scholarly journals Accuracy of the 14C-urea breath test for the diagnosis of Helicobacter pylori

2002 ◽  
Vol 120 (3) ◽  
pp. 68-70 ◽  
Author(s):  
Ana Thereza Britto Gomes ◽  
Luciano Kowalsky Coelho ◽  
Marie Secaf ◽  
José Luiz Pimenta Módena ◽  
Luiz Ernesto de Almeida Troncon ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Gastrointestinal Endoscopy ◽  
Urea Breath Test ◽  
Simple Device ◽  
Upper Gastrointestinal Endoscopy ◽  
Urease Test ◽  
Great Relevance ◽  
Study Setting ◽  
Upper Gastrointestinal

CONTEXT: The development of simple, accurate and low-expense techniques for detection of Helicobacter pylori infection has great relevance. OBJECTIVE: To determine the accuracy of a rapid 14C-urea breath test (UBT) employing a very simple device for breathed air collection. DESIGN: Prospective study. SETTING: Hospital das Clinicas of the Faculty of Medicine of Ribeirão Preto. PARTICIPANTS: One hundred and thirty-seven adult patients who underwent upper gastrointestinal endoscopy in the Clinical Hospital. MAIN MEASUREMENTS: Histology for Helicobacter pylori (HP); urease test; urea breath test (UBT). RESULTS: One hundred and fifteen patients were infected by HP (HP+) according to both histology and the urease test, and 22 patients were HP-negative (HP-), according to the same two tests. UBT was capable of discriminating between HP+ and HP- in a way that was similar to the combination of urease test and histology. When this combination of results is taken as the "gold standard" for HP infection, the sensitivity and specificity of UBT are both greater than 90% for a range of cut-off points and breathed air collection times. CONCLUSION: The rapid UBT employing a simple device for air collection has a high accuracy in determining HP infection.

scholarly journals Helicobacter pylori eradication in renal transplant candidates

2022 ◽  
Author(s):  
Mariana E. Maioli ◽  
Raquel F. N. Frange ◽  
Cintia M. C. Grion ◽  
Vinicius D. A. Delfino
Keyword(s):  
Chronic Kidney Disease ◽  
Helicobacter Pylori ◽  
Gastrointestinal Endoscopy ◽  
Eradication Rate ◽  
Upper Gastrointestinal Endoscopy ◽  
Rapid Urease Test ◽  
Urease Test ◽  
Transplant Candidates ◽  
H Pylori ◽  
Upper Gastrointestinal

Abstract Introduction: Treatment for Helicobacter pylori (H. pylori) infection is recommended in transplant candidates due to the association between this infection and gastrointestinal disorders, which could significantly increase morbidity after renal transplantation with the use of immunosuppression. The objective of this study was to analyze the rate of eradication of H. pylori after antimicrobial treatment in chronic kidney disease patients who are candidates for kidney transplantation. Methods: A multicenter prospective cohort study was conducted. All adult chronic kidney disease patients seen at our institution were included. In the pre-transplantation evaluation, 83 patients underwent an upper gastrointestinal endoscopy with 2 diagnostic methods to detect H. pylori: histology and the rapid urease test. In total, 33 patients with H. pylori infection received treatment with 20 mg omeprazole, 500 mg amoxicillin, and 500 mg clarithromycin once daily for 14 days. Another upper gastrointestinal endoscopy was performed 8 to 12 weeks after the end of treatment to check for healing. Results: The study showed a prevalence of H. pylori in 51 (61.4%) patients. Histology was positive in 50 (98%) patients and the rapid urease test was positive in 31 (60.8%). The infection eradication rate was 48.5% (16 patients). Conclusions: There was a high prevalence rate of H. pylori and a low eradication rate after the long-term antimicrobial triple scheme used. The association of the rapid urease test with gastric mucosa histology did not increase the detection rate of H. pylori.

Can urea breath test (UBT) replace rapid urea test (RUT)?

2018 ◽  
Vol 90 (4) ◽  
pp. 6-10 ◽  
Author(s):  
Łukasz Nawacki ◽  
Agata Czyż ◽  
Piotr Bryk ◽  
Dorota Kozieł ◽  
Renata Stępień ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Tract ◽  
Positive Result ◽  
Breath Test ◽  
Urease Activity ◽  
Urea Breath Test ◽  
Upper Gastrointestinal Tract ◽  
Study Group ◽  
Urease Test ◽  
Upper Gastrointestinal

Background: Helicobacter pylori (Hp) is classified by the International Agency for Research on Cancer (IARC) as a Group 1 carcinogen. Its influence on the carcinogenesis of gastric cancer has been confirmed in many researches. The conclusion is obvious- early detection and eradication of Hp can prevent the development of the disease. Methods: The objective of the study was to analyse the clinical and practical value of Carbon-13 urea breath test (UBT) in patients hospitalized due to pain complaints in the upper abdomen and dyspeptic symptoms. Fifty patients were enrolled in the study. Each patient underwent urea breath test according to the instruction included by the producer. Thereafter, each patient included in the study group was performed endoscopy of the upper gastrointestinal tract with the biopsy of the mucosa to determine the urease activity with rapid urease test (RUT). Results: In the study group, 14 patients (28%) achieved a positive urease test result which was confirmed in RUT. Four (8%) patients, despite a positive breath test, did not have a positive result in urease activity from gastric mucosa. In 2 cases (4%) despite negative result of UBT there was urease actitvity confirmed in gastroscopic sections. The remaining 30 patients (60%) had a negative result in both studies. Conclusions: The limited availability of the gold standard for diagnostics of upper gastrointestinal tract diseases (gastroscopy) is the basis for the search for new methods for the detection of Helicobacter pylori infection. The urea breath test is a method of high sensitivity and specificity. The positive result of urea breath test may be the basis for the inclusion of eradication therapy.

Assessment of Degree of Health of the Stomach by Concomitant Measurement of Serum Pepsinogen and Serum Helicobacter Pylori Antibodies

2010 ◽  
Vol 25 (4) ◽  
pp. 207-212 ◽  
Author(s):  
Kazuhiko Inoue ◽  
Tomoo Fujisawa ◽  
Ken Haruma
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Endoscopy ◽  
Upper Gastrointestinal Endoscopy ◽  
Gastric Adenoma ◽  
Fundic Gland ◽  
Peptic Ulcers ◽  
Serum Pepsinogen ◽  
Group A ◽  
Group B ◽  
Upper Gastrointestinal

The stomach was assessed by measuring serum pepsinogen (PG) and Helicobacter pylori (Hp) antibodies by immunoassay, based on the findings of upper gastrointestinal endoscopy performed on the same day. The assessment involved 1,636 individuals who visited the hospital for general medical checkups. Those negative for Hp antibodies and PG were grouped in group A, Hp-positive/PG-negative subjects were included in group B, and PG-positive subjects in group C. Group A comprised 660 subjects (40.3%), group B 514 (31.4%), and group C 462 (28.2%). Gastric cancer was detected in 0.87% (4/462) in group C, 0.19% (1/514) in group B, and 0% (0/660) in group A. All four patients with gastric adenoma were in group C. Hyperplastic polyps were detected most frequently in group C followed by group B, while there were no cases in group A. By contrast, most fundic gland polyps were found in group A. The detection rate of peptic ulcers was highest in group B, while that of reflux esophagitis was highest in group A. These findings suggest that the “degree of health” of the stomach can be assessed by measuring serum PG and Hp antibodies.

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