scholarly journals Combined nerve conduction index in diabetic polyneuropathy

2012 ◽  
Vol 70 (5) ◽  
pp. 330-334 ◽  
Author(s):  
Carlos Otto Heise ◽  
Flavia Costa Nunes Machado ◽  
Simone Consuelo de Amorim ◽  
Sonia Maria de Toledo
Keyword(s):  
Nerve Conduction ◽  
Diabetic Polyneuropathy ◽  
Nerve Conduction Studies ◽  
The Other ◽  
Diabetic Patients ◽  
Lumbosacral Radiculopathy ◽  
Standard Deviations ◽  
Higher Sensitivity

Diabetic polyneuropathy can be confirmed by nerve conduction studies. The data can be analyzed in the form of a combined index instead of individual parameters. METHODS: The combined index included five parameters of nerve conduction studies commonly used for evaluation of polyneuropathies. We evaluated sensitivity in 100 diabetic patients with suspected polyneuropathy, and specificity in 200 non-diabetic patients with suspected lumbosacral radiculopathy. All results were expressed in number of standard deviations (SD). RESULTS: The sensitivity of the combined index was 81 or 74%, and specificity was 97 or 98%, using respectively -2.0 or -2.5 SD as cutoff. The range of sensitivity of the other parameters was 57-65% or 48-56%, and specificity range was 96-98% or 98-100%, using the same criteria. DISCUSSION: The combined index had higher sensitivity and equivalent specificity compared to isolated parameters.

Glycemic Control and Clinico-Electrophysiological Severity of Diabetic Polyneuropathy

2019 ◽  
Vol 5 (2) ◽  
pp. 177-184
Author(s):  
KM Nazmul Islam Joy ◽  
ATM Hasibul Hasan ◽  
Md Rafiqul Islam ◽  
Farhana Kalam ◽  
M Lutful Kabir ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Diabetic Neuropathy ◽  
Nerve Conduction ◽  
Scoring System ◽  
Diabetic Polyneuropathy ◽  
Nerve Conduction Studies ◽  
Clinical Severity ◽  
Diabetic Patients ◽  
Motor Neuropathy ◽  
Clinical Scoring

Background: Diabetic polyneuropathy (DPN) has a significant positive correlation with poor glycemic control (HbA1c ≥7%). The clinical, biochemical and electrophysiological parameters of DPN in Bangladeshi citizens have not yet been explored elaborately Objective: The purpose of the study was to detect and categorize status of glycemic control of Bangladeshi people and to analyze its impact on clinical severity of DPN using Toronto Clinical Scoring System (TCSS) and electrophysiological severity by modified Michigan diabetic neuropathy score (MDNS). Methodology: This observational study was carried out on diabetic patients having probable DPN by purposive sampling, attending Neurology OPD of Dhaka Medical College Hospital, Dhaka, Bangladesh and Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine & Metabolic Disorder (BIRDEM) Hospital, Dhaka, Bangladesh from July 2014 to June 2016. Clinical parameters were recorded and DPN was graded as “no neuropathy”, “mild”, “moderate” and “severe” neuropathy by the Toronto Clinical Scoring System (TCSS). A standard nerve conduction study was performed on each patient and electrophysiological grading according to modified Michigan diabetic neuropathy score (MDNS) was done. Diabetic status of patients was classified into “controlled” (HbA1c <7.0%) and “uncontrolled” (HbA1c ≥7.0%) groups and HbA1c level and the clinical & electrophysiological severity scores were compared and were analyzed. Results: Mean age of the patients was 57.2±9.37 years. 51.0% cases were males and 49% cases were females. The mean HbA1c in the study population was 7.6±0.94% and 56.0% patients had HbA1c≥ 7% .Motor nerve conduction studies revealed that both CMAP amplitudes and MNCV in the ulnar, peroneal and tibial nerves were reduced significantly in patients of uncontrolled (HbA1c≥7%) DM (p<0.001). Sensory nerve conduction studies revealed significant reduction in SNAP amplitudes of median and ulnar sensory and sural nerves in the uncontrolled group (p<0.001). Electrophysiologically, 65.43% patients had mixed sensory-motor neuropathy (p<0.00001). Clinically severe DPN patients were higher (45.2%) within the uncontrolled (HbA1C ≥7%) group (p<0.00001). Similarly, severity in electrophysiological grading was more in patients with uncontrolled DM (48.8%) (p<0.00001). Conclusions: Neuropathic severity, either clinically or electrophysiologically, was associated with higher values of HbA1c. Journal of National Institute of Neurosciences Bangladesh, 2019;5(2): 177-184

scholarly journals Nerve Conduction Studies in Patients with Lumbosacral Radiculopathy Caused by Lumbar Intervertebral Disc Herniation

