scholarly journals DOES THE RHEUMATOID ARTHRITIS AFFECT THE ENTERIC NERVOUS SYSTEM?

2019 ◽  
Vol 56 (2) ◽  
pp. 113-117
Author(s):  
Jacqueline Nelisis ZANONI ◽  
Gleison Daion PIOVEZANA BOSSOLANI
Keyword(s):  
Rheumatoid Arthritis ◽  
Nervous System ◽  
Enteric Nervous System ◽  
Negative Impact ◽  
Single Injection ◽  
Control Group ◽  
Morphometric Analyses ◽  
Whole Mount ◽  
System Objective ◽  
Induce Arthritis

ABSTRACT BACKGROUND: Few studies regarding arthritic diseases have been performed to verify the presence of the neurodegeneration. Given the increased oxidative stress and extra-articular effects of the rheumatoid arthritis, the gastrointestinal studies should be further investigated aiming a better understanding of the systemic effects the disease on enteric nervous system. OBJECTIVE: To determine whether the rheumatoid arthritis affects the nitrergic density and somatic area of the nNOS- immunoreactive (IR) myenteric neurons, as well as the morphometric areas of CGRP and VIP-IR varicosities of the ileum of arthritic rats. METHODS: Twenty 58-day-old male Holtzmann rats were distributed in two groups: control and arthritic. The arthritic group received a single injection of the Freund’s Complete Adjuvant in order to induce arthritis model. The whole-mount preparations of ileum were processed for immunohistochemistry to VIP, CGRP and nNOS. Quantification was used for the nitrergic neurons and morphometric analyses were performed for the three markers. RESULTS: The arthritic disease induced a reduction 6% in ileal area compared to control group. No significant differences were observed in nitrergic density comparing both groups. However, arthritic group yielded a reduction of the nitrergic neuronal somatic area and VIP-IR varicosity areas. However, an increase of varicosity CGRP-IR areas was also observed. CONCLUSION: Despite arthritis resulted in no alterations in the number of nitrergic neurons, the retraction of ileal area and reduction of nitrergic somatic and VIP-IR varicosity areas may suggest a negative impact the disease on the ENS.

scholarly journals Intricate Estimation and Evaluation of Mandibular Movements in Geriatric Patients Suffering from Rheumatoid Arthritis

2017 ◽  
Vol 18 (9) ◽  
pp. 781-784
Author(s):  
Shruti Dev ◽  
Sonali Perti ◽  
Mirna Garhnayak ◽  
Kalinga K Sahoo ◽  
Angurbala Dhal ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Geriatric Patients ◽  
Negative Impact ◽  
Autoimmune Disorder ◽  
Opening Angle ◽  
Control Group ◽  
Mandibular Movement ◽  
Edentulous Patients ◽  
Mandibular Movements ◽  
And Control

ABSTRACT Background Rheumatoid arthritis (RA) is an autoimmune disorder that usually affects joints and making them warm, painful, and swollen. The chief purpose of this study was to evaluate movements of mandible in geriatric patients suffering from RA with or without temporomandibular joint dysfunction. Materials and methods A total of 45 people were included in this study with age of 60 years and above. Partially or completely edentulous patients were divided into experimental and control group. Experimental group consists of 20 people suffering from arthritis and control group consists of 25 people without arthritis. Movements were recorded with or without prosthesis while mastication in both experimental and control group. Results Statistical evaluation of two studied groups showed decrease opening angle (p < 0.05) during mastication; however, insertion of new prosthesis showd a significant increase in values in both groups, with an increase in opening and closing angles. Conclusion Positive correlation was found between arthritis and movements of the mandible in older people suffering from RA. Clinical significance Patients suffering from RA are having restricted mandibular movements thus imposing an overall negative impact however; presence of prosthesis has been shown to enforce a positive effect on mandibular movement. How to cite this article Dev S, Perti S, Garhnayak M, Sahoo KK, Dhal A, Garhnayak L. Intricate Estimation and Evaluation of Mandibular Movements in Geriatric Patients Suffering from Rheumatoid Arthritis. J Contemp Dent Pract 2017;18(9):781-784.

Abnormalities of the enteric nervous system in homozygous and heterozygous endothelin B-receptor deficient rats revealed by whole mount immunohistochemistry

2001 ◽  
Vol 120 (5) ◽  
pp. A333
Author(s):  
Heinz-Juergen Krammer ◽  
Christoph Dembowski ◽  
Georg B.T. Von Boyen ◽  
Hannelore Ehrenreich ◽  
Manfred V. Singer ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Endothelin B Receptor ◽  
Whole Mount ◽  
Endothelin B

scholarly journals The mild cranial traumas and autoimmune affection of the nervous system: dynamic of the indexes of the B-cells activation in patients during the rehabilitation period

2008 ◽  
Vol 7 (5-2) ◽  
pp. 486-489
Author(s):  
F. A. Yusupov ◽  
S. A. Groshev ◽  
U. A. Karimov
Keyword(s):  
Rheumatoid Arthritis ◽  
Nervous System ◽  
B Cells ◽  
B Lymphocytes ◽  
Nervous Tissue ◽  
Standard Treatment ◽  
Control Group ◽  
Neurological Signs ◽  
Rehabilitation Period ◽  
Definition Of

The aim was to study the indexes of the autoimmune affection of the nervous system in patients with rheumatoid arthritis (RA) after mild cranial traumas (CT). Under the observation there were 16 patients with neurological signs of RA, got mild CT. The group of compare consisted of 30 patients with RA and the nervous system lesions but without CT in the histories of lives. 30 healthy people were in the control group. The blood for the investigations was got 6 times from patients of the main group: on the 2nd, 15th, 30th, 60th, 90th, and 120th days after the CT. The autoimmune affection of the nervous system was diagnosed by the help of definition of the cerebrolysin-dependent activation of the B-lymphocytes by the method of quantitive cytophluorimetry. It was found that B-cells of RA patients with the nervous system lesions were sensitized to the nervous tissue. Even mild CT of the RA patients noticeably raises the activity of the immune system pointed on the tissue of the CNS. Usage of the standard treatment could not prevent such changes which were the brightest to the 15th day after CT.

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