scholarly journals Citotoxic activity evaluation of essential oils and nanoemulsions of Drimys angustifolia and D. brasiliensis on human glioblastoma (U-138 MG) and human bladder carcinoma (T24) cell lines in vitro

2013 ◽  
Vol 23 (2) ◽  
pp. 259-267 ◽  
Author(s):  
Madson R.F. Gomes ◽  
Roselena S. Schuh ◽  
Ana L.B. Jacques ◽  
Otávio A. Augustin ◽  
Sérgio A.L. Bordignon ◽  
...  
Keyword(s):  
Essential Oils ◽  
Cell Lines ◽  
Bladder Carcinoma ◽  
Human Bladder ◽  
Human Glioblastoma ◽  
Activity Evaluation

Stability of lectin binding properties expressed by human bladder carcinoma cell lines passaged in vitro or in nude mice

1988 ◽  
Vol 16 (6) ◽  
pp. 407-414 ◽  
Author(s):  
P. J. Russell ◽  
J. Wotherspoon ◽  
M. Jelbart ◽  
J. Philips ◽  
D. Raghavan
Keyword(s):  
Cell Lines ◽  
Nude Mice ◽  
Bladder Carcinoma ◽  
Carcinoma Cell ◽  
Lectin Binding ◽  
Human Bladder ◽  
Binding Properties ◽  
Carcinoma Cell Lines

Antiproliferative Activities of Interferons Against Human Bladder Carcinoma Cell Lines in Vitro

1984 ◽  
Vol 132 (4) ◽  
pp. 800-803 ◽  
Author(s):  
E.C. Borden ◽  
D.S. Groveman ◽  
T. Nasu ◽  
C. Reznikoff ◽  
G.T. Bryan
Keyword(s):  
Cell Lines ◽  
Bladder Carcinoma ◽  
Carcinoma Cell ◽  
Human Bladder ◽  
Carcinoma Cell Lines ◽  
Antiproliferative Activities

scholarly journals Lomeguatrib Increases the Radiosensitivity of MGMT Unmethylated Human Glioblastoma Multiforme Cell Lines

2021 ◽  
Vol 22 (13) ◽  
pp. 6781
Author(s):  
Anna Kirstein ◽  
Daniela Schilling ◽  
Stephanie E. Combs ◽  
Thomas E. Schmid
Keyword(s):  
Glioblastoma Multiforme ◽  
Cell Lines ◽  
Dna Methyltransferase ◽  
Treatment Options ◽  
Treatment Resistance ◽  
Cell Cycle Distribution ◽  
Human Glioblastoma ◽  
Human Glioblastoma Multiforme ◽  
Mgmt Protein

Background: Treatment resistance of glioblastoma multiforme to chemo- and radiotherapy remains a challenge yet to overcome. In particular, the O6-methylguanine-DNA-methyltransferase (MGMT) promoter unmethylated patients have only little benefit from chemotherapy treatment using temozolomide since MGMT counteracts its therapeutic efficacy. Therefore, new treatment options in radiotherapy need to be developed to inhibit MGMT and increase radiotherapy response. Methods: Lomeguatrib, a highly specific MGMT inhibitor, was used to inactivate MGMT protein in vitro. Radiosensitivity of established human glioblastoma multiforme cell lines in combination with lomeguatrib was investigated using the clonogenic survival assay. Inhibition of MGMT was analyzed using Western Blot. Cell cycle distribution and apoptosis were investigated to determine the effects of lomeguatrib alone as well as in combination with ionizing radiation. Results: Lomeguatrib significantly decreased MGMT protein and reduced radiation-induced G2/M arrest. A radiosensitizing effect of lomeguatrib was observed when administered at 1 µM and increased radioresistance at 20 µM. Conclusion: Low concentrations of lomeguatrib elicit radiosensitization, while high concentrations mediate a radioprotective effect.

Factors influencing the sensitivity of two human bladder carcinoma cell lines to cis-diamminedichloro-platinum(II)

1987 ◽  
Vol 61 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Philip Bedford ◽  
M.Claire Walker ◽  
Harbans L. Sharma ◽  
Anusha Perera ◽  
Charles A. McAuliffe ◽  
...  
Keyword(s):  
Cell Lines ◽  
Bladder Carcinoma ◽  
Carcinoma Cell ◽  
Human Bladder ◽  
Carcinoma Cell Lines ◽  
Factors Influencing

scholarly journals THROMBOPLASTIC AND FIBRINOLYTIC ACTIVITIES OF IN VITRO CULTIVATED KK-47 CELLS ESTABLISHED FROM A HUMAN BLADDER CARCINOMA

1978 ◽  
Vol 69 (10) ◽  
pp. 1328-1333
Author(s):  
Haruo Hisazumi ◽  
Yasuo Saitoh ◽  
Masahiro Katoh ◽  
Kazuyoshi Nakajima ◽  
Tetsuji Kobayashi ◽  
...  
Keyword(s):  
Bladder Carcinoma ◽  
Human Bladder
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