Prevalence of Helicobacter pylori prevalence and upper gastrointestinal endoscopy in HIV/AIDS patients with gastrointestinal symptoms in the University Teaching Hospitals in Cameroon

The stomach was assessed by measuring serum pepsinogen (PG) and Helicobacter pylori (Hp) antibodies by immunoassay, based on the findings of upper gastrointestinal endoscopy performed on the same day. The assessment involved 1,636 individuals who visited the hospital for general medical checkups. Those negative for Hp antibodies and PG were grouped in group A, Hp-positive/PG-negative subjects were included in group B, and PG-positive subjects in group C. Group A comprised 660 subjects (40.3%), group B 514 (31.4%), and group C 462 (28.2%). Gastric cancer was detected in 0.87% (4/462) in group C, 0.19% (1/514) in group B, and 0% (0/660) in group A. All four patients with gastric adenoma were in group C. Hyperplastic polyps were detected most frequently in group C followed by group B, while there were no cases in group A. By contrast, most fundic gland polyps were found in group A. The detection rate of peptic ulcers was highest in group B, while that of reflux esophagitis was highest in group A. These findings suggest that the “degree of health” of the stomach can be assessed by measuring serum PG and Hp antibodies.

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Gastroduodenal Morphology and Related Symptoms in Chronic Alcoholics

Diagnostic and Therapeutic Endoscopy ◽

10.1155/dte.4.29 ◽

1997 ◽

Vol 4 (1) ◽

pp. 29-33 ◽

Cited By ~ 1

Author(s):

T. Hauge ◽

J. Persson ◽

Å. Nilsson

Keyword(s):

Electron Microscopy ◽

Scanning Electron Microscopy ◽

Gastrointestinal Endoscopy ◽

Gastrointestinal Symptoms ◽

Control Group ◽

Upper Gastrointestinal Endoscopy ◽

Alcohol Group ◽

Group 12 ◽

Upper Gastrointestinal ◽

Scanning Electron

Twenty-four chronic alcoholics admitted to hospital for detoxification after a drinking spree were examined by upper gastrointestinal endoscopy. Biopsy specimens were taken from corpus/fundus, antrum and duodenum for tissue histology (eosin stain). From the duodenum villus index and ultrastructure (scanning electron microscopy, SEM) were also performed. As a control group 12 subjectively healthy non-alcoholics referred to upper gastrointestinal endoscopy mainly for dyspepsia were chosen.Gastrointestinal symptoms were common in alcoholics (88%). Endoscopic and histological gastroduodenitis were not more common in the alcohol group. There was no correlation between gastrointestinal symptoms and endoscopic or histological gastroduodenitis in both groups. In the duodenum, 50% of the alcoholics and 82% in the control group had alterations by scanning electron microscopy. Ten of the 11 alcoholics with an abnormal ultrastructure had diarrhoea. In the control group dyspepsia (ulcus suspect) was correlated to a pathological SEM.

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Accuracy of the 14C-urea breath test for the diagnosis of Helicobacter pylori

Sao Paulo Medical Journal ◽

10.1590/s1516-31802002000300002 ◽

2002 ◽

Vol 120 (3) ◽

pp. 68-70 ◽

Cited By ~ 6

Author(s):

Ana Thereza Britto Gomes ◽

Luciano Kowalsky Coelho ◽

Marie Secaf ◽

José Luiz Pimenta Módena ◽

Luiz Ernesto de Almeida Troncon ◽

...

Keyword(s):

Helicobacter Pylori ◽

Breath Test ◽

Gastrointestinal Endoscopy ◽

Urea Breath Test ◽

Simple Device ◽

Upper Gastrointestinal Endoscopy ◽

Urease Test ◽

Great Relevance ◽

Study Setting ◽

Upper Gastrointestinal

CONTEXT: The development of simple, accurate and low-expense techniques for detection of Helicobacter pylori infection has great relevance. OBJECTIVE: To determine the accuracy of a rapid 14C-urea breath test (UBT) employing a very simple device for breathed air collection. DESIGN: Prospective study. SETTING: Hospital das Clinicas of the Faculty of Medicine of Ribeirão Preto. PARTICIPANTS: One hundred and thirty-seven adult patients who underwent upper gastrointestinal endoscopy in the Clinical Hospital. MAIN MEASUREMENTS: Histology for Helicobacter pylori (HP); urease test; urea breath test (UBT). RESULTS: One hundred and fifteen patients were infected by HP (HP+) according to both histology and the urease test, and 22 patients were HP-negative (HP-), according to the same two tests. UBT was capable of discriminating between HP+ and HP- in a way that was similar to the combination of urease test and histology. When this combination of results is taken as the "gold standard" for HP infection, the sensitivity and specificity of UBT are both greater than 90% for a range of cut-off points and breathed air collection times. CONCLUSION: The rapid UBT employing a simple device for air collection has a high accuracy in determining HP infection.

