LOW BONE MINERAL DENSITY IN BRAZILIAN PATIENTS AT DIAGNOSIS OF CELIAC DISEASE

BackgroundLow bone mineral density is considered an extra-intestinal manifestation of celiac disease with reduced bone mass, increased bone fragility, and risk of fractures. Celiac disease is considered a condition at high risk for secondary osteoporosis and the evaluation of bone density is very important in the clinical management of these patients.ObjectiveThe present study aimed to investigate bone alterations in celiac patients from Curitiba, South Region of Brazil at diagnosis, correlating the findings with age and gender.MethodsPatients who were included in the study were attended to in a private office of the same physician from January 2009 to December 2013. The diagnosis of celiac disease was done through clinical, serological and histological findings. All data were collected from the medical charts of the patients. After the diagnosis of celiac disease, evaluation for low bone mineral density was requested by dual-energy X-ray absorptiometry (DEXA). DEXA bone densitometer was used to estimate low bone mineral density at the lumbar spine and femur.ResultsA total of 101 patients, 82 (81.2%) female and 19 (18.8%) male subjects, with mean age of 39.0±3.03 years were included. At celiac disease diagnosis, 36 (35.6%) were younger than 30 years, 41 (40.6%) were between 31 and 50 years, and 24 (23.8%) were older than 50 years. Among the evaluated patients, 69 (68.3%) presented low bone mineral density, being 47% with osteopenia and 32% with osteoporosis. Patients who were older than 51 years and diagnosed with celiac disease presented low bone mineral density in 83.3% (20/24) of the cases. As expected, age influenced significantly the low bone mineral density findings. Among women, low bone mineral density was present with high frequency (60%) from 30 to 50 years. In patients diagnosed older than 60 years (n=8), all the women (n=5) and two of the three men had osteoporosis.ConclusionThis study demonstrated that 69% of Brazilian patients with celiac disease at diagnosis had low bone mineral density, being more frequent in women older than 50 years.

Download Full-text

P.06.8 SERUM 25-HYDROXYCHOLECALCIFEROL LEVELS AT CELIAC DISEASE DIAGNOSIS PREDICT BONE MINERAL DENSITY RECOVERY AFTER GLUTEN EXCLUSION

Digestive and Liver Disease ◽

10.1016/s1590-8658(16)30213-4 ◽

2016 ◽

Vol 48 ◽

pp. e155-e156

Author(s):

K. Efthymakis ◽

M. Serio ◽

R. Sanelli ◽

A. Milano ◽

F. Laterza ◽

...

Keyword(s):

Bone Mineral Density ◽

Celiac Disease ◽

Bone Mineral ◽

Disease Diagnosis ◽

Mineral Density ◽

Celiac Disease Diagnosis ◽

25 Hydroxycholecalciferol

Download Full-text

Predictors of improvement in bone mineral density after celiac disease diagnosis

Endocrine ◽

10.1007/s12020-017-1488-x ◽

2017 ◽

Vol 59 (2) ◽

pp. 311-318 ◽

Cited By ~ 6

Author(s):

Haley M. Zylberberg ◽

Benjamin Lebwohl ◽

Arindam RoyChoudhury ◽

Marcella D. Walker ◽

Peter H. R. Green

Keyword(s):

Bone Mineral Density ◽

Celiac Disease ◽

Bone Mineral ◽

Disease Diagnosis ◽

Mineral Density ◽

Celiac Disease Diagnosis

Download Full-text

Prevalence of low bone mineral density in children and adolescents with celiac disease under treatment

Sao Paulo Medical Journal ◽

10.1590/s1516-31802009000500006 ◽

2009 ◽

Vol 127 (5) ◽

pp. 278-282 ◽

Cited By ~ 14

Author(s):

Maria Eugênia Farias Almeida Motta ◽

Maria Eduarda Nóbrega de Faria ◽

Gisélia Alves Pontes da Silva

Keyword(s):

Bone Mineral Density ◽

Celiac Disease ◽

Lumbar Spine ◽

Bone Mineral ◽

Gluten Free Diet ◽

Whole Body ◽

Chronological Age ◽

Gluten Free ◽

Mineral Density ◽

Low Bone Mineral Density

CONTEXT AND OBJECTIVE: Low bone mineral density may be a finding among children and adolescents with celiac disease, including those undergoing treatment with a gluten-free diet, but the data are contradictory. The aim of this study was to determine the frequency of bone mineral density abnormalities in patients on a gluten-free diet, considering age at diagnosis and duration of dietary treatment. DESIGN AND SETTING: Cross-sectional prevalence study at the Pediatric Gastroenterology Outpatient Clinic of Instituto Materno Infantil Professor Fernando Figueira. METHODS: Thirty-one patients over five years of age with celiac disease and on a gluten-free diet were enrolled. Bone mineral density (in g/cm²) was measured in the lumbar spine and whole body using bone densitometry and categorized using the criteria of the International Society for Clinical Densitometry, i.e. low bone mineral density for chronological age < -2.0 Z-scores. Age at diagnosis and duration of dietary treatment were confirmed according to the date of starting the gluten-free diet. RESULTS: Low bone density for chronological age was present in 3/31 patients in the lumbar spine and 1/31 in the whole body (also with lumbar spine abnormality). At diagnosis, three patients with low bone mineral density for the chronological age were more than 7.6 years old. These patients had been on a gluten-free diet for six and seven months and 3.4 years. CONCLUSION: Pediatric patients with celiac disease on long-term treatment are at risk of low bone mineral density. Early diagnosis and long periods of gluten-free diet are directly implicated in bone density normalization.

