scholarly journals Locally advanced colorectal cancer: results of surgical treatment and prognostic factors

2011 ◽  
Vol 48 (4) ◽  
pp. 270-275 ◽  
Author(s):  
Fábio Guilherme Campos ◽  
Maria Célia Calijuri-Hamra ◽  
Antonio Rocco Imperiale ◽  
Desidério Roberto Kiss ◽  
Sergio Carlos Nahas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Advanced Colorectal Cancer ◽  
Locally Advanced ◽  
Survival Rates ◽  
Recurrence Rates ◽  
Free Survival ◽  
Histological Data ◽  
Locally Advanced Colorectal Cancer ◽  
Colorectal Cancer Patients

OBJECTIVES: To evaluate the incidence surgical results and prognostic factors of locally advanced colorectal cancer. METHODS: Cohort study including 679 colorectal cancer patients treated from 1997 to 2007. Clinical, surgical and histological data were analyzed. RESULTS: Ninety patients (females 61%; median age 59 years) were treated for locally advanced carcinomas (13.2%), either in the colon (66%) or rectum (34%). Extended resections most commonly involved the small bowel (19.8%), bladder (16.4%), uterus (12.9%) and ovaries (11.2%). Postoperative morbidity and mortality occurred in 23 (25.6%) and 3 (3.3%) patients, respectively. Survival and recurrence analysis among 76 R0 (84.4%) procedures revealed a 60% 5-year survival and 34% local recurrence rates. Survival curves demonstrated reduced rates for rectal location (45% vs 65%), tumor depth (50% for T4 vs 75% for T3), vascular/ lymphatic/perineural invasion (35% vs 80%) and lymph node metastasis (35% vs 80%). CONCLUSIONS: Locally advanced carcinomas were found in 13.2% of patients. Survival rates were negatively affected by rectal location and adverse histological features. Number of involved organs and neoplastic adhesions did not influenced chances of survival. A radical R0 extended resection was achieved in a high proportion of cases, resulting in a 60% cancer-free survival under acceptable operative risks.

scholarly journals Prognostic Factors for Post-Recurrence Survival in Stage II and III Colorectal Carcinoma Patients

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1108
Author(s):  
Neda Nikolic ◽  
Davorin Radosavljevic ◽  
Dusica Gavrilovic ◽  
Vladimir Nikolic ◽  
Nemanja Stanic ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
High Risk ◽  
Advanced Colorectal Cancer ◽  
Locally Advanced ◽  
Disease Recurrence ◽  
Stage Ii ◽  
Stage Iii ◽  
Locally Advanced Colorectal Cancer ◽  
Stage Ii Colorectal Cancer

Background and objectives: This study aimed to evaluate prognostic factors for post-recurrence survival in local and locally advanced colorectal cancer patients. Materials and Methods: A total of 273 patients with stage III and high-risk stage II colorectal cancer were prospectively enrolled. All patients underwent operative treatment of the primary tumor and adjuvant fluorouracil-based chemotherapy. Results: Over the three-year period (2008–2010), a cohort of 273 patients with stage III and high-risk stage II colorectal cancer had been screened. During follow up, 105 (38.5%) patients had disease recurrence. Survival rates 1-, 3- and 5-year after recurrence were 53.9, 18.2 and 6.5%, respectively, and the median post-recurrence survival time was 13 months. Survival analysis showed that age at diagnosis (p < 0.01), gender (p < 0.05), elevated postoperative Ca19-9 (p < 0.01), tumor histology (adenocarcinoma vs. mucinous vs. signet ring tumors, p < 0.01) and tumor stage (II vs. III, p < 0.05) had a significant influence on post-recurrence survival. Recurrence interval and metastatic site were not related to survival following recurrence. Multivariate analysis showed that older age (HR 2.43), mucinous tumors (HR 1.51) and tumors expressing Ca19-9 at baseline (HR 3.51) were independently associated with survival following recurrence. Conclusions: Baseline patient and tumor characteristics largely predicted patient outcomes after disease recurrence. Recurrence intervals in local and locally advanced colorectal cancer were not found to be prognostic factors for post-recurrence survival. Older age, male gender, stage III and mucinous histology were poor prognostic factors after the disease had recurred. Stage II patients had remarkable post-recurrence survival compared to stage III patients.

EXPERIENCE OF THE APPLICATION OF THERMOCHEMIORRADIOTHERAPY IN COMBINED TREATMENT OF DYSTAL CANCER OF DIRECT INTESTINE

2019 ◽  
Vol 65 (1) ◽  
pp. 131-134
Author(s):  
Zhanna Startseva ◽  
Sergey Afanasev ◽  
Dina Plaskeeva
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Primary Tumor ◽  
Advanced Colorectal Cancer ◽  
Combined Treatment ◽  
Locally Advanced ◽  
Chemoradiation Therapy ◽  
Locally Advanced Colorectal Cancer

The article describes the experience of using ther-mochioradiotherapy in the combined treatment of distal locally advanced colorectal cancer, as well as comparing the effectiveness of treatment with chemoradiation therapy. The use of the proposed method as a component of the combined treatment of patients with rectal cancer allowed to increase the percentage of organ-preserving operations. As a result of thermochemotherapy, the prevalence of the primary tumor was significantly reduced, as a result of which the number of sphincter-bearing operations was reduced by almost 2 times (p

Extended resections are beneficial for patients with locally advanced colorectal cancer

1995 ◽  
Vol 38 (12) ◽  
pp. 1251-1256 ◽  
Author(s):  
J. R. Izbicki ◽  
S. B. Hosch ◽  
W. T. Knoefel ◽  
B. Passlick ◽  
C. Bloechle ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Advanced Colorectal Cancer ◽  
Locally Advanced ◽  
Locally Advanced Colorectal Cancer

scholarly journals First-line treatment with modified FOLFOXIRI plus bevacizumab in patients with locally advanced colorectal cancer

2020 ◽  
Vol 28 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Yasufumi Yamada ◽  
Kazuhiko Yoshimatsu ◽  
Hajime Yokomizo ◽  
Sachiyo Okayama ◽  
Hiroyuki Maeda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Advanced Colorectal Cancer ◽  
Locally Advanced ◽  
Line Treatment ◽  
First Line ◽  
Locally Advanced Colorectal Cancer ◽  
First Line Treatment
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