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Association Between Vitamin D Receptor Gene Polymorphisms and Helicobacter Pylori Infection

The Open Biomarkers Journal ◽

10.2174/1875318302010010008 ◽

2020 ◽

Vol 10 (1) ◽

pp. 8-14

Author(s):

Amal A. Mohamed ◽

Shorouk Moussa ◽

Mahmoud M. Shaheen ◽

Sherief Abd-Elsalam ◽

Rehab Ahmed ◽

...

Keyword(s):

Vitamin D ◽

Helicobacter Pylori ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Gastrointestinal Symptoms ◽

Upper Gastrointestinal Endoscopy ◽

Positive Group ◽

Biopsy Specimens ◽

H Pylori ◽

Upper Gastrointestinal

Background & Aims: Human genetic polymorphism has been reported in the susceptibility and clinical development of infection. In this regard, this study aimed to investigate the link between Vitamin D Receptor (VDR) gene polymorphism and H. pylori infection. Materials and Methods: This cross-sectional study was conducted on 224 adult patients with upper gastrointestinal symptoms who underwent an upper gastrointestinal endoscopy between July 2017 and May 2019 in two major university hospitals. All patients were evaluated for helicobacter pylori infection. Two gastric antral biopsy specimens were taken from each patient. One of those Biopsy specimens was evaluated for histopathology examination and the other one was immersed in a saline solution ready for genomic DNA extraction. Results: There were statistically significant differences between different genotypes of VDR rs7975232 polymorphism between H. pylori infected and non-infected groups (CC was higher in H. pylori negative and AC and AA were the most common in H. pylori positive group). There were statistical differences between different genotypes of VDR rs2228570 between H. pylori infected and non-infected groups (TT was higher in H. pylori negative and CT and CC were the most common in H. pylori positive group). Regarding VDR rs 7975232 gene polymorphisms; the (A) allele was significantly higher H. pylori infected, while (C) allele was significantly higher in uninfected patients. Regarding VDR rs 2228570 gene polymorphisms; the (C) allele was significantly higher H. pylori infected, while (T) allele was significantly higher in uninfected patients. Conclusion: There is a possible association between the FokI and Apal VDR polymorphism and H. pylori infection.

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To study the prevalence of Helicobacter pylori in patients with dyspepsia undergoing upper gastrointestinal endoscopy

International Journal of Surgery Science ◽

10.33545/surgery.2020.v4.i3d.492 ◽

2020 ◽

Vol 4 (3) ◽

pp. 208-210

Author(s):

Dr. Arjun A

Keyword(s):

Helicobacter Pylori ◽

Gastrointestinal Endoscopy ◽

Upper Gastrointestinal Endoscopy ◽

Upper Gastrointestinal

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Medication omissions in the first 48 hours after admission: failure in prescribed medicines reaching in-patients in paediatrics wards at the University Teaching Hospitals, Children’s Hospital in Lusaka, Zambia

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20214497 ◽

2021 ◽

Vol 10 (12) ◽

pp. 1324

Author(s):

Martin Kampamba ◽

Steven Mulolo ◽

Margaret Phiri ◽

Martha Chibale Chulu ◽

Webrod Mufwambi ◽

...

