Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy

Jafar Mohseni; Z.A.M.H. Zabidi-Hussin; Teguh Haryo Sasongko

doi:10.1590/s1415-47572013000300001

Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy

Genetics and Molecular Biology ◽

10.1590/s1415-47572013000300001 ◽

2013 ◽

Vol 36 (3) ◽

pp. 299-307 ◽

Cited By ~ 30

Author(s):

Jafar Mohseni ◽

Z.A.M.H. Zabidi-Hussin ◽

Teguh Haryo Sasongko

Keyword(s):

Spinal Muscular Atrophy ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitors ◽

Muscular Atrophy ◽

Potential Treatment

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Carboxylic acid derivatives of histone deacetylase inhibitors induce full length SMN2 transcripts: a promising target for spinal muscular atrophy therapeutics

Archives of Medical Science ◽

10.5114/aoms.2011.22072 ◽

2011 ◽

Vol 2 ◽

pp. 230-234 ◽

Cited By ~ 11

Author(s):

Didem Dayangac-Erden ◽

Gamze Bora-Tatar ◽

Sevim Dalkara ◽

Ayhan S. Demir ◽

Hayat Erdem-Yurter

Keyword(s):

Carboxylic Acid ◽

Spinal Muscular Atrophy ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitors ◽

Muscular Atrophy ◽

Full Length ◽

Promising Target ◽

Derivatives Of

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In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2006.03868.x ◽

2006 ◽

Vol 98 (1) ◽

pp. 193-202 ◽

Cited By ~ 105

Author(s):

Eric Hahnen ◽

Ilker Y. Eyupoglu ◽

Lars Brichta ◽

Kirsten Haastert ◽

Christian Trankle ◽

...

Keyword(s):

Spinal Muscular Atrophy ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitors ◽

Second Generation ◽

Muscular Atrophy ◽

Ex Vivo

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Applicability of Histone Deacetylase Inhibition for the Treatment of Spinal Muscular Atrophy

Neurotherapeutics ◽

10.1007/s13311-013-0209-2 ◽

2013 ◽

Vol 10 (4) ◽

pp. 677-687 ◽

Cited By ~ 8

Author(s):

Sebastian Lunke ◽

Assam El-Osta

Keyword(s):

Spinal Muscular Atrophy ◽

Histone Deacetylase ◽

Muscular Atrophy ◽

Histone Deacetylase Inhibition

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The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells

Human Genetics ◽

10.1007/s00439-006-0186-1 ◽

2006 ◽

Vol 120 (1) ◽

pp. 101-110 ◽

Cited By ~ 91

Author(s):

Markus Riessland ◽

Lars Brichta ◽

Eric Hahnen ◽

Brunhilde Wirth

Keyword(s):

Spinal Muscular Atrophy ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Muscular Atrophy ◽

Protein Levels ◽

Deacetylase Inhibitor

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Combined treatment with the histone deacetylase inhibitor LBH589 and a splice‐switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells

Journal of Neurochemistry ◽

10.1111/jnc.14935 ◽

2020 ◽

Vol 153 (2) ◽

pp. 264-275 ◽

Cited By ~ 7

Author(s):

Vittoria Pagliarini ◽

Marika Guerra ◽

Valentina Di Rosa ◽

Claudia Compagnucci ◽

Claudio Sette

Keyword(s):

Spinal Muscular Atrophy ◽

Histone Deacetylase ◽

Antisense Oligonucleotide ◽

Histone Deacetylase Inhibitor ◽

Muscular Atrophy ◽

Combined Treatment ◽

Deacetylase Inhibitor

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Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition

Human Molecular Genetics ◽

10.1093/hmg/ddn357 ◽

2008 ◽

Vol 18 (2) ◽

pp. 304-317 ◽

Cited By ~ 74

Author(s):

Jan Hauke ◽

Markus Riessland ◽

Sebastian Lunke ◽

Ilker Y. Eyüpoglu ◽

Ingmar Blümcke ◽

...

Keyword(s):

Dna Methylation ◽

Spinal Muscular Atrophy ◽

Motor Neuron ◽

Histone Deacetylase ◽

Disease Severity ◽

Muscular Atrophy ◽

Survival Motor Neuron ◽

Survival Motor Neuron Gene ◽

Histone Deacetylase Inhibition

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Histone Deacetylase Inhibition Activity and Molecular Docking of (E )-Resveratrol: Its Therapeutic Potential in Spinal Muscular Atrophy

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2009.00781.x ◽

2009 ◽

Vol 73 (3) ◽

pp. 355-364 ◽

Cited By ~ 32

Author(s):

Didem Dayangaç-Erden ◽

Gamze Bora ◽

Peruze Ayhan ◽

Çetin Kocaefe ◽

Sevim Dalkara ◽

...

Keyword(s):

Molecular Docking ◽

Spinal Muscular Atrophy ◽

Histone Deacetylase ◽

Therapeutic Potential ◽

Muscular Atrophy ◽

Inhibition Activity ◽

Histone Deacetylase Inhibition

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A Randomized Phase 1 Safety, Pharmacokinetic and Pharmacodynamic Study of the Novel Myostatin Inhibitor Apitegromab (SRK-015): A Potential Treatment for Spinal Muscular Atrophy

Advances in Therapy ◽

10.1007/s12325-021-01757-z ◽

2021 ◽

Author(s):

Doreen Barrett ◽

Sanela Bilic ◽

Yung Chyung ◽

Shaun M. Cote ◽

Ryan Iarrobino ◽

...

Keyword(s):

Spinal Muscular Atrophy ◽

Muscular Atrophy ◽

Phase 1 ◽

The Novel ◽

Potential Treatment ◽

Pharmacodynamic Study

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Increasing SMN levels using the histone deacetylase inhibitor SAHA ameliorates defects in skeletal muscle microvasculature in a mouse model of severe spinal muscular atrophy

Neuroscience Letters ◽

10.1016/j.neulet.2013.03.052 ◽

2013 ◽

Vol 544 ◽

pp. 100-104 ◽

Cited By ~ 11

Author(s):

Eilidh Somers ◽

Markus Riessland ◽

Julia Schreml ◽

Brunhilde Wirth ◽

Thomas H. Gillingwater ◽

...

Keyword(s):

Skeletal Muscle ◽

Mouse Model ◽

Spinal Muscular Atrophy ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Muscular Atrophy ◽

Deacetylase Inhibitor

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Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice

Human Molecular Genetics ◽

10.1093/hmg/dds286 ◽

2012 ◽

Vol 21 (20) ◽

pp. 4448-4459 ◽

Cited By ~ 40

Author(s):

Katherine V. Bricceno ◽

Paul J. Sampognaro ◽

James P. Van Meerbeke ◽

Charlotte J. Sumner ◽

Kenneth H. Fischbeck ◽

...

Keyword(s):

Spinal Muscular Atrophy ◽

Histone Deacetylase ◽

Muscular Atrophy ◽

Histone Deacetylase Inhibition

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