scholarly journals Blue rubber bleb nevus syndrome: case report

2003 ◽  
Vol 58 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Magaly Gemio Teixeira ◽  
Marcos Vinicius Perini ◽  
Carlos Frederico S. Marques ◽  
Angelita Habr-Gama ◽  
Desidério Kiss ◽  
...  
Keyword(s):  
Reliable Method ◽  
Intestinal Resection ◽  
Blood Transfusions ◽  
Effective Management ◽  
Effective Technique ◽  
Chronic Anemia ◽  
Systemic Disorder ◽  
Multiple Blood ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

The case of a patient with blue rubber bleb nevus syndrome who is infected by acquired immunodeficiency syndrome virus due to multiple blood transfusions is presented. This case shows that although it is a rare systemic disorder, blue rubber bleb nevus syndrome has to be considered in the differential diagnosis of chronic anemia or gastrointestinal bleeding. Patients should be investigated by endoscopy, which is the most reliable method for detecting these lesions. The patient underwent gastroscopy and enteroscopy via enterotomy with identification of all lesions. Minimal resection of the larger lesions and string-purse suture of the smaller ones involving all the layers of the intestine were performed. The string-purse suture of the lesions detected by enteroscopy proved to be an effective technique for handling these lesions, avoiding extensive intestinal resection and stopping the bleeding. Effective management of these patients demands aggressive treatment and should be initiated as soon as possible to avoid risks involved in blood transfusions, as occurred in this case.

Perioperative blood transfusions and cancer recurrence.

1988 ◽  
Vol 6 (8) ◽  
pp. 1348-1354 ◽  
Author(s):  
H S Wu ◽  
A G Little
Keyword(s):  
Natural Killer Cells ◽  
Acquired Immunodeficiency Syndrome ◽  
Cancer Recurrence ◽  
Cancer Surgery ◽  
The Other ◽  
Blood Transfusions ◽  
Suppressor T Lymphocytes ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Worse Prognosis

This collective review addresses the issue of transfusion-induced immunosuppression as it relates to patients undergoing cancer surgery. Patients receiving perioperative blood transfusions have a significantly worse prognosis than patients undergoing cancer surgery without a perioperative transfusion. It is thought that this is because transfusions produce a nonspecific immunosuppression by increasing the number and/or activity of suppressor T lymphocytes, decreasing the number of natural killer cells, and inducing anti-idiotypic antibodies. This risk, particularly when considered with the other risks of transfusion such as hepatitis or the acquired immunodeficiency syndrome (AIDS), suggests that criteria for transfusion of these patients should be stringent and related to an unequivocal need for replenishment of RBCs.

Fulminant Parvovirus Infection Following Erythropoietin Treatment in a Patient With Acquired Immunodeficiency Syndrome

2000 ◽  
Vol 124 (3) ◽  
pp. 441-445
Author(s):  
Joanna Borkowski ◽  
Mojghan Amrikachi ◽  
S. David Hudnall
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Acquired Immunodeficiency Syndrome ◽  
Erythroid Progenitors ◽  
Chronic Anemia ◽  
Erythroid Hyperplasia ◽  
Erythropoietin Treatment ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Rapid Correction

Abstract We report the case of a 41-year-old black man with acquired immunodeficiency syndrome who developed a severe chronic anemia due to parvovirus infection. Bone marrow biopsy revealed erythroid aplasia. The infectious nature of the anemia was not recognized, and the patient was treated with erythropoietin. The patient's reticulocyte response was inadequate, however, and he remained anemic. A second bone marrow biopsy showed erythroid hyperplasia and prominent intranuclear parvovirus inclusions within erythroid progenitors. Erythropoietin was discontinued and was followed by a course of intravenous immunoglobulin, which resulted in rapid correction of anemia. To our knowledge, this is the first reported case of fulminant human parvovirus infection exacerbated by erythropoietin administration and documented by sequential bone marrow histologic examination. This case illustrates the critical importance of considering parvovirus in the etiology of chronic anemia with erythroid aplasia in immunocompromised patients.

Blood-borne Infections Associated with Transfusion

1992 ◽  
Vol 7 (2) ◽  
pp. 67-83 ◽  
Author(s):  
Paul P. Ulrich ◽  
Girish N. Vyas
Keyword(s):  
Blood Supply ◽  
The United States ◽  
Infectious Complications ◽  
Blood Transfusions ◽  
Infectious Agents ◽  
Homologous Blood Transfusion ◽  
Recent Developments ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Attending Physicians

The epidemic of acquired immunodeficiency syndrome (AIDS) and the realization that transmission of human immunodeficiency virus is caused by homologous blood transfusion have changed the way physicians and their patients view the safety of hemotherapy. Considering that nearly four million patients receive the lifesaving benefits of blood transfusions every year in the United States, we need to recognize and reduce the inherent biological complications of this therapy. Currently, a major concern is the transmission of blood-borne infectious agents and the establishment of persistent infection in transfusion recipients, which is apparently facilitated by suppression of the recipient's hematopoietic and immune systems. Education of blood donors, patients, and attending physicians regarding infectious complications of transfusion is essential and remains the most effective procedure for making rational decisions. Before giving blood transfusions, astute physicians should calculate a risk/benefit ratio and communicate it to the patient or family. Potential recipients of transfusions can be assured that the blood supply is safer now than at any time in the past, although there is still a very small risk for the transmission of infectious agents that cause chronic diseases, such as hepatitis, AIDS, neuropathies, and leukemias. It is essential that everyone understands that the goal of a zero-risk blood supply is not attainable. Recent developments in molecular biology and biotechnology, however, provide opportunities for further reduction of infectious complications of blood transfusions.

Immunogold labeling of Pneumocystis carinii for Electron microscopy

1991 ◽  
Vol 49 ◽  
pp. 270-271
Author(s):  
Michael P. Goheen ◽  
Marilyn S. Bartlett ◽  
James W. Smith
Keyword(s):  
Electron Microscopy ◽  
Pneumocystis Carinii ◽  
Severe Pneumonia ◽  
Culture Fluid ◽  
Immunogold Labeling ◽  
Antigenic Sites ◽  
Transmission Electron ◽  
Response To Chemotherapy ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Studies of the biology of Pneumocystis carinii (PC) are of increasing importance because this extracellular pathogen is a frequent source of severe pneumonia in patients with acquired immunodeficiency syndrome (AIDS) and is a leading cause of mortality in these patients. Immunoelectron microscopic localization of antigenic sites on the surface of PC would improve the understanding of these sites and their role in pathenogenisis of the disease and response to chemotherapy. The purpose of this study was to develop a methodology for visualizing immunoreactive sites on PC with transmission electron microscopy (TEM) using immunogold labeled probes.Trophozoites of PC were added to spinner flask cultures and allowed to grow for 7 days, then aliquots of tissue culture fluid were centrifuged at 12,000 RPM for 30 sec. Pellets of organisims were fixed in either 1% glutaraldehyde, 0.1% glutaraldehyde-4% paraformaldehyde, or 4% paraformaldehyde for 4h. All fixatives were buffered with 0.1M Na cacodylate and the pH adjusted to 7.1. After fixation the pellets were rinsed in 0.1M Na cacodylate (3X), dehydrated with ethanol, and immersed in a 1:1 mixture of 95% ethanol and LR White resin.

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