Keyword(s):

Medication Administration ◽

Median Number ◽

Hospital Length ◽

University Teaching ◽

Hospital Length Of Stay ◽

Teaching Hospitals ◽

Prescribed Medicines ◽

The University ◽

University Teaching Hospitals ◽

Omission Errors

Background: The first few days of in-patient care are possibly the most significant in a patient’s recovery and any omitted medications during this period may harm the patient or increase their hospital length of stay. Therefore, our study aimed at assessing the frequency of medication administration omission errors and their reasons for the omission in the paediatric wards after admission at University Teaching Children’s Hospital.Methods: This was a descriptive study in which 259 patient files and drug charts were reviewed. Admission prescription charts were studied in detail over a period of four weeks and all drugs prescribed but then not given in the first 48 hours were recorded as omitted medications, along with the reason given for their omission.Results: From the 259 drug charts, a total of 1598 doses of drugs were ordered within 48 hours of admission. However, from this, only a total of 1132 doses were administered with the remaining 466 doses omitted, which accounted for a frequency of 29.2%. When the frequency of medication omission errors was compared, parenteral drugs (70.8% vs. 25.3%, [p=0.0001]), afternoon shift (48.5% vs. 15.8%, [p=0.0001]), and anti-infective medications (69.1% vs. 39.4%, [p=0.0001]) were found to be the most frequently omitted medications. There were also considerably more medication omissions in patients prescribed with more medications (median number: 4, I QR [2, 6] vs. median number: 2, IQR [2, 4], [p=0. 0.001]). The most common reason for the omission was medication unavailability (89.3%), followed by work overload (71.4%), and the patient is off the ward (71.4%).Conclusions: This study revealed that medication omissions are a continuing problem and this may result in increased morbidity and mortality rates. There is a need to put in place specific strategies to reduce this problem.

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Prevalence of Helicobacter pylori infection & pattern of gastrointestinal involvement in patients undergoing upper gastrointestinal endoscopy in Sikkim

The Indian Journal of Medical Research ◽

10.4103/ijmr.ijmr_1482_16 ◽

2018 ◽

Vol 147 (5) ◽

pp. 517 ◽

Cited By ~ 1

Author(s):

Mona Dhakal ◽

OP Dhakal

Keyword(s):

Helicobacter Pylori ◽

Gastrointestinal Endoscopy ◽

Helicobacter Pylori Infection ◽

Upper Gastrointestinal Endoscopy ◽

Gastrointestinal Involvement ◽

Infection Pattern ◽

Upper Gastrointestinal

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1445Antibiotic susceptibility of Helicobacter pylori in Arctic Canadian Indigenous communities

International Journal of Epidemiology ◽

10.1093/ije/dyab168.392 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Lauren Lindsey ◽

Doug Quilty ◽

Taylor Cromarty ◽

Ali Assi ◽

Sander Veldhuyzen van Zanten ◽

...

Keyword(s):

Helicobacter Pylori ◽

Disease Burden ◽

Gastrointestinal Endoscopy ◽

Indigenous Communities ◽

Upper Gastrointestinal Endoscopy ◽

Antibiotic Resistant ◽

Resistance Patterns ◽

Gastric Biopsies ◽

Antibiotic Resistance Patterns ◽

Upper Gastrointestinal

Abstract Background Our community-driven projects address concerns of Canadian Arctic Indigenous communities about Helicobacter pylori (Hp) infection, responsible for elevated gastric cancer mortality in the region. A key concern is poor effectiveness of anti-Hp treatment. We aimed to describe antibiotic resistance patterns in Hp isolated from project participants. Methods Participants in 7 communities underwent upper gastrointestinal endoscopy with 2 gastric biopsies taken for tissue culture during 2008-2017. We tested Hp isolates for resistance to 7 antibiotics by Etest and assessed 4 outcomes: resistance to metronidazole, clarithromycin, 1+ antibiotics, and 2+ antibiotics. We tabulated proportion positive among isolates tested with 95% confidence intervals (CI) and used logistic regression to assess the relation of age and sex to resistance outcomes. Results Of 259 Hp isolates tested, resistance to metronidazole, clarithromycin, 1+ antibiotics, and 2+ antibiotics were (% [CI]): respectively, 35 [29-41], 19 [15-25], 44 [38-50], and 12 [8-17] overall; 38 [30-47], 24 [17-32], 49 [41-58], and 16 [11-23] in 146 isolates from women; and 30 [22-39], 13 [8-21], 36 [27-46], and 6 [3-12] in 113 isolates from men. Odds of resistance to clarithromycin, 1+ antibiotics, 2+ antibiotics, and, to a lesser degree metronidazole, were elevated in women relative to men after age adjustment and increased with age in women but not men. Conclusion In Arctic Indigenous communities in Canada, women were more likely than men to harbor antibiotic-resistant Hp, and their frequency of resistant Hp infection increased with age. Key messages Community-driven research answers questions posed by those who bear the disease burden.

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