scholarly journals Synthesis and Bio-Evaluation of Natural Butenolides-Acrylate Conjugates

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1304 ◽  
Author(s):  
Longzhu Bao ◽  
Shuangshuang Wang ◽  
Di Song ◽  
Jingjing Wang ◽  
Xiufang Cao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Antifungal Activity ◽  
13C Nmr ◽  
Pathogenic Fungi ◽  
Phytopathogenic Fungi ◽  
Gibberella Zeae ◽  
Ionization Mass ◽  
Activity Screening ◽  
In Vitro Antifungal Activity

A series of novel 3-aryl-4-hydroxy-2(5H) furanone-acrylate hybrids were designed and synthesized based on the natural butenolides and acrylates scaffolds. The structures of the prepared compounds were characterized by 1H-NMR, 13C-NMR and electrospray ionization mass spectrometry (ESI-MS), and the bioactivity of the target compounds against twelve phytopathogenic fungi was investigated. The preliminary in vitro antifungal activity screening showed that most of the target compounds had moderate inhibition on various pathogenic fungi at the concentration of 100 mg·L−1, and presented broad-spectrum antifungal activities. Further studies also indicated that compounds 7e and 7k still showed some inhibitory activity against Pestallozzia theae, Sclerotinia sclerotiorum and Gibberella zeae on rape plants at lower concentrations, which could be optimized as a secondary lead for further research.

scholarly journals Synthesis, In vitro Antifungal and Antitumour Activity of Some Triorganotin(IV) N,C,N-Chelates

2002 ◽  
Vol 9 (1-2) ◽  
pp. 91-96 ◽  
Author(s):  
Libor Dostál ◽  
Aleš Růžička ◽  
Roman Jambor ◽  
Vladimír Buchta ◽  
Petra Kubanová ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Antifungal Activity ◽  
Antitumour Activity ◽  
Ionization Mass ◽  
Clinical Use ◽  
The Novel ◽  
In Vitro Activity ◽  
Human Origin ◽  
In Vitro Antifungal Activity

The in vitro antifungal activity of compounds 1-3 ({[(CH3)2NCH2]2C6H3}R2SnX; (where X=Cl, R=n-Bu for 1, X=Br, R=n-Bu for 2 and x=PF6, R=n=Bu for 3)) was estimated with the help of a modified microdilution format of the M27-A guidelines and was compared with in vitro activity of their diphenyltin(IV) analogues 4 and 5 (where X=Br, R=Ph for 4 and X=PF6, R=Ph for 5), and of drugs currently in clinical use (ketoconazole, fluconazole and amphotericin B). It was found that in coordinating solvents the more soluble derivative 2 is less active than the phenyl one (4), and compounds 1 and 3 are even inactive.In this paper, the in vitro antitumour activity of ionic diphenyltin(IV) complexes 4 and 5 against seven tumoural cell lines of human origin is also reported. The preparation and characterization (H1, C13 and Sn119 NMR spectroscopy and electrospray ionization mass spectrometry) of the novel compound 3 is mentioned too.

scholarly journals Antifungal Activity of Semecarpus anacardium Linn. Oil against Four Phytopathogenic Fungi

2019 ◽  
Vol 2 (3) ◽  
pp. 42-44
Author(s):  
Aarti Patil ◽  
Sadat Quazi
Keyword(s):  
Antifungal Activity ◽  
Fungal Pathogens ◽  
Pathogenic Fungi ◽  
Phytopathogenic Fungi ◽  
Curvularia Lunata ◽  
Semecarpus Anacardium ◽  
Poisoned Food Technique ◽  
Almost All ◽  
In Vitro Antifungal Activity

The present study was undertaken to evaluate in-vitro antifungal activity of Semecarpus anacardium Linn. oil against four fungal pathogens, viz. Curvularia penniseti, Curvularia lunata, Fusarium oxysporum f. sp. ciceris and Helminthosporium maydis using poisoned food technique. The DMSO extract of S.anacardium oil was found to be more or less active against almost all tested pathogenic fungi with a varied spectrum of reduced growth. C.lunata has shown 93.3% inhibition and F.oxysporum and H.maydis have shown 94.4% inhibition and 100% mycelial inhibitions at 15% and 18% concentrations of the extract respectively. Whereas, C.penniseti was found to be quite sensitive that showed 88.9 inhibitions at 10% concentration but it showed 100% inhibition at 18% concentration.  

scholarly journals Rutaceae: conservation at Eka Karya Bali Botanic Garden and its in vitro antifungal activity screening

