¹H}-13C NMR, and APT-13C NMR) and two-dimensional NMR techniques (COSY, NOESY, HMQC and HMBC) was used to achieve the structural elucidation and the complete ¹H and 13C chemical shift assignments of these natural compounds. In addition, the antifungal activity of these compounds against phytopathogenic and human pathogenic fungi was investigated.

ChemInform Abstract: Total Assignment of the 1H and 13C NMR Spectra of Benzo(f)(1) benzothieno(2,3-c)quinoline (I) by Inverse-Detected Two-Dimensional NMR Techniques.

ChemInform ◽  
2010 ◽  
Vol 23 (20) ◽  
pp. no-no
Author(s):  
J. P. SHOCKCOR ◽  
R. C. CROUCH ◽  
G. E. MARTIN ◽  
A. CHERIF ◽  
J.-K. LUO ◽  
...  
Keyword(s):  
13C Nmr ◽  
Nmr Spectra ◽  
13C Nmr Spectra ◽  
Two Dimensional ◽  
1H And 13C Nmr ◽  
Nmr Techniques

13C NMR Assignments of the Protonated Carbons of [d(TAGCGCTA)]2by Two-Dimensional Proton-Detected Heteronuclear Correlation

1988 ◽  
Vol 5 (5) ◽  
pp. 1089-1099 ◽  
Author(s):  
Steven R. LaPlante ◽  
Joseph Ashcroft ◽  
David Cowburn ◽  
George C. Levy ◽  
Philip N. Borer
Keyword(s):  
13C Nmr ◽  
Nmr Assignments ◽  
Two Dimensional ◽  
Heteronuclear Correlation

scholarly journals Steroidal Saponins from the Seeds of Hyoscyamus Niger L.

2008 ◽  
Vol 3 (1) ◽  
pp. 89-93
Author(s):  
Irina Lunga ◽  
Pavel Kintia ◽  
Stepan Shvets ◽  
Carla Bassarello ◽  
Sonia Piacente ◽  
...  
Keyword(s):  
13C Nmr ◽  
Chemical Shifts ◽  
Two Dimensional ◽  
Hyoscyamus Niger ◽  
Steroidal Saponins ◽  
1H And 13C Nmr ◽  
13C Nmr Chemical Shifts ◽  
Nmr Techniques ◽  
Pregnane Glycoside ◽  
First Time

Ten steroidal saponins have been isolated form the seeds of Hyoscyamus niger L. for the first time and their structures have been elucidated. Seven saponins belong to spirostane series, two are furostane-type and one is pregnane glycoside. Hyoscyamosides B, C and C2 are new steroidal saponins, which have never been reported before in literature. Complete assignments of the 1H and 13C NMR chemical shifts for all these glycosides were achieved by means of one- and two-dimensional NMR techniques, including 1H–1H COSY, HSQC, HMBC and ROESY spectra.

scholarly journals Synthesis and Bio-Evaluation of Natural Butenolides-Acrylate Conjugates

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1304 ◽  
Author(s):  
Longzhu Bao ◽  
Shuangshuang Wang ◽  
Di Song ◽  
Jingjing Wang ◽  
Xiufang Cao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Antifungal Activity ◽  
13C Nmr ◽  
Pathogenic Fungi ◽  
Phytopathogenic Fungi ◽  
Gibberella Zeae ◽  
Ionization Mass ◽  
Activity Screening ◽  
In Vitro Antifungal Activity

A series of novel 3-aryl-4-hydroxy-2(5H) furanone-acrylate hybrids were designed and synthesized based on the natural butenolides and acrylates scaffolds. The structures of the prepared compounds were characterized by 1H-NMR, 13C-NMR and electrospray ionization mass spectrometry (ESI-MS), and the bioactivity of the target compounds against twelve phytopathogenic fungi was investigated. The preliminary in vitro antifungal activity screening showed that most of the target compounds had moderate inhibition on various pathogenic fungi at the concentration of 100 mg·L−1, and presented broad-spectrum antifungal activities. Further studies also indicated that compounds 7e and 7k still showed some inhibitory activity against Pestallozzia theae, Sclerotinia sclerotiorum and Gibberella zeae on rape plants at lower concentrations, which could be optimized as a secondary lead for further research.

scholarly journals Steroidal Glycosides from the Seeds of Hyoscyamus Niger L. and their Antifungal Activity

2007 ◽  
Vol 2 (1) ◽  
pp. 108-113
Author(s):  
Irina Lunga ◽  
Pavel Chintea ◽  
Stepan Shvets ◽  
Anna Favelb ◽  
Cosimo Pizza
Keyword(s):  
Nmr Spectroscopy ◽  
Antifungal Activity ◽  
Pathogenic Fungi ◽  
Phytochemical Analysis ◽  
Two Dimensional ◽  
Hyoscyamus Niger ◽  
Steroidal Glycosides ◽  
Spirostanol Saponins ◽  
First Time

Phytochemical analysis of the seeds of Hyocyamus niger L. (Solonaceae) resulted in the isolation of six steroidal glycosides, two furostanol (1, 2) and four spirostanol saponins (3, 4, 5, 6), which were found in this plant for the first time. The structures of these compounds were determined by detailed analysis of their spectral data, including two-dimensional NMR spectroscopy and MS spectroscopy. The antifungal activity of a crude steroidal glycoside extract, fractions of spirostanoles and individual glicosides was investigated in vitro against a panel of human pathogenic fungi, yeasts as well as dermatophytes and filamentous species.

Sign in / Sign up

Export Citation Format

Share Document