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Safa Yousif ◽  
Ammar Ahmed ◽  
Ahmed Abdelhai ◽  
Afraa Musa
Keyword(s):  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Tibial Nerve ◽  
Motor Nerve ◽  
H Reflex ◽  
Nerve Conduction Studies ◽  
Control Group ◽  
Motor Nerve Conduction ◽  
Lumbosacral Radiculopathy ◽  
F Wave

Background. Nerve conduction studies (NCS) are electrodiagnostic tests used to evaluate peripheral nerves functions and aid in the assessment of patients with neuromuscular complaints. There is contrasting evidence concerning the use of NCS in the assessment of patients with lumbosacral radiculopathy. Objectives. This study was conducted to evaluate nerve conduction studies abnormalities in patients with lumbosacral radiculopathy and to find out their relation to abnormal physical examination findings. Materials and Methods. Twenty-seven patients with lumbosacral radiculopathy caused by L4/5 or L5/S1 intervertebral disc prolapse confirmed by magnetic resonance imaging (MRI) were recruited in the study. Twenty-five healthy subjects matched in age and sex served as control. Motor nerve conduction study bilaterally for both common peroneal and tibial nerves, F-wave for both nerves, and H-reflex had been conducted. Results. No significant difference was found in the motor nerve conduction study parameters (latency, amplitude, and conduction velocity) between the patients group and the control group. There was significant prolongation in H-reflex latency of both symptomatic and asymptomatic side in the patients group compared to the control group ( P < 0.05 ). Also, F-wave latencies (F minimum, F maximum, and F mean) of the tibial nerve were significantly prolonged ( P < 0.05 ) compared to control. Conclusion. Prolonged H-reflex latency was the commonest encountered abnormality in our study followed by F-wave latencies of the tibial nerve.

Outcome of Carpal Tunnel Release in Diabetic Patients

1994 ◽  
Vol 19 (5) ◽  
pp. 626-629 ◽  
Author(s):  
M. M. AL-QATTAN ◽  
R. T. MANKTELOW ◽  
C. V. A. BOWEN
Keyword(s):  
Retrospective Study ◽  
Peripheral Neuropathy ◽  
Carpal Tunnel ◽  
Nerve Conduction ◽  
Complete Resolution ◽  
Carpal Tunnel Release ◽  
Nerve Conduction Studies ◽  
Diabetic Patients ◽  
Hand Symptoms

A retrospective study of 15 diabetic patients (20 hands), who underwent carpal tunnel release, was performed to determine the outcome. All patients had a minimum of 18 months of follow-up. Outcome was considered excellent if there was complete resolution of symptoms and this occurred in 35% of the treated hands. Eight hands (40%) had a good outcome with significant improvement of pre-operative symptoms. Outcome was considered poor when symptoms were minimally improved, unchanged, or worse after surgery and this occurred in 25% of treated hands. All hands with a poor final result had either no electrodiagnostic evidence of localized compression or only mild compression in pre-operative nerve conduction studies. It was postulated that the contribution of localized compression to pre-operative hand symptoms was less than the contribution of peripheral neuropathy in these hands.

The medial plantar and medial peroneal cutaneous nerve conduction studies for diabetic polyneuropathy

2011 ◽  
Vol 32 (5) ◽  
pp. 849-854 ◽  
Author(s):  
Yasar Altun ◽  
Ahmet Demirkol ◽  
Yener Tumay ◽  
Kazım Ekmekci ◽  
Ibrahim Unsal ◽  
...  
Keyword(s):  
Nerve Conduction ◽  
Diabetic Polyneuropathy ◽  
Nerve Conduction Studies ◽  
Cutaneous Nerve

Assessment of symptomatic diabetic patients with normal nerve conduction studies: Utility of cutaneous silent periods and autonomic tests

2011 ◽  
Vol 43 (3) ◽  
pp. 317-323 ◽  
Author(s):  
Pinar Kahraman Koytak ◽  
Baris Isak ◽  
Deniz Borucu ◽  
Kayihan Uluc ◽  
Tulin Tanridag ◽  
...  
Keyword(s):  
Nerve Conduction ◽  
Nerve Conduction Studies ◽  
Diabetic Patients ◽  
Autonomic Tests ◽  
Normal Nerve Conduction

scholarly journals Ranirestat Improved Nerve Conduction Velocities, Sensory Perception, and Intraepidermal Nerve Fiber Density in Rats with Overt Diabetic Polyneuropathy

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Saeko Asano ◽  
Tatsuhito Himeno ◽  
Tomohide Hayami ◽  
Mikio Motegi ◽  
Rieko Inoue ◽  
...  
Keyword(s):  
Placebo Group ◽  
Neurite Outgrowth ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Diabetic Polyneuropathy ◽  
Diabetic Rats ◽  
Diabetic Patients ◽  
Fiber Density ◽  
Conduction Velocities

