scholarly journals Pressure ulcers and Charcot's definitions: report on two cases

2008 ◽  
Vol 126 (4) ◽  
pp. 223-224 ◽  
Author(s):  
Hélio Afonso Ghizoni Teive ◽  
Ricardo William Genaro Rodrigues de Campos ◽  
Renato Puppi Munhoz ◽  
Lineu César Werneck
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Pressure Ulcers ◽  
Case Reports ◽  
Vegetative State ◽  
Persistent Vegetative State ◽  
Connective Tissues ◽  
First Case ◽  
Neurological Patients ◽  
Developed Pressure ◽  
Lateral Sclerosis

CONTEXT AND OBJECTIVE: Pressure ulcers are lesions caused by inadequate blood flow and tissue malnourishment secondary to prolonged pressure on skin, soft connective tissues, muscle and/or bones. The authors report two distinct clinical situations of severely compromised neurological patients who shared several predisposing factors for pressure ulcers, but with opposite outcomes regarding the development of pressure ulcers. CASE REPORTS: The first case was a young patient in a persistent vegetative state who developed pressure ulcers that resulted in secondary sepsis and death. The second case was a patient with a diagnosis of amyotrophic lateral sclerosis who, in spite of being bedridden for several months with severe immobility, never developed pressure ulcers. These intriguing contrary clinical situations had already been defined by Charcot in the nineteenth century, with his creation of the expression "decubitus ominosus". He indicated that patients with amyotrophic lateral sclerosis usually did not develop this form of complication, as was illustrated by the cases presented here.

scholarly journals Frontotemporal dementia and amyotrophic lateral sclerosis: Revisiting one of the first case reports with neuropathological examination

2014 ◽  
Vol 8 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Ricardo Nitrini
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Frontotemporal Dementia ◽  
Motor Neurons ◽  
Case Reports ◽  
Rare Event ◽  
Motor Impairments ◽  
Late 20Th Century ◽  
First Case ◽  
Lateral Sclerosis ◽  
Neuropathological Examination

ABSTRACT The occurrence of dementia in amyotrophic lateral sclerosis (ALS) was only widely recognized in the late 20th century. Hitherto, it was believed that dementia was a rare event due to the fortuitous association with other diseases. In 1924, Kostantin Nikolaevich Tretiakoff and Moacyr de Freitas Amorim reported a case of dementia with features of frontotemporal dementia (FTD) that preceded the motor signs of ALS. Neuropathological examination confirmed ALS and found no signs of other dementia-causing diseases. The authors hypothesized that dementia was part of ALS and recommended the search for signs of involvement of motor neurons in cases of dementia with an ill-defined clinical picture, a practice currently accepted in the investigation of cases of FTD. This was one of the first descriptions of dementia preceding the motor impairments of ALS and was published in Portuguese and French in Memórias do Hospício de Juquery.

scholarly journals Teaching an Old Dog New Tricks: Serum Troponin T as a Biomarker in Amyotrophic Lateral Sclerosis

2021 ◽  
Author(s):  
Sergio Castro-Gomez ◽  
Barbara Radermacher ◽  
Pawel Tacik ◽  
Sandra R. Mirandola ◽  
Michael T. Heneka ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Troponin I ◽  
Troponin T ◽  
Case Reports ◽  
Neuromuscular Disorders ◽  
University Hospital ◽  
Biological Origin ◽  
Muscle Involvement ◽  
Als Patients ◽  
Lateral Sclerosis

AbstractAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive loss of upper and lower motor neurons. Diagnosis, management and therapeutic trials are hampered by a lack of informative biomarkers. Troponins (Tn) are components of skeletal and cardiac muscles. Acute elevation of cardiac isoforms of troponin I (cTnI) and T (cTnT) in serum indicates myocardial injury. Case reports suggested that serum levels of cTnT, but not cTnI are chronically elevated in ALS and other neuromuscular disorders.Using standard clinical laboratory methodologies we studied serum troponin levels in a multicentric cross-sectional cohort of 75 ALS patients and sixty controls (DESCRIBE-ALS cohort) and in a real-world cohort of 179 consecutive patients from our ALS clinic at the University Hospital Bonn.We found that serum cTnT, is elevated in >60% of ALS patients while cTnI is always normal. Serum cTnT levels increase over time and correlate with disease severity as measured with the revised ALS FRS score. There was no correlation with the phosphorylated neurofilament heavy chain (pNfH) levels in the cerebrospinal fluid. We propose that cTnT elevations in ALS are of non-cardiac origin and may serve as a proxy of lower motor neuron or skeletal muscle involvement. They potentially help to stratify patients according to lower motoneuron involvement. Further research will determine the biological origin of the cTnT elevation and its validity as a diagnostic and/or prognostic marker. Our finding also serves as a reminder to interpret cTnT with caution elevations in patients with neuromuscular diseases.

scholarly journals First Case of TARDBP-Related Amyotrophic Lateral Sclerosis in Korea

2020 ◽  
Vol 16 (4) ◽  
pp. 709
Author(s):  
Hee Jo Han ◽  
Hyung Jun Park ◽  
UnKyu Yun ◽  
Young-Chul Choi
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
First Case ◽  
Lateral Sclerosis

Three new case reports of Arteriovenous malformation-related Amyotrophic Lateral Sclerosis

2018 ◽  
Vol 393 ◽  
pp. 58-62 ◽  
Author(s):  
Maria Chondrogianni ◽  
Marianna Bregianni ◽  
Frantzeska Frantzeskaki ◽  
Evangelos Giamarellos-Bourboulis ◽  
Evangelos Anagnostou ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Arteriovenous Malformation ◽  
Case Reports ◽  
Lateral Sclerosis

scholarly journals Is Lesion of Exner’s Area Linked to Progressive Agraphia in Amyotrophic Lateral Sclerosis with Dementia? An Autopsy Case Report

2010 ◽  
Vol 23 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Kenji Ishihara ◽  
Hiroo Ichikawa ◽  
Yoshio Suzuki ◽  
Jun’ichi Shiota ◽  
Imaharu Nakano ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Brain Lesion ◽  
Intimate Relationship ◽  
Autopsy Case ◽  
First Case ◽  
Neuropsychological Symptoms ◽  
The Brain ◽  
Caudal Area ◽  
Left Middle ◽  
Lateral Sclerosis

Agraphia, as a neuropsychological symptom of ALS, especially ALS with dementia (ALS-D), has recently attracted more attention. However, the brain lesion responsible has not been identified. Here we present an autopsy case of ALS-D of a patient with obvious agraphia, without aphasia, that also presented cerebrospinal degeneration with TDP-43-pathology compatible with ALS-D. Of the pre-motor frontal lobe cortices, degeneration and immuno-histochemical pathology were most obvious in the caudal area of the left middle frontal gyrus, or Exner’s area. Assuring this area plays a pivotal role in the kanji and kana formation used in writing the Japanese language, this case of ALS-D showed both agraphia and Exner's area stressed pathological lesions. It may thus be the first case to indicate an intimate relationship between the neuropsychological symptoms and an associated lesion for ALS-D.

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