Download Full-text

Low bone mineral density on DXA and slipped capital femoral epiphysis as rare presentation in a child with Rubinstein-Taybi syndrome

BMJ Case Reports ◽

10.1136/bcr-2021-242349 ◽

2021 ◽

Vol 14 (8) ◽

pp. e242349

Author(s):

Madhura Bharat Karguppikar ◽

Nikhil Shah ◽

Vaman Khadilkar ◽

Anuradha Khadilkar

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Slipped Capital Femoral Epiphysis ◽

Minor Trauma ◽

Implant Fixation ◽

Mineral Density ◽

Rare Presentation ◽

Dxa Scan ◽

X Ray ◽

Low Bone Mineral Density

We present a 7-year-old girl with Rubinstein-Taybi syndrome (RTS) and slipped capital femoral epiphysis (SCFE). She underwent bilateral arthroscopy with implant fixation for the SCFE and the symptoms resolved. This was followed by fracture of the femur after minor trauma. Dual energy X-ray absorptiometry (DXA) scan done to evaluate her bone health revealed a low bone mineral density (BMD). Our case highlights the finding of low BMD on DXA and rare association of SCFE in a child with RTS. The conundrum in this case is whether this child can be labelled to have osteoporosis as defined by the criteria given by the International Society for Clinical Densitometry guidelines.

Download Full-text

Does Quantitative Tibial Ultrasound Predict Low Bone Mineral Density Defined by Dual Energy X-Ray Absorptiometry?

Yonsei Medical Journal ◽

10.3349/ymj.2008.49.3.436 ◽

2008 ◽

Vol 49 (3) ◽

pp. 436 ◽

Cited By ~ 14

Author(s):

Hakan Tuna ◽

Murat Birtane ◽

Galip Ekuklu ◽

Fikret Cermik ◽

Filiz Tuna ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Dual Energy ◽

Mineral Density ◽

X Ray ◽

Low Bone Mineral Density

Download Full-text

Dual Energy X-Ray Absorptiometry in Small Rats with Low Bone Mineral Density

Calcified Tissue International ◽

10.1007/s002230001176 ◽

2000 ◽

Vol 67 (6) ◽

pp. 455-459 ◽

Cited By ~ 4

Author(s):

M. M. Petersen ◽

P. K. Nielsen ◽

E. Lewin ◽

K. Olgaard

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Dual Energy ◽

Mineral Density ◽

X Ray ◽

Low Bone Mineral Density

Download Full-text

The Prevalence of Disordered Eating, Menstrual Dysfunction, and Low Bone Mineral Density among US Collegiate Athletes

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.16.1.1 ◽

2006 ◽

Vol 16 (1) ◽

pp. 1-23 ◽

Cited By ~ 109

Author(s):

Katherine A. Beals ◽

Amanda K. Hill

Keyword(s):

Bone Mineral Density ◽

Disordered Eating ◽

Bone Mineral ◽

Collegiate Athletes ◽

Z Score ◽

Mineral Density ◽

Menstrual Dysfunction ◽

X Ray ◽

Low Bone Mineral Density ◽

Menstrual History

The purpose of this study was to examine the prevalence of disordered eating (DE), menstrual dysfunction (MD), and low bone mineral density (BMD) among US collegiate athletes (n = 112) representing 7 different sports (diving, swimming, x-country, track, tennis, field hockey, and softball) and determine differences in prevalence existed between athletes participating in lean-build (LB) and non-lean build (NLB) sports. DE and MD were assessed by a health, weight, dieting, and menstrual history questionnaire. Spinal BMD was determined via dual energy x-ray absorptiometry. Twenty-eight athletes met the criteria for DE, twenty-nine for MD, and two athletes had low BMDs (using a Z score below −2.0). Ten athletes met the criteria for two disorders (one with disordered eating and low BMD and nine with disordered eating and menstrual dysfunction), while only one athlete met the criteria for all three disorders. Using a Z score below −1.0, two additional athletes met the criteria for all three disorders and three more athletes met the criteria for a combination of two disorders. With the exception of MD, which was significantly more prevalent among LB vs. NLB sports (P = 0.053), there were no differences between the groups in the prevalence of individual disorders or combinations of disorders. These data indicate that the combined prevalence of DE, MD, and low BMD among collegiate athletes is small; however, a significant number suffer from individual disorders of the Triad.

Download Full-text