2021 ◽  
Vol 6 (2) ◽  
pp. 108
Author(s):  
I Putu Agus Hendra Wibawa ◽  
Arrohmatus Syafaqoh Li'aini ◽  
Putri Sri Andila ◽  
Frelyta Ainuz Zahro'
Keyword(s):  
Antifungal Activity ◽  
Methanolic Extract ◽  
Pathogenic Fungi ◽  
Inhibitory Effect ◽  
Diffusion Method ◽  
Botanic Garden ◽  
Murraya Paniculata ◽  
Activity Screening ◽  
In Vitro Antifungal Activity

Several species of Rutaceae have been widely used and commercialized in all regions in Indonesia. Some species of Rutaceae are consumed as fresh fruit and traditional medicine for various kinds of diseases, as well as to add aroma to various Indonesian culinary. Since 1959, Eka Karya Bali Botanic Garden (Eka Karya BBG) has successfully collected dozens of Rutaceae species with unknown potential. In addition to reporting the conservation of Rutaceae in Eka Karya BBG, this study aimed to screen the antifungal activity of Rutaceae methanolic extract toward Aspergillus niger, Cladosporium sp., and Fusarium solani. Leaves of 13 species of Rutaceae (Boenninghausenia sp., Citrus aurantifolia, C. maxima, C. medica, Clausena sp., Melicope sp., Micromelum sp., Murraya paniculata, Toddalia sp., Zanthoxylum sp., Z. alatum, Z. limonella, and Z. ovalifolium) were collected, cleaned, air-dried, soaked in methanol for three days, then evaporated using a rotary evaporator to obtain the plant crude extract. The in vitro inhibitory assay was conducted by the diffusion method. As a result, only C. medica, Clausena sp., and Z. limonella exhibited antifungal activity against those tested fungi. Their antifungal activity increased on day 2 post-treatment but slowly decreased on day 3. Thus, the result of this experiment can be used as preliminary data to researchRutaceae plant extracts as an alternative method to control pathogenic fungi. However, further research is needed to maintain and increase its inhibitory effect.

scholarly journals In Vitro Antifungal Activity of Sanguinarine and Chelerythrine Derivatives against Phytopathogenic Fungi

Molecules ◽  
2012 ◽  
Vol 17 (11) ◽  
pp. 13026-13035 ◽  
Author(s):  
Xin-Juan Yang ◽  
Fang Miao ◽  
Yao Yao ◽  
Fang-Jun Cao ◽  
Rui Yang ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Phytopathogenic Fungi ◽  
Sanguinarine And Chelerythrine ◽  
In Vitro Antifungal Activity

Design, Synthesis and Evaluate In Vitro Antifungal Activity of Novel Benzamide Derivatives

2019 ◽  
Vol 41 (3) ◽  
pp. 549-549
Author(s):  
Xuesong Wang and Xiaorong Tang Xuesong Wang and Xiaorong Tang
Keyword(s):  
Antifungal Activity ◽  
Pathogenic Fungi ◽  
Gibberella Zeae ◽  
Design Synthesis ◽  
Carboxylic Acid Amides ◽  
Almost All ◽  
Negative Controls ◽  
New Compounds ◽  
Benzamide Derivatives

A series of novel benzamide derivatives according to fluopicolide were designed and synthesized following the rule of combination carboxylic acid amides and amines derivatives together. The antifungal activity of the 15 new compounds were evaluated in vitro against five pathogenic fungi, including Sclerotinia sclerotiorum, Gibberella zeae, Rhizoctonia solani, Helminthosporium maydis and Botrytis cinerea. Almost all the structure have not been reported, except compounds 3, 5 and 6. A surprising finding is that all the five tested fungi breed faster than negative controls when supplementary with compound 715 , respectively.

Activity of Armillarisin B in vitro against Plant Pathogenic Fungi

2009 ◽  
Vol 64 (11-12) ◽  
pp. 790-792 ◽  
Author(s):  
Jin-Wen Shen ◽  
Bing-Ji Ma ◽  
Wen Li ◽  
Hai-You Yu ◽  
Ting-Ting Wu ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Methanolic Extract ◽  
Pathogenic Fungi ◽  
2D Nmr ◽  
Spectroscopic Studies ◽  
Gibberella Zeae ◽  
Plant Pathogenic Fungi ◽  
Fruiting Bodies ◽  
Bioassay Guided Fractionation

The methanolic extract of the fruiting bodies of the mushroom Armillariella tabescens was found to show antifungal activity against Gibberella zeae. The active compound was isolated from the fruiting bodies of A. tabescens by bioassay-guided fractionation of the extract and identifi ed as armillarisin B. Armillarisin B eventually corresponds to 2-hydroxy-2- phenylpropanediamide and its structure was confi rmed on the basis of spectroscopic studies including 2D NMR experiments.

scholarly journals In vitro Antifungal Activity of Plant Extracts, Hydrolates and Essential Oils of Some Medicinal Plants and Control of Cucumber Anthracnose

