in vitro invasiveness
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2021 ◽  
Author(s):  
Andrea McWhorter ◽  
Jane Owens ◽  
Mary Valcanis ◽  
Liberty Olds ◽  
Cecilia Myers ◽  
...  

Neuroreport ◽  
2019 ◽  
Vol 30 (17) ◽  
pp. 1135-1142
Author(s):  
Zhigang Pan ◽  
Qiangbin Zhu ◽  
Wei You ◽  
Canfang Shen ◽  
Weipeng Hu ◽  
...  

2018 ◽  
Vol 33 (4) ◽  
pp. 633-640 ◽  
Author(s):  
Karina Ramírez ◽  
Areli Burgueño‐Roman ◽  
Nohelia Castro‐del Campo ◽  
Héctor S. López‐Moreno ◽  
Cristobal Chaidez

2018 ◽  
Vol 29 (14) ◽  
pp. 1704-1717 ◽  
Author(s):  
Anushree C. Gulvady ◽  
Fatemeh Dubois ◽  
Nicholas O. Deakin ◽  
Gregory J. Goreczny ◽  
Christopher E. Turner

The focal adhesion proteins Hic-5 and paxillin have been previously identified as key regulators of MDA-MB-231 breast cancer cell migration and morphologic mesenchymal-amoeboid plasticity in three-dimensional (3D) extracellular matrices (ECMs). However, their respective roles in other cancer cell types have not been evaluated. Herein, utilizing 3D cell–derived matrices and fibronectin-coated one-dimensional substrates, we show that across a variety of cancer cell lines, the level of Hic-5 expression serves as the major indicator of the cells primary morphology, plasticity, and in vitro invasiveness. Domain mapping studies reveal sites critical to the functions of both Hic-5 and paxillin in regulating phenotype, while ectopic expression of Hic-5 in cell lines with low endogenous levels of the protein is sufficient to induce a Rac1-dependent mesenchymal phenotype and, in turn, increase amoeboid-mesenchymal plasticity and invasion. We show that the activity of vinculin, when coupled to the expression of Hic-5 is required for the mesenchymal morphology in the 3D ECM. Taken together, our results identify Hic-5 as a critical modulator of tumor cell phenotype that could be utilized in predicting tumor cell migratory and invasive behavior in vivo.


2018 ◽  
Vol 149 (5) ◽  
pp. 503-516 ◽  
Author(s):  
Njainday Pulo Jobe ◽  
Veronika Živicová ◽  
Alžběta Mifková ◽  
Daniel Rösel ◽  
Barbora Dvořánková ◽  
...  

2016 ◽  
Vol 53 (2) ◽  
pp. 96-98 ◽  
Author(s):  
Shuya Yano ◽  
Kiyoto Takehara ◽  
Hiroshi Tazawa ◽  
Hiroyuki Kishimoto ◽  
Shunsuke Kagawa ◽  
...  

2011 ◽  
Vol 9 (6) ◽  
pp. 673-687 ◽  
Author(s):  
Joanna Bialek ◽  
Usakorn Kunanuvat ◽  
Sabine Hombach-Klonisch ◽  
Antje Spens ◽  
Joerg Stetefeld ◽  
...  

2010 ◽  
Vol 20 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Fabien Rondepierre ◽  
Bernadette Bouchon ◽  
Mathilde Bonnet ◽  
Nicole Moins ◽  
Jean M. Chezal ◽  
...  

2010 ◽  
Vol 31 (6) ◽  
pp. 401-411 ◽  
Author(s):  
Kazuhito Yoshikawa ◽  
Jun-ichi Hamada ◽  
Mitsuhiro Tada ◽  
Takeshi Kameyama ◽  
Koji Nakagawa ◽  
...  

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