Demonstration of antibody and cellular immune response to brain extract in West and Lennox-Gastaut syndromes

We investigated humoral and cellular immune response to brain tissues in 15 patients with West syndrome, in 9 patients with Lennox-Gastaut syndrome and in 20 healthy children. High levels of a precipitating antibody to a saline extract of brain tissue were detected in all patients; leucocyte migration inhibition test with the same antigen was found to be positive in most of them. The role of this autoimmune response in the pathogenesis of West and Lennox-Gastaut syndromes remains to the elucidated.

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Healing and adverse remodelling after acute myocardial infarction: role of the cellular immune response

Heart ◽

10.1136/heartjnl-2012-301623 ◽

2012 ◽

Vol 98 (18) ◽

pp. 1384-1390 ◽

Cited By ~ 46

Author(s):

Anja M van der Laan ◽

Matthias Nahrendorf ◽

Jan J Piek

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Immune Response ◽

Cellular Immune Response ◽

Cellular Immune

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Cellular Immune Response to Viruses and the Biological Role of Polymorphic Major Transplantation Antigens

Comprehensive Virology ◽

10.1007/978-1-4613-3009-7_4 ◽

1979 ◽

pp. 171-204 ◽

Cited By ~ 5

Author(s):

R. M. Zinkernagel

Keyword(s):

Immune Response ◽

Cellular Immune Response ◽

Biological Role ◽

Cellular Immune ◽

Transplantation Antigens

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CMV-Specific Immune Response—New Patients, New Insight: Central Role of Specific IgG during Infancy and Long-Lasting Immune Deficiency after Allogenic Stem Cell Transplantation

International Journal of Molecular Sciences ◽

10.3390/ijms20020271 ◽

2019 ◽

Vol 20 (2) ◽

pp. 271 ◽

Cited By ~ 3

Author(s):

Przemyslaw Zdziarski

Keyword(s):

Immune Response ◽

Nk Cells ◽

Cellular Immune Response ◽

Specific Immune Response ◽

Primary Immune Response ◽

Virus Reactivation ◽

Allogenic Stem Cell Transplantation ◽

Specific Igg ◽

Cellular Immune

Although the existing paradigm states that cytomegalovirus (CMV) reactivation is under the control of the cellular immune response, the role of humoral and innate counterparts are underestimated. The study analyzed the host–virus interaction i.e., CMV-immune response evolution during infection in three different clinical situations: (1) immunodeficient CMV-positive human leukocyte antigen (HLA)-matched bone marrow recipients after immunoablative conditioning as well as immunocompetent, (2) adult, and (3) infant with primary immune response. In the first situation, a fast and significant decrease of specific immunity was observed but reconstitution of marrow-derived B and natural killer (NK) cells was observed prior to thymic origin of T cells. The lowest CMV-IgG (93.2 RU/mL) was found just before CMV viremia. It is noteworthy that the sole and exclusive factor of CMV-specific immune response is a residual recipient antibody class IgG. The CMV-quantiferon increase was detected later, but in the first phase, phytohemagglutinin (PHA)-induced IFN-γ release was significantly lower than that of CMV-induced (“indeterminate” results). It corresponds with the increase of NK cells at the top of lymphocyte reconstitution and undetected CMV-specific CD8 cells using a pentamer technique. In immunocompetent adult (CMV-negative donor), the cellular and humoral immune response increased in a parallel manner, but symptoms of CMV mononucleosis persisted until the increase of specific IgG. During infancy, the decrease of the maternal CMV-IgG level to 89.08 RU/mL followed by clinical sequel, i.e., CMV replication, were described. My observations shed light on a unique host-CMV interaction and CMV-IgG role: they indicate that its significant decrease predicts CMV replication. Before primary cellular immune response development, the high level of residual CMV-IgG (about >100 R/mL) from mother or recipient prevents virus reactivation. The innate immune response and NK-dependent IFN-secretion should be further investigated.

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