2019 ◽  
pp. 1-9
Author(s):  
Amanda P. Mattos ◽  
Fabricio P. Povh ◽  
Bruna B. Rissato ◽  
Vítor V. Schwan ◽  
Kátia R. F. Schwan-Estrada
Keyword(s):  
Antifungal Activity ◽  
Medicinal Plants ◽  
Curcuma Longa ◽  
Sclerotium Rolfsii ◽  
Phytopathogenic Fungi ◽  
In Vivo Test ◽  
Activity Effect ◽  
In Vitro Antifungal Activity

Aims: This study is aimed to evaluate the in vitro antifungal activity effect of the crude aqueous extract (CAE), hydrolate (HY) and essential oil (EO) of Corymbia citriodora, Cymbopogon citratus, Cymbopogon flexuosus and Curcuma longa against the phytopathogenic fungi Alternaria steviae, Botryosphaeria dothidea, Colletotrichum gloeosporioides and Sclerotium rolfsii, and assess, in situ, the effectiveness of CAE of medicinal plants in reducing the severity of the cucumber anthracnose. Methodology: The EOs and HYs were obtained by hydrodistillation. The CAEs were prepared by the turbolysis method. Mycelial growth of the fungi was measured daily, by the diametrically opposite method. In the in vivo test, the CAEs were sprayed on the cotyledon leaves of healthy cucumber plants with three days after were inoculated with C. lagenarium. The severity of assessment of the disease was based on a scale of notes. Results: The medicinal plants studied showed antifungal activity against all or almost all pathogens. In general, treatment with CAE and HY of C. longa revealed the highest inhibition against the fungi tested. With the exception of the EO of C. longa, the other EOs showed total inhibition against all the fungi and in all the concentrations tested. Compared to control, in in vivo assays CAE of C. citratus presents a potential for control of cucumber anthracnose reducing the severity of the disease. Conclusion: The medicinal plants studied produce compounds associated with antimicrobial activity.

scholarly journals Facile synthesis and antifungal activity of dithiocarbamate derivatives bearing an amide moiety

2015 ◽  
Vol 80 (11) ◽  
pp. 1367-1374 ◽  
Author(s):  
Yu-Wen Li ◽  
Shu-Tao Li
Keyword(s):  
Antifungal Activity ◽  
Fusarium Solani ◽  
High Resolution Mass Spectrometry ◽  
Alternaria Solani ◽  
Phytopathogenic Fungi ◽  
Gibberella Zeae ◽  
Significant Activity ◽  
Facile Synthesis ◽  
Dithiocarbamate Derivatives

A series of novel dithiocarbamate derivatives bearing amide moiety 3a-3i and 4a-4i were synthesized by a facile method, and the structures of these derivatives were confirmed by 1H NMR, 13C NMR, elemental analysis and high-resolution mass spectrometry (HRMS). Their antifungal activity against five phytopathogenic fungi were evaluated, and the results showed that most of the target compounds displayed low antifungal activity in vitro against Gibberella zeae, Cytospora sp., Collectotrichum gloeosporioides, Alternaria solani, and Fusarium solani at concentration of 100 mg/L. Compound 4f and 4g exhibited significant activity against Alternaria solani and Collectotrichum gloeosporioides, respectively.

scholarly journals Chemical Composition and Antifungal Activity of the Essential Oil of Cotinus coggygria from Marche Region (Italy)

2018 ◽  
Vol 13 (9) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Daniele Fraternale ◽  
Donata Ricci
Keyword(s):  
Antifungal Activity ◽  
Essential Oil ◽  
Pathogenic Fungi ◽  
Gas Chromatography Mass Spectrometry ◽  
Dilution Method ◽  
Agar Dilution Method ◽  
Plant Pathogenic Fungi ◽  
Cotinus Coggygria ◽  
In Vitro Antifungal Activity

The present study reports the results of gas chromatography-mass spectrometry (GC/MS) analyses of the essential oil from flowering aerial parts of Cotinus coggygria Scoop. (Anacardiaceae), as well as its in vitro antifungal activity against nine plant pathogenic fungi. Moreover, the essential oil was evaluated for its antifungal activity using the agar dilution method, and also MICs (minimum inhibitory concentrations) and MFCs (minimum fungicidal concentrations) were determined. The major compounds identified by GC-MS were limonene (49.2%), (Z)-β-ocimene (13.6%), α-pinene (8.8%) and (E)-β-ocimene (5.9%). The oil showed in vitro antifungal activity against some species of the Fusarium genus, Botrytis cinerea, and Alternaria solani. Our study indicates that the oil of C. coggygria could be used as a control agent for plant pathogenic fungi in natural formulations.

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