Distal sensory-motor polyneuropathy is one of the most frequent diabetic complications. However, few therapies address the etiology of neurodegeneration in the peripheral nervous systems of diabetic patients. Several metabolic mechanisms have been proposed as etiologies of this polyneuropathy. In this study, we revisited one of those mechanisms, the polyol pathway, and investigated the curative effects of a novel strong aldose reductase inhibitor, ranirestat, in streptozotocin-induced diabetic rats with preexisting polyneuropathy. Twelve weeks after the onset of diabetes, rats which had an established polyneuropathy were treated once daily with a placebo, ranirestat, or epalrestat, over 6 weeks. Before and after the treatment, nerve conduction velocities and thermal perception threshold of hindlimbs were examined. After the treatment, intraepidermal fiber density was evaluated. As an ex vivo assay, murine dorsal root ganglion cells were dispersed and cultured with or without 1 μmol/l ranirestat for 48 hours. After the culture, neurite outgrowth was quantified using immunological staining. Sensory nerve conduction velocity increased in diabetic rats treated with ranirestat (43.3±3.6 m/s) compared with rats treated with placebo (39.8±2.3). Motor nerve conduction velocity also increased in the ranirestat group (45.6±3.9) compared with the placebo group (38.9±3.5). The foot withdrawal latency to noxious heating was improved in the ranirestat group (17.7±0.6 seconds) compared with the placebo group (20.6±0.6). The decrease in the intraepidermal fiber density was significant in the diabetic placebo group (21.6±1.7/mm) but not significant in the diabetic ranirestat group (26.2±1.2) compared with the nondiabetic placebo group (30.3±1.5). Neurite outgrowth was promoted in the neurons supplemented with ranirestat (control 1446±147 μm/neuron, ranirestat 2175±149). Ranirestat improved the peripheral nervous dysfunctions in rats with advanced diabetic polyneuropathy. Ranirestat could have potential for regeneration in the peripheral nervous system of diabetic rats.

Painful legs and moving toes

2021 ◽  
pp. practneurol-2021-002958
Author(s):  
Igor de Assis Franco ◽  
Thiago Cardoso Vale ◽  
Vitor Henrique Schulze ◽  
Marcus Vinicius Magno Goncalves
Keyword(s):  
Peripheral Nerve ◽  
Nerve Conduction ◽  
Peripheral Nerve Injury ◽  
Peroneal Nerve ◽  
Axonal Injury ◽  
Nerve Conduction Studies ◽  
The Other ◽  
Deep Peroneal Nerve ◽  
Flexion Extension ◽  
Second Toe

A 40-year-old woman reported involuntary and irregular movements of her left toes accompanied by pain. This arose following arthroscopy after a sprained left ankle. She had involuntary flexion–extension and abduction and adduction movements of the hallux and the other toes, with reduced pinprick sensation on the skin web between the left hallux and the second toe. Nerve conduction studies confirmed a deep peroneal nerve axonal injury. We diagnosed the syndrome of painful legs and moving toes, provoked by a peripheral nerve injury. Her symptoms have persisted despite pregabalin, gabapentin and amitriptyline.

scholarly journals Abnormal Nerve Conduction Study Findings Indicating the Existence of Peripheral Neuropathy in Multiple Sclerosis and Neuromyelitis Optica

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Yoko Warabi ◽  
Mikihiro Yamazaki ◽  
Toshio Shimizu ◽  
Masahiro Nagao
Keyword(s):  
Diabetes Mellitus ◽  
Multiple Sclerosis ◽  
Peripheral Neuropathy ◽  
Neuromyelitis Optica ◽  
Nerve Conduction ◽  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Nerve Conduction Studies ◽  
The Other ◽  
Significant Difference ◽  
Inflammatory Demyelinating Polyneuropathy

Objective. Chronic inflammatory demyelinating polyneuropathy (CIDP) has been reported in patients with multiple sclerosis (MS). However, there have been limited reports of peripheral neuropathy as a complication of neuromyelitis optica (NMO). In this paper, we showed the characteristics and differences between peripheral neuropathy as a complication of MS and NMO.Method. We analyzed a series of 58 MS and 28 NMO patients and evaluated nerve conduction studies (NCS) in 21 MS and 5 NMO patients.Results. Six of the 58 MS and 3 of the 28 NMO patients revealed abnormal NCS findings. Three (5.2%) of the 58 MS patients fulfilled the criteria for CIDP. One (3.6%) of the 28 NMO patients showed peripheral neuropathy at the same time of NMO relapse, although CIDP was not seen in NMO. The other 5 (3 MS and 2 NMO) patients were complicated with neuropathy caused by concomitant diabetes mellitus and Sjögren’s syndrome.Conclusion. Frequency of abnormal NCS findings might exhibit no significant difference between MS and NMO, although the cause and pathophysiology of peripheral neuropathy were different in MS and in NMO. There might be a group of NMO who were affected simultaneously in the central and peripheral nervous tissues.

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